{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:03:30Z","timestamp":1770815010456,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DE 7327\u201012"],"award-info":[{"award-number":["T32 DE 7327\u201012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE\u2010019917"],"award-info":[{"award-number":["DE\u2010019917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE\u2010018499"],"award-info":[{"award-number":["DE\u2010018499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>By binding to its chemokine receptor CXCR4 on osteoclast precursor cells (OCPs), it is well known that stromal cell-derived factor-1 (SDF-1) promotes the chemotactic recruitment of circulating OCPs to the homeostatic bone remodeling site. However, the engagement of circulating OCPs in pathogenic bone resorption remains to be elucidated. The present study investigated a possible chemoattractant role of macrophage migration inhibitory factor (MIF), another ligand for C-X-C chemokine receptor type 4 (CXCR4), in the recruitment of circulating OCPs to the bone lytic lesion. To accomplish this, we used Csf1r-eGFP-knock-in (KI) mice to establish an animal model of polymethylmethacrylate (PMMA) particle-induced calvarial osteolysis. In the circulating Csf1r-eGFP+ cells of healthy Csf1r-eGFP-KI mice, Csf1r+\/CD11b+ cells showed a greater degree of RANKL-induced osteoclastogenesis compared to a subset of Csf1r+\/RANK+ cells in vitro. Therefore, Csf1r-eGFP+\/CD11b+ cells were targeted as functionally relevant OCPs in the present study. Although expression of the two cognate receptors for MIF, CXCR2 and CXCR4, was elevated on Csf1r+\/CD11b+ cells, transmigration of OCPs toward recombinant MIF in vitro was facilitated by ligation with CXCR4, but not CXCR2. Meanwhile, the level of PMMA-induced bone resorption in calvaria was markedly greater in wild-type (WT) mice compared to that detected in MIF-knockout (KO) mice. Interestingly, in contrast to the elevated MIF, diminished SDF-1 was detected in a particle-induced bone lytic lesion of WT mice in conjunction with an increased number of infiltrating CXCR4+ OCPs. However, such diminished SDF-1 was not found in the PMMA-injected calvaria of MIF-KO mice. Furthermore, stimulation of osteoblasts with MIF in vitro suppressed their production of SDF-1, suggesting that MIF can downmodulate SDF-1 production in bone tissue. Systemically administered anti-MIF neutralizing monoclonal antibody (mAb) inhibited the homing of CXCR4+ OCPs, as well as bone resorption, in the PMMA-injected calvaria, while increasing locally produced SDF-1. Collectively, these data suggest that locally produced MIF in the inflammatory bone lytic site is engaged in the chemoattraction of circulating CXCR4+ OCPs. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2854","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T21:46:55Z","timestamp":1460756815000},"page":"1688-1700","source":"Crossref","is-referenced-by-count":39,"title":["Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions"],"prefix":"10.1093","volume":"31","author":[{"given":"Alexandru","family":"Movila","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of OrthodonticsTokyo Dental CollegeTokyoJapan"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Albassam","sequence":"additional","affiliation":[{"name":"Faculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia"},{"name":"School of Dental MedicineHarvard UniversityBostonMAUSA"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wichaya","family":"Wisitrasameewong","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of DentistryChulalongkorn UniversityBangkokThailand"},{"name":"School of Dental MedicineHarvard UniversityBostonMAUSA"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Howait","sequence":"additional","affiliation":[{"name":"Faculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuguno","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Research and Development HeadquartersLION CorporationKanagawaJapan"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Ruiz-Torruella","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Bahammam","sequence":"additional","affiliation":[{"name":"Faculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Graduate School of DentistryTohoku UniversitySendaiJapan"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Kawai","sequence":"additional","affiliation":[{"name":"School of Dental MedicineHarvard UniversityBostonMAUSA"},{"name":"Department of Immunology and Infectious DiseasesThe Forsyth InstituteCambridgeMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"issue":"20","key":"2024021014172887900_jbmr2854-bib-0001","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1016\/j.biomaterials.2004.01.003","article-title":"Regulation of osteoclast activity in peri-implant tissues","volume":"25","author":"Haynes","year":"2004","journal-title":"Biomaterials"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0002","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1753425912451779","article-title":"Particle disease: biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty","volume":"19","author":"Gallo","year":"2013","journal-title":"Innate Immun"},{"issue":"34","key":"2024021014172887900_jbmr2854-bib-0003","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0004","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.1201345","article-title":"Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques","volume":"190","author":"Kotani","year":"2013","journal-title":"J Immunol"},{"issue":"4","key":"2024021014172887900_jbmr2854-bib-0005","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/jor.21548","article-title":"Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles","volume":"30","author":"Gibon","year":"2012","journal-title":"J Orthop Res"},{"issue":"4","key":"2024021014172887900_jbmr2854-bib-0006","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/jbm.a.32803","article-title":"Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells","volume":"94","author":"Huang","year":"2010","journal-title":"J Biomed Mater Res A"},{"issue":"7237","key":"2024021014172887900_jbmr2854-bib-0007","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature07713","article-title":"Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis","volume":"458","author":"Ishii","year":"2009","journal-title":"Nature"},{"issue":"13","key":"2024021014172887900_jbmr2854-bib-0008","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1084\/jem.20101474","article-title":"Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo","volume":"207","author":"Ishii","year":"2010","journal-title":"J Exp Med"},{"issue":"8","key":"2024021014172887900_jbmr2854-bib-0009","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1359\/jbmr.2003.18.8.1404","article-title":"Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration","volume":"18","author":"Yu","year":"2003","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2024021014172887900_jbmr2854-bib-0010","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.4049\/jimmunol.0803627","article-title":"Role of CX3CL1\/fractalkine in osteoclast differentiation and bone resorption","volume":"183","author":"Koizumi","year":"2009","journal-title":"J Immunol"},{"issue":"9","key":"2024021014172887900_jbmr2854-bib-0011","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/art.20470","article-title":"Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice","volume":"50","author":"Gregory","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0012","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.4049\/jimmunol.0904104","article-title":"Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules","volume":"185","author":"Cheng","year":"2010","journal-title":"J Immunol"},{"issue":"6","key":"2024021014172887900_jbmr2854-bib-0013","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-05-2011","article-title":"Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB","volume":"107","author":"Amin","year":"2006","journal-title":"Blood"},{"issue":"5","key":"2024021014172887900_jbmr2854-bib-0014","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat Med"},{"issue":"9","key":"2024021014172887900_jbmr2854-bib-0015","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00296-013-2713-4","article-title":"Macrophage-derived, macrophage migration inhibitory factor (MIF) is necessary to induce disease in the K\/BxN serum-induced model of arthritis","volume":"33","author":"Singh","year":"2013","journal-title":"Rheumatol Int"},{"issue":"10","key":"2024021014172887900_jbmr2854-bib-0016","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00296-013-2877-y","article-title":"MIF, a potential therapeutic target for rheumatoid arthritis","volume":"34","author":"Chen","year":"2014","journal-title":"Rheumatol Int"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0017","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.micinf.2011.09.005","article-title":"MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice","volume":"14","author":"Madeira","year":"2012","journal-title":"Microbes Infect"},{"issue":"5","key":"2024021014172887900_jbmr2854-bib-0018","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cyto.2004.02.007","article-title":"Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody\/lipopolysaccharide (LPS)-induced arthritis in mice due to deletion of macrophage migration inhibitory factor (MIF)","volume":"26","author":"Ichiyama","year":"2004","journal-title":"Cytokine"},{"issue":"17","key":"2024021014172887900_jbmr2854-bib-0019","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.febslet.2009.07.058","article-title":"A functional heteromeric MIF receptor formed by CD74 and CXCR4","volume":"583","author":"Schwartz","year":"2009","journal-title":"FEBS Lett"},{"issue":"8","key":"2024021014172887900_jbmr2854-bib-0020","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.1003713","article-title":"Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase","volume":"186","author":"Fan","year":"2011","journal-title":"J Immunol"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0021","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cyto.2014.11.015","article-title":"Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis","volume":"72","author":"Gu","year":"2015","journal-title":"Cytokine"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0022","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jlb.57.1.180","article-title":"Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells","volume":"57","author":"Morohashi","year":"1995","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2024021014172887900_jbmr2854-bib-0023","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jlb.50.3.279","article-title":"[Ca2+]i changes and respiratory burst in human neutrophils and monocytes induced by NAP-1\/interleukin-8, NAP-2, and gro\/MGSA","volume":"50","author":"Walz","year":"1991","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2024021014172887900_jbmr2854-bib-0024","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/jbm.a.35330","article-title":"Metallic wear debris may regulate CXCR4 expression in vitro and in vivo","volume":"103","author":"Drynda","year":"2015","journal-title":"J Biomed Mater Res A"},{"key":"2024021014172887900_jbmr2854-bib-0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-61779-415-5_2","article-title":"Osteoblast isolation from murine calvaria and long bones","volume":"816","author":"Bakker","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"11","key":"2024021014172887900_jbmr2854-bib-0026","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.1302209","article-title":"MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling","volume":"192","author":"Klasen","year":"2014","journal-title":"J Immunol"},{"issue":"8","key":"2024021014172887900_jbmr2854-bib-0027","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20041385","article-title":"Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist","volume":"201","author":"Broxmeyer","year":"2005","journal-title":"J Exp Med"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0028","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/CDLI.5.1.11-17.1998","article-title":"A novel approach for detecting an immunodominant antigen of Porphyromonas gingivalis in diagnosis of adult periodontitis","volume":"5","author":"Kawai","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0029","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/IAI.67.2.942-945.1999","article-title":"Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein","volume":"67","author":"Komatsuzawa","year":"1999","journal-title":"Infect Immun"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0030","first-page":"235","article-title":"Migration inhibitory factor expression in experimentally induced endotoxemia","volume":"150","author":"Bacher","year":"1997","journal-title":"Am J Pathol"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0031","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/art.11419","article-title":"Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice","volume":"50","author":"Li","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"21\u201322","key":"2024021014172887900_jbmr2854-bib-0032","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.febslet.2008.08.023","article-title":"The role of Mac-1 (CD11b\/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand","volume":"582","author":"Hayashi","year":"2008","journal-title":"FEBS Lett"},{"issue":"12","key":"2024021014172887900_jbmr2854-bib-0033","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/jbmr.490","article-title":"Lineage-committed osteoclast precursors circulate in blood and settle down into bone","volume":"26","author":"Muto","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0034","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11420-006-9003-6","article-title":"The central role of wear debris in periprosthetic osteolysis","volume":"2","author":"Purdue","year":"2006","journal-title":"HSS J"},{"issue":"7","key":"2024021014172887900_jbmr2854-bib-0035","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/art.1780290704","article-title":"Formation of a synovial-like membrane at the bone-cement interface. Its role in bone resorption and implant loosening after total hip replacement","volume":"29","author":"Goldring","year":"1986","journal-title":"Arthritis Rheum"},{"issue":"4","key":"2024021014172887900_jbmr2854-bib-0036","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bone.2005.10.003","article-title":"Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing","volume":"38","author":"Jung","year":"2006","journal-title":"Bone"},{"issue":"4","key":"2024021014172887900_jbmr2854-bib-0037","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/jbmr.1787","article-title":"Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass","volume":"28","author":"Mun","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024021014172887900_jbmr2854-bib-0038","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bone.2009.06.028","article-title":"Macrophage migration inhibitory factor inhibits osteoclastogenesis","volume":"45","author":"Jacquin","year":"2009","journal-title":"Bone"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0039","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2249.2001.01423.x","article-title":"Role of macrophage migration inhibitory factor (MIF) in murine antigen-induced arthritis: interaction with glucocorticoids","volume":"123","author":"Santos","year":"2001","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0040","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1365-2249.2008.03639.x","article-title":"Reduced arthritis in MIF deficient mice is associated with reduced T cell activation: down-regulation of ERK MAP kinase phosphorylation","volume":"152","author":"Santos","year":"2008","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"2024021014172887900_jbmr2854-bib-0041","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/art.11165","article-title":"Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis","volume":"48","author":"Leech","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2024021014172887900_jbmr2854-bib-0042","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.170.3.1274","article-title":"In vivo blockade of macrophage migration inhibitory factor ameliorates acute experimental autoimmune encephalomyelitis by impairing the homing of encephalitogenic T cells to the central nervous system","volume":"170","author":"Denkinger","year":"2003","journal-title":"J Immunol"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0043","first-page":"117","article-title":"The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer","volume":"1825","author":"Verbeke","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2024021014172887900_jbmr2854-bib-0044","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.orthres.2004.06.018","article-title":"Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone","volume":"23","author":"Liao","year":"2005","journal-title":"J Orthop Res"},{"issue":"5","key":"2024021014172887900_jbmr2854-bib-0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bone.2005.01.021","article-title":"Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts","volume":"36","author":"Wright","year":"2005","journal-title":"Bone"},{"issue":"6","key":"2024021014172887900_jbmr2854-bib-0046","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/jre.12068","article-title":"Fundamental study of osteoclast chemotaxis toward chemoattractants expressed in periodontitis","volume":"48","author":"Niwa","year":"2013","journal-title":"J Periodontal Res"},{"issue":"8","key":"2024021014172887900_jbmr2854-bib-0047","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5483\/BMBRep.2014.47.8.159","article-title":"AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem\/progenitor cells","volume":"47","author":"Im","year":"2014","journal-title":"BMB Rep"},{"issue":"3","key":"2024021014172887900_jbmr2854-bib-0048","first-page":"529","article-title":"Identification of macrophage migration inhibitory factor in synovial membranes of loosened total joint replacement","volume":"39","author":"Suzuki","year":"1996","journal-title":"Biochem Mol Biol Int"},{"issue":"10","key":"2024021014172887900_jbmr2854-bib-0049","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0753-3322(94)90005-1","article-title":"Cytokines and macrophages","volume":"48","author":"Cavaillon","year":"1994","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2024021014172887900_jbmr2854-bib-0050","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.179.6.1895","article-title":"The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor","volume":"179","author":"Calandra","year":"1994","journal-title":"J Exp Med"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0051","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/ar2391","article-title":"TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood","volume":"10","author":"Zhang","year":"2008","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"2024021014172887900_jbmr2854-bib-0052","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1182\/blood-2002-10-3190","article-title":"Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion","volume":"102","author":"Wright","year":"2003","journal-title":"Blood"},{"issue":"9\u201310","key":"2024021014172887900_jbmr2854-bib-0053","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2119\/molmed.2009.00128","article-title":"ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma","volume":"16","author":"Chen","year":"2010","journal-title":"Mol Med"},{"issue":"8","key":"2024021014172887900_jbmr2854-bib-0054","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1093\/ndt\/gfh323","article-title":"Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy","volume":"19","author":"Leung","year":"2004","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"2024021014172887900_jbmr2854-bib-0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.20111739","article-title":"HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4","volume":"209","author":"Schiraldi","year":"2012","journal-title":"J Exp Med"},{"issue":"1\u20132","key":"2024021014172887900_jbmr2854-bib-0056","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbagrm.2009.11.014","article-title":"High-mobility group box 1 and cancer","volume":"1799","author":"Tang","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"2024021014172887900_jbmr2854-bib-0057","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/joim.12276","article-title":"High-mobility group box-1 in sterile inflammation","volume":"276","author":"Tsung","year":"2014","journal-title":"J Intern Med"},{"issue":"7","key":"2024021014172887900_jbmr2854-bib-0058","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1359\/jbmr.080234","article-title":"HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE","volume":"23","author":"Zhou","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"28","key":"2024021014172887900_jbmr2854-bib-0059","doi-asserted-by":"crossref","first-page":"24976","DOI":"10.1074\/jbc.M203220200","article-title":"The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents","volume":"277","author":"Lubetsky","year":"2002","journal-title":"J Biol Chem"},{"issue":"7","key":"2024021014172887900_jbmr2854-bib-0060","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1158\/1535-7163.MCT-12-0988","article-title":"Human anti-macrophage migration inhibitory factor antibodies inhibit growth of human prostate cancer cells in vitro and in vivo","volume":"12","author":"Hussain","year":"2013","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"2024021014172887900_jbmr2854-bib-0061","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4161\/mabs.1.2.7736","volume":"1","author":"Scolnik","year":"2009","journal-title":"mAbs: a business perspective. MAbs"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2854","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.2854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.2854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/31\/9\/1688\/56648270\/jbmr2854.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/31\/9\/1688\/56648270\/jbmr2854.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:56:15Z","timestamp":1710341775000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/31\/9\/1688-1700\/7604995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":61,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,4,15]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2854","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9,1]]},"published":{"date-parts":[[2016,4,15]]}}}