{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:20:20Z","timestamp":1763202020097},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Necrobiotic xanthogranuloma (NXG) is a rare systemic and progressive granulomatous disease first described in 1980. Given no established first-line therapy, treatment focuses on the control of skin lesions and associated complications. Despite it being a granulomatous disease, NXG has not been associated with hypercalcemia. About 140 cases of NXG have been reported to date but, to our knowledge, this is the first case to be complicated by hypercalcemia. Our case confirms a granulomatous disease\u2013mediated production of 1\u03b1-hydroxylase leading to increased synthesis of 1,25-dihydroxyvitamin D and subsequent hypercalcemia. Based on this pathophysiology, we elected to start systemic glucocorticoids, titrated to clinical and metabolic response. Steroid-sparing agents need to be considered to avoid long-term complications but continue controlling this granulomatous disease. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3047","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T13:06:16Z","timestamp":1480079176000},"page":"784-787","source":"Crossref","is-referenced-by-count":8,"title":["Hypercalcemia in Necrobiotic Xanthogranuloma: First Reported Case and Insight Into Treatment"],"prefix":"10.1093","volume":"32","author":[{"given":"Jad G","family":"Sfeir","sequence":"first","affiliation":[{"name":"Department of Medicine and Division of Endocrinology, Diabetes, Metabolism, and NutritionMayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Zogala","sequence":"additional","affiliation":[{"name":"Division of RheumatologyBaylor College of MedicineHoustonTXUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta B","family":"Popii","sequence":"additional","affiliation":[{"name":"Main Line EndocrinologyLankenau Medical CenterWynnewoodPAUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"issue":"3","key":"2024021014203025700_jbmr3047-bib-0001","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0190-9622(80)80189-7","article-title":"Necrobiotic xanthogranuloma with paraproteinemia","volume":"3","author":"Kossard","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"2024021014203025700_jbmr3047-bib-0002","author":"Gelmetti","year":"2012"},{"issue":"3","key":"2024021014203025700_jbmr3047-bib-0003","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archdermatol.2008.583","article-title":"Necrobiotic xanthogranuloma: a review of 17 cases with emphasis on clinical and pathologic correlation","volume":"145","author":"Wood","year":"2009","journal-title":"Arch Dermatol"},{"key":"2024021014203025700_jbmr3047-bib-0004","author":"Sams","year":"1990"},{"issue":"2","key":"2024021014203025700_jbmr3047-bib-0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0021-9150(98)00260-3","article-title":"Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia\u2014a possible pathogenesis of necrobiotic xanthogranuloma","volume":"142","author":"Matsuura","year":"1999","journal-title":"Atherosclerosis"},{"issue":"9","key":"2024021014203025700_jbmr3047-bib-0006","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0161-6420(86)33605-4","article-title":"Necrobiotic xanthogranuloma with paraproteinemia. 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