{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:21:35Z","timestamp":1790893295891,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Hypoparathyroidism is a disease of chronic hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone (PTH). PTH and analogs of the hormone are of interest as potential therapies. Accordingly, we examined the pharmacological properties of a long-acting PTH analog, [Ala1,3,12,18,22, Gln10,Arg11,Trp14,Lys26]-PTH(1-14)\/PTHrP(15-36) (LA\u2013PTH) in thyroparathyroidectomized (TPTX) rats, a model of HP, as well as in normal monkeys. In TPTX rats, a single intravenous administration of LA-PTH at a dose of 0.9 nmol\/kg increased serum calcium (sCa) and decreased serum phosphate (sPi) to near-normal levels for longer than 48 hours, whereas PTH(1-34) and PTH(1-84), each injected at a dose 80-fold higher than that used for LA-PTH, increased sCa and decreased sPi only modestly and transiently (&amp;lt;6 hours). LA-PTH also exhibited enhanced and prolonged efficacy versus PTH(1-34) and PTH(1-84) for elevating sCa when administered subcutaneously (s.c.) into monkeys. Daily s.c. administration of LA-PTH (1.8 nmol\/kg) into TPTX rats for 28 days elevated sCa to near normal levels without causing hypercalciuria or increasing bone resorption markers, a desirable goal in the treatment of hypoparathyroidism. The results are supportive of further study of long-acting PTH analogs as potential therapies for patients with hypoparathyroidism. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2811","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T11:31:34Z","timestamp":1455190294000},"page":"1405-1412","source":"Crossref","is-referenced-by-count":89,"title":["Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys"],"prefix":"10.1093","volume":"31","author":[{"given":"Masaru","family":"Shimizu","sequence":"first","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Joyashiki","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Noda","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"},{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Nagayasu","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Adachi","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Tamura","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John T","family":"Potts","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Gardella","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Research DivisionChugai Pharmaceutical Co., Ltd.ShizuokaJapan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"issue":"10","key":"2024021014180383100_jbmr2811-bib-0001","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024021014180383100_jbmr2811-bib-0002","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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