{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:52:47Z","timestamp":1790319167585,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":3018,"URL":"https:\/\/creativecommons.org\/licenses\/cc-by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Hyperandrogenism, obesity, and hyperinsulinemia may protect against osteoporosis, whereas amenorrhea, increased cortisol, and low growth hormone may be associated with higher fracture risk in polycystic ovary syndrome (PCOS). The objective of this study was to investigate fracture risk in PCOS. In the PCOS Denmark study, women with PCOS and\/or hirsutism were identified in the Danish National Patient Register (1995\u20132012). Each patient was assigned three age-matched controls on the index date of PCOS diagnosis. Individuals with a previous endocrine diagnosis were excluded. Within PCOS Denmark, we embedded a well-characterized subcohort of patients, PCOS OUH, diagnosed with PCOS at Odense University Hospital (n\u2009=\u20091217). We identified incident fractures by International Classification of Diseases, 10th Revision (ICD-10) codes and used conditional Cox regression analyses to compare fracture risk. In the PCOS Denmark study, there were 19,199 women with PCOS and 57,483 controls were included, mean age 30.6 years (range, 12\u201360 years). Fracture rates were decreased in PCOS Denmark (10.3\/1000 patient years) versus controls (13.6\/1000 patient years). The adjusted ORs were 0.76 (95% CI, 0.71 to 0.80) for all fractures, 0.82 (95% CI, 0.74 to 0.92) for major osteoporotic fractures, and 0.57 (95% CI, 0.47 to 0.70) for fractures of head and face. The risk reduction was more pronounced below the age of 30 years at diagnosis. Women with PCOS had significant more hospital contacts due to strains and sprains. In the PCOS OUH subcohort, the risk reduction of fractures did not differ between PCOS women with elevated versus normal testosterone levels and the risk reduction was nominally smaller in overweight versus normal weight PCOS women. Women with PCOS had reduced risk of fractures, in particular of the appendicular skeleton. The risk reduction was greater in women with younger age at diagnosis suggesting that the skeletal effects of PCOS may be greater in women who have not yet reached peak bone mass. Reduced participation in sports activities was probably not the reason for the reduced risk of fractures. \u00a9 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2737","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T11:05:56Z","timestamp":1446807956000},"page":"709-717","source":"Crossref","is-referenced-by-count":39,"title":["Fracture Risk Is Decreased in Women With Polycystic Ovary Syndrome: A Register-Based and Population-Based Cohort Study"],"prefix":"10.1093","volume":"31","author":[{"given":"Katrine Hass","family":"Rubin","sequence":"first","affiliation":[{"name":"Odense Patient Data Explorative Network (OPEN)Department of Clinical ResearchUniversity of Southern Denmark and Odense University HospitalOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Department of EndocrinologyOdense University HospitalOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Nybo","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and PharmacologyOdense University HospitalOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of EndocrinologyOdense University HospitalOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Department of MedicineHolb\u00e6k HospitalHolb\u00e6kDenmark"},{"name":"Odense Patient Data Explorative Network (OPEN)Department of Clinical ResearchUniversity of Southern Denmark and Odense University HospitalOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"issue":"5)","key":"2024021014175033000_jbmr2737-bib-0001","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1210\/jc.2007-2249","article-title":"Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial","volume":"93","author":"Glintborg","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"1)","key":"2024021014175033000_jbmr2737-bib-0002","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF01880413","article-title":"The contribution of bone loss to postmenopausal osteoporosis","volume":"1","author":"Hui","year":"1990","journal-title":"Osteoporos Int"},{"issue":"3)","key":"2024021014175033000_jbmr2737-bib-0003","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00198-005-2039-5","article-title":"Hanson M. 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