{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:03:34Z","timestamp":1791047014176,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T00:00:00Z","timestamp":1448064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR054620"],"award-info":[{"award-number":["AR054620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The biomechanical mechanisms leading to vertebral fractures are not well understood. Clinical and laboratory evidence suggests that the vertebral endplate plays a key role in failure of the vertebra as a whole, but how this role differs for different types of vertebral loading is not known. Mechanical testing of human thoracic spine segments, in conjunction with time-lapsed micro\u2013computed tomography, enabled quantitative assessment of deformations occurring throughout the entire vertebral body under axial compression combined with anterior flexion (\u201ccombined loading\u201d) and under axial compression only (\u201ccompression loading\u201d). The resulting deformation maps indicated that endplate deflection was a principal feature of vertebral failure for both loading modes. Specifically, the onset of endplate deflection was temporally coincident with a pronounced drop in the vertebra's ability to support loads. The location of endplate deflection, and also vertebral strength, were associated with the porosity of the endplate and the microstructure of the underlying trabecular bone. However, the location of endplate deflection and the involvement of the cortex differed between the two types of loading. Under the combined loading, deflection initiated, and remained the largest, at the anterior central endplate or the anterior ring apophysis, depending in part on health of the adjacent intervertebral disc. This deflection was accompanied by outward bulging of the anterior cortex. In contrast, the location of endplate deflection was more varied in compression loading. For both loading types, the earliest progression to a mild fracture according to a quantitative morphometric criterion occurred only after much of the failure process had occurred. The outcomes of this work indicate that for two physiological loading modes, the vertebral endplate and underlying trabecular bone are critically involved in vertebral fracture. These outcomes provide a strong biomechanical rationale for clinical methods, such as algorithm-based qualitative (ABQ) assessment, that diagnose vertebral fracture on the basis of endplate depression. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2749","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T23:17:00Z","timestamp":1448147820000},"page":"777-788","source":"Crossref","is-referenced-by-count":46,"title":["Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion"],"prefix":"10.1093","volume":"31","author":[{"given":"Timothy M","family":"Jackman","sequence":"first","affiliation":[{"name":"Department of Biomedical EngineeringBoston UniversityBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira I","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Mechanical EngineeringBoston UniversityBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Curtiss","sequence":"additional","affiliation":[{"name":"Department of Biomedical EngineeringBoston UniversityBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Fein","sequence":"additional","affiliation":[{"name":"Department of Mechanical EngineeringBoston UniversityBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Camp","sequence":"additional","affiliation":[{"name":"Department of Mechanical EngineeringBoston UniversityBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"De Barros","sequence":"additional","affiliation":[{"name":"Department of Biomedical EngineeringBoston 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