{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:05:12Z","timestamp":1793390712241,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007919","name":"University of Massachusetts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Increased fracture risk has been associated with weight loss in postmenopausal women, but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of \u226510 lb (4.5\u2009kg) in postmenopausal women on fracture risk at multiple sites up to 5 years after weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed the relationships between self-reported unintentional weight loss of \u226510 lb at baseline, year 2, or year 3 and incident clinical fracture in the years after weight loss. Complete data were available in 40,179 women (mean age\u2009\u00b1\u2009SD 68\u2009\u00b1\u20098.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years after weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is found as early as 1 year after weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2810","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T09:56:06Z","timestamp":1455098166000},"page":"1466-1472","source":"Crossref","is-referenced-by-count":37,"title":["Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women"],"prefix":"10.1093","volume":"31","author":[{"given":"Juliet E","family":"Compston","sequence":"first","affiliation":[{"name":"Cambridge Biomedical CampusCambridgeUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Wyman","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Adachi","sequence":"additional","affiliation":[{"name":"St Joseph's HealthcareMcMaster UniversityHamiltonCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland D","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, INSERM U1033Universit\u00e9 de LyonH\u00f4pital E HerriotLyonFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology UnitUniversity of SouthamptonSouthamptonUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"D\u00edez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"RETICEFInstituto Carlos IIIMadridSpain"},{"name":"Hospital del Mar-IMIM-Autonomous University of BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H","family":"Gehlbach","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"Greenspan","sequence":"additional","affiliation":[{"name":"University of PittsburghPittsburghPAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick H","family":"Hooven","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Z","family":"LaCroix","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research CenterSeattleWAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn","family":"March","sequence":"additional","affiliation":[{"name":"University of Sydney Institute of Bone and Joint Research and Department of RheumatologyRoyal North Shore HospitalSydneyAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Coen","family":"Netelenbos","sequence":"additional","affiliation":[{"name":"Department of EndocrinologyVU University Medical CenterAmsterdamNetherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeri W","family":"Nieves","sequence":"additional","affiliation":[{"name":"Helen Hayes Hospital and Columbia UniversityWest HaverstrawNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pfeilschifter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IIIAlfried Krupp KrankenhausEssenGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Rossini","sequence":"additional","affiliation":[{"name":"Rheumatology SectionDepartment of MedicineUniversity of VeronaVeronaItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roux","sequence":"additional","affiliation":[{"name":"Paris Descartes UniversityCochin HospitalParisFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G","family":"Saag","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and RheumatologyUniversity of Alabama at BirminghamBirminghamALUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel S","family":"Siris","sequence":"additional","affiliation":[{"name":"Columbia University Medical CenterNew 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