{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:22:25Z","timestamp":1761513745707},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK069350"],"award-info":[{"award-number":["DK069350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006621","name":"Newton Public Schools, City of Newton","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The microstructural skeletal phenotype of hypoparathyroidism (HypoPT), a disorder of inadequate parathyroid hormone secretion, is altered trabecular microarchitecture with increased trabecular bone volume and thickness. Using 2-D histomorphometric analysis, we previously found that 2 years of PTH(1-84) in HypoPT is associated with reduced trabecular thickness (Tb.Th) and an increase in trabecular number (Tb.N). We have now utilized direct 3-D microstructural analysis to determine the extent to which these changes may be related to bone strength. Iliac crest bone biopsies from HypoPT subjects (n\u2009=\u200958) were analyzed by microcomputed tomography (\u03bcCT) and by microfinite element (\u03bcFE) analysis. Biopsies were performed at baseline and at 1 or 2 years of recombinant human PTH(1-84) [rhPTH(1-84)]. In a subset of subjects (n = 13) at 3 months, we demonstrated a reduction in trabecular separation (Tb.Sp, 0.64\u2009\u00b1\u20090.1 to 0.56\u2009\u00b1\u20090.1\u2009mm; p\u2009=\u20090.005) and in the variance of trabecular separation (Tb.SD, 0.19\u2009\u00b1\u20090.1 to 0.17\u2009\u00b1\u20090.1\u2009mm; p\u2009=\u20090.01), along with an increase in bone volume\/total volume (BV\/TV, 26.76\u2009\u00b1\u200910.1 to 32.83\u2009\u00b1\u200913.5%; p\u2009=\u20090.02), bone surface\/total volume (BS\/TV, 3.85\u2009\u00b1\u20090.7 to 4.49\u2009\u00b1\u20091.0 mm2\/mm3; p\u2009=\u20090.005), Tb.N (1.84\u2009\u00b1\u20090.5 versus 2.36\u2009\u00b1\u20091.3 mm\u22121; p\u2009=\u20090.02) and Young's modulus (649.38\u2009\u00b1\u2009460.7 to 1044.81\u2009\u00b1\u20091090.5\u2009N\/mm2; p\u2009=\u20090.049). After 1 year of rhPTH(1-84), Force increased (144.08\u2009\u00b1\u2009102.4 to 241.13\u2009\u00b1\u2009189.1\u2009N; p\u2009=\u20090.04) and Young's modulus tended to increase (662.15\u2009\u00b1\u2009478.2 to 1050.80\u2009\u00b1\u2009824.1\u2009N\/m2; p\u2009=\u20090.06). The 1-year change in cancellous mineralizing surface (MS\/BS) predicted 1-year changes in \u03bcCT variables. The biopsies obtained after 2 years of rhPTH(1-84) showed no change from baseline. These data suggest that administration of rhPTH(1-84) in HypoPT is associated with transient changes in key parameters associated with bone strength. The results indicate that rhPTH(1-84) improves skeletal quality in HypoPT early in treatment. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2777","type":"journal-article","created":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T14:54:19Z","timestamp":1451746459000},"page":"1082-1088","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Parathyroid Hormone Administration on Bone Strength in Hypoparathyroidism"],"prefix":"10.1093","volume":"31","author":[{"given":"Mishaela R","family":"Rubin","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew York, NYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Zwahlen","sequence":"additional","affiliation":[{"name":"Institute for BiomechanicsETH ZurichZurichSwitzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Dempster","sequence":"additional","affiliation":[{"name":"Regional Bone CenterHelen Hayes HospitalWest HaverstrawNYUSA"},{"name":"Department of Pathology, College of Physicians and SurgeonsColumbia UniversityNew York, NYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Regional Bone CenterHelen Hayes HospitalWest HaverstrawNYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie E","family":"Cusano","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew York, NYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew York, NYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for BiomechanicsETH ZurichZurichSwitzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew York, NYUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2024021014182436000_jbmr2777-bib-0001","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1002\/jbmr.452","article-title":"PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism","volume":"26","author":"Rubin","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2024021014182436000_jbmr2777-bib-0002","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1359\/jbmr.080803","article-title":"Dynamic and structural properties of the skeleton in hypoparathyroidism","volume":"23","author":"Rubin","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2024021014182436000_jbmr2777-bib-0003","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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