{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:00:34Z","timestamp":1793106034776,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK069350"],"award-info":[{"award-number":["DK069350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK095944"],"award-info":[{"award-number":["DK095944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>In hypoparathyroidism, areal bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) is above average, and skeletal indices by bone biopsy are abnormal. We used high-resolution peripheral quantitative computed tomography (HRpQCT) and finite element analyses (FEA) to further investigate skeletal microstructure and estimated bone strength. We studied 60 hypoparathyroid subjects on conventional therapy using DXA, HRpQCT, and FEA of the distal radius and tibia compared with normative controls from the Canadian Multicentre Osteoporosis Study. In hypoparathyroid women and men, areal BMD was above average at the lumbar spine and hip sites by DXA; radial BMD was also above average in hypoparathyroid women. Using HRpQCT, cortical volumetric BMD was increased in the hypoparathyroid cohort compared with controls at both the radius and tibia. Cortical porosity was reduced at both sites in pre- and postmenopausal women and at the tibia in young men with a downward trend at the radius in men. At the tibia, trabecular number was increased in premenopausal women and men and trabecular thickness was lower in women. Ultimate stress and failure load at both sites for the hypoparathyroid subjects were similar to controls. Using a linear regression model, at both radius and tibia, each increment in age decreased ultimate stress and failure load, whereas each increment in duration of hypoparathyroidism increased these same indices. These results provide additional evidence for the critical role of parathyroid hormone in regulating skeletal microstructure. Longer disease duration may mitigate the adverse effects of age on estimated bone strength in hypoparathyroidism. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2609","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T16:29:51Z","timestamp":1438446591000},"page":"308-316","source":"Crossref","is-referenced-by-count":76,"title":["Noninvasive Assessment of Skeletal Microstructure and Estimated Bone Strength in Hypoparathyroidism"],"prefix":"10.1093","volume":"31","author":[{"given":"Natalie E","family":"Cusano","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle K","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishaela R","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Boutroy","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, H\u00f4pital Edouard HerriotUniversit\u00e9 de LyonLyonFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X Edward","family":"Guo","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory, Department of Biomedical EngineeringColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"issue":"11","key":"2024021014190976000_jbmr2609-bib-0001","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1002\/jbmr.452","article-title":"PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism","volume":"26","author":"Rubin","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024021014190976000_jbmr2609-bib-0002","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1359\/jbmr.080803","article-title":"Dynamic and structural properties of the skeleton in hypoparathyroidism","volume":"23","author":"Rubin","year":"2008","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024021014190976000_jbmr2609-bib-0003","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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