{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:07:33Z","timestamp":1772107653037,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH grant","award":["K23 AR059677"],"award-info":[{"award-number":["K23 AR059677"]}]},{"name":"NIH grant","award":["K23 DK100447"],"award-info":[{"award-number":["K23 DK100447"]}]},{"name":"NIH grant","award":["K24 AR055989"],"award-info":[{"award-number":["K24 AR055989"]}]},{"name":"NIH grant","award":["K24 DK091417"],"award-info":[{"award-number":["K24 DK091417"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Prior studies suggest an association between osteoporosis, systemic inflammation, and pro-inflammatory cytokines such as interleukin (IL)-1 and IL-6. Conflicting findings exist on the association between hyperuricemia and osteoporosis. Furthermore, it remains unknown whether gout, a common inflammatory arthritis, affects fracture risk. Using data from a US commercial health plan (2004\u20132013), we evaluated the risk of non-vertebral fracture (ie, forearm, wrist, hip, and pelvis) in patients with gout versus those without. Gout patients were identified with \u22652 diagnosis codes and \u22651 dispensing for a gout-related drug. Non-gout patients, identified with \u22652 visits coded for any diagnosis and \u22651 dispensing for any prescription drugs, were free of gout diagnosis and received no gout-related drugs. Hip fracture was the secondary outcome. Fractures were identified with a combination of diagnosis and procedure codes. Cox proportional hazards models compared the risk of non-vertebral fracture in gout patients versus non-gout, adjusting for more than 40 risk factors for osteoporotic fracture. Among gout patients with baseline serum uric acid (sUA) measurements available, we assessed the risk of non-vertebral fracture associated with sUA. We identified 73,202 gout and 219,606 non-gout patients, matched on age, sex, and the date of study entry. The mean age was 60 years and 82% were men. Over the mean 2-year follow-up, the incidence rate of non-vertebral fracture per 1,000 person-years was 2.92 in gout and 2.66 in non-gout. The adjusted hazard ratio (HR) was 0.98 (95% confidence interval [CI] 0.85\u20131.12) for non-vertebral fracture and 0.83 (95% CI 0.65\u20131.07) for hip fracture in gout versus non-gout. Subgroup analysis (n\u2009=\u200915,079) showed no association between baseline sUA and non-vertebral fracture (HR\u2009=\u20091.03, 95% CI 0.93\u20131.15), adjusted for age, sex, comorbidity score, and number of any prescription drugs. Gout was not associated with a risk of non-vertebral fracture. Among patients with gout, sUA was not associated with the risk of non-vertebral fracture. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2978","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T23:08:20Z","timestamp":1471648100000},"page":"230-236","source":"Crossref","is-referenced-by-count":30,"title":["Gout and the Risk of Non-vertebral Fracture"],"prefix":"10.1093","volume":"32","author":[{"given":"Seoyoung C","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology and AllergyBrigham and Women's HospitalBostonMAUSA"},{"name":"Division of Pharmacoepidemiology and PharmacoeconomicsBrigham and Women's HospitalBostonMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M","family":"Paik","sequence":"additional","affiliation":[{"name":"Division of Renal MedicineBrigham and Women's HospitalBostonMAUSA"},{"name":"Channing Division of Network MedicineBrigham and Women's HospitalBostonMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and PharmacoeconomicsBrigham and Women's HospitalBostonMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary C","family":"Curhan","sequence":"additional","affiliation":[{"name":"Division of Renal MedicineBrigham and Women's HospitalBostonMAUSA"},{"name":"Channing Division of Network MedicineBrigham and Women's HospitalBostonMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and AllergyBrigham and Women's HospitalBostonMAUSA"},{"name":"Division of Pharmacoepidemiology and PharmacoeconomicsBrigham and Women's HospitalBostonMAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"2024021014245060800_jbmr2978-bib-0001"},{"key":"2024021014245060800_jbmr2978-bib-0002","author":"Looker","year":"2015"},{"key":"2024021014245060800_jbmr2978-bib-0003"},{"issue":"2","key":"2024021014245060800_jbmr2978-bib-0004","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.semarthrit.2015.04.014","article-title":"Evolutionary medicine and bone loss in chronic inflammatory diseases\u2014a theory of inflammation-related osteopenia","volume":"45","author":"Straub","year":"2015","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"2024021014245060800_jbmr2978-bib-0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11914-012-0104-5","article-title":"Pathways for bone loss in inflammatory disease","volume":"10","author":"Braun","year":"2012","journal-title":"Curr Osteoporos 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