{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:32:57Z","timestamp":1767706377614},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Weijerhorst Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Fracture healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable distal radius fracture within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in bone mineral density (BMD), microarchitecture, and bone stiffness after a distal radius fracture during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline BMD, microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal women (mean age 64\u2009\u00b1\u20098 years) with a conservatively treated distal radius fracture was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. BMD, microarchitecture, and stiffness parameters were determined and the fracture side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year bone stiffness with baseline BMD, microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p &amp;lt; 0.05), whereas BMD was similar. Two-year torsional and bending stiffness correlated significantly with baseline BMD and cortical perimeter (|rho| \u2265 0.63, p &amp;lt; 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that fracture healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in BMD, microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower BMD and higher cortical perimeter at baseline. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2766","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T14:54:09Z","timestamp":1450364049000},"page":"1114-1122","source":"Crossref","is-referenced-by-count":32,"title":["Fracture Repair in the Distal Radius in Postmenopausal Women: A Follow-Up 2 Years Postfracture Using HRpQCT"],"prefix":"10.1093","volume":"31","author":[{"given":"Joost JA","family":"de Jong","sequence":"first","affiliation":[{"name":"Department of RheumatologyMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans L","family":"Heyer","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineVieCuri Medical CenterVenloThe Netherlands"},{"name":"Department of SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobus JC","family":"Arts","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary CareMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"Department of Orthopedic SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Poeze","sequence":"additional","affiliation":[{"name":"Department of SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s P","family":"Keszei","sequence":"additional","affiliation":[{"name":"Department of Medical InformaticsUniklinik RWTH Aachen UniversityAachenGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C","family":"Willems","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary CareMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"Department of Orthopedic SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"van Rietbergen","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical EngineeringEindhoven University of TechnologyEindhovenThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet P","family":"Geusens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium"},{"name":"CAPHRI School for Public Health and Primary CareMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"Department of RheumatologyMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joop PW","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium"},{"name":"Department of Internal MedicineVieCuri Medical CenterVenloThe Netherlands"},{"name":"Department of RheumatologyMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Medical CenterMaastrichtThe 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