{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:03:50Z","timestamp":1781532230247,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Susana Carballo for editing the English language of the manuscript"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>We have recently identified a significant deterioration of bone microarchitecture in premenopausal women with newly diagnosed celiac disease (CD) using high-resolution peripheral quantitative computed tomography (HRpQCT). The aim of this work was to assess changes in bone microarchitecture after 1 year on a gluten-free diet (GFD) in a cohort of premenopausal women. We prospectively enrolled 31 consecutive females at diagnosis of CD; 26 of them were reassessed 1 year after GFD. They all underwent HRpQCT scans of distal radius and tibia, areal BMD by DXA, and biochemical tests (bone-specific parameters and CD serology) at both time points. Secondary, we compared 1-year results with those of a control group of healthy premenopausal women of similar age and BMI in order to assess whether the microarchitectural parameters of treated CD patients had reached the values expected for their age. Compared with baseline, the trabecular compartment in the distal radius and tibia improved significantly (trabecular density, trabecular\/bone volume fraction [BV\/TV] [p\u2009&amp;lt;\u20090.0001], and trabecular thickness [p\u2009=\u20090.0004]). Trabecular number remained stable in both regions. Cortical density increased only in the tibia (p\u2009=\u20090.0004). Cortical thickness decreased significantly in both sites (radius: p\u2009=\u20090.03; tibia: p\u2009=\u20090.05). DXA increased in all regions (lumbar spine [LS], p\u2009=\u20090.01; femoral neck [FN], p\u2009=\u20090.009; ultradistal [UD] radius, p\u2009=\u20090.001). Most parameters continued to be significantly lower than those of healthy controls. This prospective HRpQCT study showed that most trabecular parameters altered at CD diagnosis improved significantly by specific treatment (GFD) and calcium and vitamin D supplementation. However, there were still significant differences with a control group of women of similar age and BMI. In the prospective follow-up of this group of patients we expect to be able to assess whether bone microarchitecture attains levels expected for their age. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2922","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T20:06:48Z","timestamp":1469218008000},"page":"135-142","source":"Crossref","is-referenced-by-count":49,"title":["Impaired Bone Microarchitecture Improves After One Year On Gluten-Free Diet: A Prospective Longitudinal HRpQCT Study in Women With Celiac Disease"],"prefix":"10.1093","volume":"32","author":[{"given":"Mar\u00eda Bel\u00e9n","family":"Zanchetta","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Osteolog\u00eda y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Longobardi","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Osteolog\u00eda y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Costa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Longarini","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Mart\u00edn","family":"Mazure","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Laura","family":"Moreno","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Silveira","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Niveloni","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Smecuol","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de la Paz Temprano","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Massari","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Osteolog\u00eda y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Sugai","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo C\u00e9sar","family":"Mauri\u00f1o","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Bogado","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Osteolog\u00eda y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R","family":"Zanchetta","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Osteolog\u00eda y Metabolismo MineralUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas (IDIM)Buenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C\u00e9sar","family":"Bai","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Gastroenterolog\u00eda Facultad de MedicinaUniversidad del SalvadorBuenos AiresArgentina"},{"name":"Secci\u00f3n Intestino DelgadoDepartamento de MedicinaHospital de Gastroenterolog\u00eda \u201cDr. C. Bonorino Udaondo,\u201dBuenos AiresArgentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"2024021014254892500_jbmr2922-bib-0001","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"2024021014254892500_jbmr2922-bib-0002","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"issue":"12","key":"2024021014254892500_jbmr2922-bib-0003","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00198-008-0624-0","article-title":"Bone in celiac disease","volume":"19","author":"Bianchi","year":"2008","journal-title":"Osteoporos Int"},{"issue":"2","key":"2024021014254892500_jbmr2922-bib-0004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11914-016-0304-5","article-title":"Bone and celiac disease","volume":"14","author":"Zanchetta","year":"2016","journal-title":"Curr Osteoporos Rep"},{"key":"2024021014254892500_jbmr2922-bib-0005","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bpg.2015.04.005","article-title":"Therapeutic approaches for celiac disease","volume":"29","author":"Plugis","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"3","key":"2024021014254892500_jbmr2922-bib-0006","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S8756-3282(99)00171-4","article-title":"Bone recovery after a gluten-free diet: a 5-year follow-up study","volume":"25","author":"Kemppainen","year":"1999","journal-title":"Bone"},{"key":"2024021014254892500_jbmr2922-bib-0007","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/8756-3282(94)00034-W","article-title":"Body composition and bone mineral density in untreated and treated patients with celiac disease","volume":"16","author":"Gonz\u00e1lez","year":"1995","journal-title":"Bone"},{"issue":"4","key":"2024021014254892500_jbmr2922-bib-0008","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jocd.2011.06.002","article-title":"Longitudinal evaluation of bone mineral density and body composition in patients with positive celiac serology","volume":"14","author":"Duerksen","year":"2011","journal-title":"J Clin Densitom"},{"issue":"5","key":"2024021014254892500_jbmr2922-bib-0009","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.dld.2011.12.012","article-title":"Bone mass in women with celiac disease: role of exercise and gluten-free diet","volume":"44","author":"Passananti","year":"2012","journal-title":"Dig Liver Dis"},{"key":"2024021014254892500_jbmr2922-bib-0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dld.2007.09.006","article-title":"Systematic review and meta-analysis of observational studies on the prevalence of fractures in coeliac disease","volume":"40","author":"Olmos","year":"2008","journal-title":"Dig Liver Dis"},{"key":"2024021014254892500_jbmr2922-bib-0011","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.3748\/wjg.v17.i25.3035","article-title":"Risk of fractures in celiac disease: gender, dietary compliance or both","volume":"17","author":"","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"16","key":"2024021014254892500_jbmr2922-bib-0012","first-page":"455","article-title":"Executive summary of the 2013 International Society for Clinical Densitometry Position Development Conference on bone densitometry","volume":"2013","author":"Schousboe","journal-title":"J Clin Densitom"},{"key":"2024021014254892500_jbmr2922-bib-0013","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bpg.2005.01.002","article-title":"Bones in coeliac disease: diagnosis and treatment","volume":"19","author":"Corazza","year":"2005","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2024021014254892500_jbmr2922-bib-0014","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2024021014254892500_jbmr2922-bib-0015","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/jbmr.111","article-title":"Bone density, geometry, microstructure and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women","volume":"25","author":"Liu","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2024021014254892500_jbmr2922-bib-0016","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bone.2015.03.005","article-title":"Significant bone microarchitecture impairment in premenopausal women with active celiac disease","volume":"76","author":"Zanchetta","year":"2015","journal-title":"Bone"},{"key":"2024021014254892500_jbmr2922-bib-0017","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/MCG.0b013e31827a6f83","article-title":"World Gastroenterology Organization Global Guidelines on Celiac Disease","volume":"47","author":"Bai","year":"2013","journal-title":"J Clin Gastroenterol"},{"issue":"Suppl 1","key":"2024021014254892500_jbmr2922-bib-0018","first-page":"S448","article-title":"Volumetric BMD and bone microarchitecture are no different between postmenopausal women with osteoporosis or osteopenia with lumbar spine T-score values below \u22122","volume":"24","author":"Zanchetta","year":"2009","journal-title":"J Bone Miner Res"},{"key":"2024021014254892500_jbmr2922-bib-0019","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1359\/jbmr.090822","article-title":"High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone","volume":"25","author":"Liu","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2024021014254892500_jbmr2922-bib-0020","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1359\/jbmr.070514","article-title":"Contribution of in vivo structural measurements and load\/strength ratios to the determination of forearm fracture risk in postmenopausal women","volume":"22","author":"Melton","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024021014254892500_jbmr2922-bib-0021","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jbmr.2796","article-title":"Microarchitecture and peripheral BMD are impaired in postmenopausal Caucasian women with fracture independently of total hip T-score\u2014an international multicenter study","volume":"31","author":"Boutroy","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"2024021014254892500_jbmr2922-bib-0022","first-page":"S43","article-title":"Reproducibility of HR-pQCT measurements in women with normal BMD and postmenopausal women with osteoporosis","volume":"22","author":"Silveira","year":"2011","journal-title":"Osteoporos Int"},{"key":"2024021014254892500_jbmr2922-bib-0023","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1210\/jc.2015-1392","article-title":"Abnormal skeletal strength and microarchitecture in women with celiac disease","volume":"100","author":"Stein","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024021014254892500_jbmr2922-bib-0024","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000369541","article-title":"Extraintestinal manifestations of celiac disease","volume":"33","author":"Pinto-S\u00e1nchez","year":"2015","journal-title":"Dig Dis"},{"key":"2024021014254892500_jbmr2922-bib-0025","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.dld.2009.07.011","article-title":"Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment","volume":"42","author":"Sugai","year":"2010","journal-title":"Dig Liver Dis"},{"issue":"9","key":"2024021014254892500_jbmr2922-bib-0026","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s00198-015-3110-5","article-title":"The relationship between serum 25(OH)D and bone density and microarchitecture as measured by HR-pQCT","volume":"26","author":"Boyd","year":"2015","journal-title":"Osteoporos Int"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2922","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/1\/135\/56652630\/jbmr2922.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/1\/135\/56652630\/jbmr2922.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:57:10Z","timestamp":1710341830000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/32\/1\/135-142\/7605616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12,1]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2922","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12,1]]},"published":{"date-parts":[[2017,12,1]]}}}