{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:54:15Z","timestamp":1791287655790,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"INSERM and Assistance Publique-H\u00f4pitaux de Paris","award":["DGE20111123012 EA2496"],"award-info":[{"award-number":["DGE20111123012 EA2496"]}]},{"name":"Paris Descartes for EA2496 and PIV"},{"name":"La Soci\u00e9t\u00e9 Fran\u00e7aise d'Endocrinologie"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise d'Endocrinologie"},{"name":"Elizabeth Huc and Nicolas Perez for their help in breeding the mice; Pauline Gaignard"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>In humans, activating mutations in the PRKAR1A gene cause acrodysostosis 1 (ACRDYS1). These mutations result in a reduction in PKA activation caused by an impaired ability of cAMP to dissociate mutant PRKAR1A from catalytic PKA subunits. Two striking features of this rare developmental disease are renal resistance to PTH and chondrodysplasia resulting from the constitutive inhibition of PTHR1\/Gsa\/AC\/cAMP\/PKA signaling. We developed a knock-in of the recurrent ACRDYS1 R368X PRKAR1A mutation in the mouse. No litters were obtained from [R368X]\/[+] females (thus no homozygous [R368X]\/[R368X] mice). In [R368X]\/[+] mice, Western blot analysis confirmed mutant allele heterozygous expression. Growth retardation, peripheral acrodysostosis (including brachydactyly affecting all digits), and facial dysostosis were shown in [R368X]\/[+] mice by weight curves and skeletal measurements (\u03bcCT scan) as a function of time. [R368X]\/[+] male and female mice were similarly affected. Unexpected, however, whole-mount skeletal preparations revealed a striking delay in mineralization in newborn mutant mice, accompanied by a decrease in the height of terminal hypertrophic chondrocyte layer, an increase in the height of columnar proliferative prehypertrophic chondrocyte layer, and changes in the number and spatial arrangement of proliferating cell nuclear antigen (PCNA)-positive chondrocytes. Plasma PTH and basal urinary cAMP were significantly higher in [R368X]\/[+] compared to WT mice. PTH injection increased urinary cAMP similarly in [R368X]\/[+] and WT mice. PRKACA expression was regulated in a tissue (kidney not bone and liver) manner. This model, the first describing the germline expression of a PRKAR1A mutation causing dominant repression of cAMP-dependent PKA, reproduced the main features of ACRDYS1 in humans. It should help decipher the specificity of the cAMP\/PKA signaling pathway, crucial for numerous stimuli. In addition, our results indicate that PRKAR1A, by tempering intracellular cAMP levels, is a molecular switch at the crossroads of signaling pathways regulating chondrocyte proliferation and differentiation. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2987","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T21:14:10Z","timestamp":1472850850000},"page":"333-346","source":"Crossref","is-referenced-by-count":20,"title":["Knock-In of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis"],"prefix":"10.1093","volume":"32","author":[{"given":"Catherine","family":"Le Stunff","sequence":"first","affiliation":[{"name":"INSERM U1169University Paris Sud, H\u00f4pital Bic\u00eatreLe Kremlin Bic\u00eatreFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Tilotta","sequence":"additional","affiliation":[{"name":"EA 2496 Laboratory Orofacial Pathologies, Imagery and BiotherapiesDental School and Life imaging Platform (PIV), University Paris Descartes Sorbonne Paris Cit\u00e9MontrougeFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Sadoine","sequence":"additional","affiliation":[{"name":"EA 2496 Laboratory Orofacial Pathologies, Imagery and BiotherapiesDental School and Life imaging Platform (PIV), University Paris Descartes Sorbonne Paris Cit\u00e9MontrougeFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Le Denmat","sequence":"additional","affiliation":[{"name":"EA 2496 Laboratory Orofacial Pathologies, Imagery and BiotherapiesDental School and Life imaging Platform (PIV), University Paris Descartes Sorbonne Paris Cit\u00e9MontrougeFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[{"name":"INSERM U1169University Paris Sud, H\u00f4pital Bic\u00eatreLe Kremlin Bic\u00eatreFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Motte","sequence":"additional","affiliation":[{"name":"INSERM U1169University Paris Sud, H\u00f4pital Bic\u00eatreLe Kremlin Bic\u00eatreFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Clauser","sequence":"additional","affiliation":[{"name":"INSERM U970University Paris Descartes, Paris Centre de Recherche Cardiovasculaire (PARCC)ParisFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bougn\u00e8res","sequence":"additional","affiliation":[{"name":"INSERM U1169University Paris Sud, H\u00f4pital Bic\u00eatreLe Kremlin Bic\u00eatreFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chaussain","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Phosphore et du Calcium and Fili\u00e8re de Sant\u00e9 Maladies Rares OSCARAP-HPParisFrance"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) Odontology Department BretonneauLouis Mourier, H\u00f4pitaux Universitaires Paris Nord Val de SeineParisFrance"},{"name":"EA 2496 Laboratory Orofacial Pathologies, Imagery and BiotherapiesDental School and Life imaging Platform (PIV), University Paris Descartes Sorbonne Paris Cit\u00e9MontrougeFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Silve","sequence":"additional","affiliation":[{"name":"Service de Biochimie et G\u00e9n\u00e9tique Mol\u00e9culaire, H\u00f4pital CochinAP-HPParisFrance"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Phosphore et du Calcium and Fili\u00e8re de Sant\u00e9 Maladies Rares OSCARAP-HPParisFrance"},{"name":"INSERM U1169University Paris Sud, H\u00f4pital Bic\u00eatreLe Kremlin Bic\u00eatreFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"issue":"8","key":"2024021014243914300_jbmr2987-bib-0001","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1043-2760(02)00628-8","article-title":"Lessons from constitutively active mutants of G protein-coupled receptors","volume":"13","author":"Parnot","year":"2002","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"2024021014243914300_jbmr2987-bib-0002","first-page":"632","article-title":"The ways in which hormones change cyclic adenosine 3\u2032,5\u2032-monophosphate-dependent protein kinase subunits, and how such changes affect cell behavior","volume":"14","author":"Spaulding","year":"1993","journal-title":"Endocr Rev"},{"key":"2024021014243914300_jbmr2987-bib-0003","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.med.55.091902.103843","article-title":"Inherited diseases involving g proteins and g protein-coupled receptors","volume":"55","author":"Spiegel","year":"2004","journal-title":"Annu Rev Med"},{"issue":"6","key":"2024021014243914300_jbmr2987-bib-0004","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2007.07.018","article-title":"PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"key":"2024021014243914300_jbmr2987-bib-0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1040-7952(97)80019-5","article-title":"Structure, function, and regulation of human cAMP-dependent protein kinases","volume":"31","author":"Tasken","year":"1997","journal-title":"Adv Second Messenger Phosphoprotein Res"},{"key":"2024021014243914300_jbmr2987-bib-0006","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1146\/annurev.bi.59.070190.004543","article-title":"cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes","volume":"59","author":"Taylor","year":"1990","journal-title":"Annu Rev Biochem"},{"key":"2024021014243914300_jbmr2987-bib-0007","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"2024021014243914300_jbmr2987-bib-0008","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiol Rev"},{"issue":"Pt 1","key":"2024021014243914300_jbmr2987-bib-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021698","article-title":"PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization","volume":"370","author":"Houslay","year":"2003","journal-title":"Biochem J"},{"issue":"6","key":"2024021014243914300_jbmr2987-bib-0010","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2008-2333","article-title":"Mutations in regulatory subunit type 1A of cyclic adenosine 5\u2032-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes","volume":"94","author":"Bertherat","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024021014243914300_jbmr2987-bib-0011","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/en.2004-0900","article-title":"Minireview: PRKAR1A: normal and abnormal functions","volume":"145","author":"Bossis","year":"2004","journal-title":"Endocrinology"},{"issue":"23","key":"2024021014243914300_jbmr2987-bib-0012","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa1012717","article-title":"Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance","volume":"364","author":"Linglart","year":"2011","journal-title":"N Engl J Med"},{"key":"2024021014243914300_jbmr2987-bib-0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/bonekey.2012.225","article-title":"Acrodysostosis syndromes","volume":"1","author":"Silve","year":"2012","journal-title":"Bonekey Rep"},{"issue":"6","key":"2024021014243914300_jbmr2987-bib-0014","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/jbmr.2785","article-title":"Screening of PRKAR1A and PDE4D in a large Italian series of patients clinically diagnosed with Albright hereditary osteodystrophy and\/or pseudohypoparathyroidism","volume":"31","author":"Elli","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024021014243914300_jbmr2987-bib-0015","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ajhg.2012.03.004","article-title":"Exome sequencing identifies PDE4D mutations in acrodysostosis","volume":"90","author":"Lee","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2024021014243914300_jbmr2987-bib-0016","doi-asserted-by":"crossref","first-page":"E2328","DOI":"10.1210\/jc.2012-2326","article-title":"PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance","volume":"97","author":"Linglart","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024021014243914300_jbmr2987-bib-0017","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ajhg.2012.03.003","article-title":"Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis","volume":"90","author":"Michot","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2024021014243914300_jbmr2987-bib-0018","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/cge.12106","article-title":"Novel mutations of the PRKAR1A gene in patients with acrodysostosis","volume":"84","author":"Muhn","year":"2013","journal-title":"Clin Genet"},{"issue":"9","key":"2024021014243914300_jbmr2987-bib-0019","doi-asserted-by":"crossref","first-page":"E1808","DOI":"10.1210\/jc.2012-1369","article-title":"PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance","volume":"97","author":"Nagasaki","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"46","key":"2024021014243914300_jbmr2987-bib-0020","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M115.656553","article-title":"Functional characterization of PRKAR1A mutations reveals a unique molecular mechanism causing acrodysostosis but multiple mechanisms causing Carney complex","volume":"290","author":"Rhayem","year":"2015","journal-title":"J Biol Chem"},{"issue":"27","key":"2024021014243914300_jbmr2987-bib-0021","doi-asserted-by":"crossref","first-page":"13111","DOI":"10.1016\/S0021-9258(18)45175-7","article-title":"Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit","volume":"262","author":"Clegg","year":"1987","journal-title":"J Biol Chem"},{"issue":"28","key":"2024021014243914300_jbmr2987-bib-0022","doi-asserted-by":"crossref","first-page":"16672","DOI":"10.1016\/S0021-9258(19)84758-0","article-title":"Functional characterization of cAMP-binding mutations in type I protein kinase","volume":"264","author":"Correll","year":"1989","journal-title":"J Biol Chem"},{"issue":"22","key":"2024021014243914300_jbmr2987-bib-0023","doi-asserted-by":"crossref","first-page":"13321","DOI":"10.1016\/S0021-9258(18)51631-8","article-title":"Expression and characterization of mutant forms of the type I regulatory subunit of cAMP-dependent protein kinase. The effect of defective cAMP binding on holoenzyme activation","volume":"264","author":"Woodford","year":"1989","journal-title":"J Biol Chem"},{"issue":"2","key":"2024021014243914300_jbmr2987-bib-0024","first-page":"65","article-title":"GNAS locus and pseudohypoparathyroidism","volume":"63","author":"Bastepe","year":"2005","journal-title":"Horm Res"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000348516","article-title":"GNAS-related loss-of-function disorders and the role of imprinting","volume":"79","author":"Linglart","year":"2013","journal-title":"Horm Res Paediatr"},{"issue":"1","key":"2024021014243914300_jbmr2987-bib-0026","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/jmedgenet-2013-101937","article-title":"Different mutations in PDE4D associated with developmental disorders with mirror phenotypes","volume":"51","author":"Lindstrand","year":"2014","journal-title":"J Med Genet"},{"issue":"1","key":"2024021014243914300_jbmr2987-bib-0027","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/humu.22222","article-title":"Identification of novel mutations confirms pde4d as a major gene causing acrodysostosis","volume":"34","author":"Lynch","year":"2013","journal-title":"Hum Mutat"},{"key":"2024021014243914300_jbmr2987-bib-0028","doi-asserted-by":"crossref","first-page":"d331","DOI":"10.2741\/A195","article-title":"Specificity in the cAMP\/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA","volume":"2","author":"Skalhegg","year":"1997","journal-title":"Front Biosci"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0029","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by Alcian blue and Alizarin red S","volume":"22","author":"McLeod","year":"1980","journal-title":"Teratology"},{"key":"2024021014243914300_jbmr2987-bib-0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-62703-989-5_17","article-title":"Proliferation assays (BrdU and EdU) on skeletal tissue sections","volume":"1130","author":"Mead","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2024021014243914300_jbmr2987-bib-0031","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/9780470942390.mo150094","article-title":"Analysis of mouse growth plate development","volume":"6","author":"Mangiavini","year":"2016","journal-title":"Curr Protoc Mouse Biol"},{"key":"2024021014243914300_jbmr2987-bib-0032","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1038\/ncomms4673","article-title":"G-protein stimulatory subunit alpha and Gq\/11alpha G-proteins are both required to maintain quiescent stem-like chondrocytes","volume":"5","author":"Chagin","year":"2014","journal-title":"Nat Commun"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0033","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jbmr.2726","article-title":"Claudin-16 deficiency impairs tight junction function in ameloblasts, leading to abnormal enamel formation","volume":"31","author":"Bardet","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2024021014243914300_jbmr2987-bib-0034","doi-asserted-by":"crossref","first-page":"253067","DOI":"10.1155\/2014\/253067","article-title":"Evaluation of growth patterns and body composition in C57Bl\/6J mice using dual energy X-ray absorptiometry","volume":"2014","author":"Gargiulo","year":"2014","journal-title":"Biomed Res Int"},{"issue":"17","key":"2024021014243914300_jbmr2987-bib-0035","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.1117608109","article-title":"Loss of XLalphas (extra-large alphas) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib","volume":"109","author":"Fernandez-Rebollo","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6897","key":"2024021014243914300_jbmr2987-bib-0036","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature00902","article-title":"Functions of FGF signalling from the apical ectodermal ridge in limb development","volume":"418","author":"Sun","year":"2002","journal-title":"Nature"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0037","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ar.a.20308","article-title":"Aspects of achondroplasia in the skulls of dwarf transgenic mice: a cephalometric study","volume":"288","author":"Bloom","year":"2006","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"Pt 1","key":"2024021014243914300_jbmr2987-bib-0038","first-page":"175","article-title":"The timing of ossification of the limb bones, and growth rates of various long bones of the fore and hind limbs of the prenatal and early postnatal laboratory mouse","volume":"186","author":"Patton","year":"1995","journal-title":"J Anat"},{"issue":"5 Pt 2","key":"2024021014243914300_jbmr2987-bib-0039","first-page":"F665","article-title":"Receptors for PTH and PTHrP: their biological importance and functional properties","volume":"277","author":"Mannstadt","year":"1999","journal-title":"Am J Physiol"},{"issue":"2","key":"2024021014243914300_jbmr2987-bib-0040","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1530\/JME-14-0093","article-title":"Role of G-proteins in the differentiation of epiphyseal chondrocytes","volume":"53","author":"Chagin","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"2024021014243914300_jbmr2987-bib-0041","first-page":"441","volume-title":"Genetics of bone biology and skeletal disease","author":"J\u00fcppner","year":"2012"},{"issue":"46","key":"2024021014243914300_jbmr2987-bib-0042","first-page":"2189","volume":"76","author":"Maroteaux","year":"1968","journal-title":"[Acrodysostosis]. Presse Med"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0043","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archpedi.1971.02100140061002","article-title":"Acrodysostosis. A syndrome of peripheral dysostosis, nasal hypoplasia, and mental retardation","volume":"121","author":"Robinow","year":"1971","journal-title":"Am J Dis Child"},{"issue":"4)","key":"2024021014243914300_jbmr2987-bib-0044","doi-asserted-by":"crossref","first-page":"e18772","DOI":"10.1371\/journal.pone.0018772","article-title":"Cell-type specific expression of a dominant negative PKA mutation in mice","volume":"6","author":"Willis","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0045","first-page":"630","article-title":"Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction","volume":"16","author":"Skalhegg","year":"2002","journal-title":"Mol Endocrinol"},{"issue":"19","key":"2024021014243914300_jbmr2987-bib-0046","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1073\/pnas.1003680107","article-title":"Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone","volume":"107","author":"Tsang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2024021014243914300_jbmr2987-bib-0047","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1677\/ERC-09-0068","article-title":"Mouse models of altered protein kinase A signaling","volume":"16","author":"Kirschner","year":"2009","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"2024021014243914300_jbmr2987-bib-0048","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/me.2013-1413","article-title":"Minireview: metabolism of female reproduction: regulatory mechanisms and clinical implications","volume":"28","author":"Seli","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2024021014243914300_jbmr2987-bib-0049","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ydbio.2008.01.018","article-title":"Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest","volume":"316","author":"Vaccari","year":"2008","journal-title":"Dev Biol"},{"issue":"5","key":"2024021014243914300_jbmr2987-bib-0050","first-page":"573","article-title":"A-kinase anchoring proteins: trafficking in G-protein-coupled receptors and the proteins that regulate receptor biology","volume":"10","author":"Malbon","year":"2007","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"1","key":"2024021014243914300_jbmr2987-bib-0051","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00021.2003","article-title":"Localized effects of cAMP mediated by distinct routes of protein kinase A","volume":"84","author":"Tasken","year":"2004","journal-title":"Physiol Rev"},{"issue":"2","key":"2024021014243914300_jbmr2987-bib-0052","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/mi.10.2.6","article-title":"Networking with AKAPs: context-dependent regulation of anchored enzymes","volume":"10","author":"Welch","year":"2010","journal-title":"Mol Interv"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2987","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/2\/333\/56652497\/jbmr2987.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/2\/333\/56652497\/jbmr2987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:57:37Z","timestamp":1710341857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/32\/2\/333-346\/7605594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,2]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,9,2]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2987","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2,1]]},"published":{"date-parts":[[2016,9,2]]}}}