{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:25Z","timestamp":1792511905756,"version":"4.5.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>We present final results of a study comparing teriparatide 20\u2009\u03bcg every day (QD) with risedronate 35\u2009mg once per week (QW) started within 2 weeks after surgery for a pertrochanteric hip fracture. Patients with BMD T-score\u2009\u2264\u2009\u20132.0 and 25OHD \u22659.2\u2009ng\/mL were randomized to receive 26-week double-dummy treatment plus calcium and vitamin D, followed by 52-week open-label treatment with the same assigned active drug. Primary endpoint was change from baseline in lumbar spine (LS) BMD at 78 weeks. Secondary and exploratory endpoints were change in BMD at the proximal femur, function, hip pain (Charnley score and 100\u2009mm Visual Analog Scale [VAS]), quality of life (Short Form-36), radiology outcomes, and safety. Data were analyzed with mixed models for repeated measures (MMRM) and logistic regression. Totally, 224 patients were randomized; 171 (teriparatide: 86) contributed to the efficacy analyses (mean\u2009\u00b1\u2009SD age: 77\u2009\u00b1\u20097.7 years, 77% females). Mean baseline LS, femoral neck (FN), and total hip (TH) T-scores were \u20132.16, \u20132.63, and \u20132.51, respectively. At 78 weeks, BMD increased significantly more with teriparatide compared to risedronate at the LS (+11.08% versus +6.45%; p\u2009&amp;lt;\u20090.001) and FN (+1.96% versus \u20131.19%; p\u2009=\u20090.003), with no significant between-group difference in TH BMD. Timed up-and-go (TUG) test was significantly faster with teriparatide at 6, 12, 18, and 26 weeks (differences: \u20133.2 to \u20135.9\u2009s; p\u2009=\u20090.045 for overall difference). Hip pain during TUG test by 100\u2009mm VAS was significantly lower with teriparatide at 18 weeks (adjusted difference: \u201311.3\u2009mm, p\u2009=\u20090.033; \u201310.0 and \u20139.3\u2009mm at 12 and 26 weeks, respectively; p\u2009=\u20090.079 for overall difference). Other secondary and exploratory outcomes were not different. Teriparatide group showed two new hip fractures versus seven with risedronate (p\u2009=\u20090.171) and more frequent hypercalcemia and hyperuricemia. In conclusion, 78-week treatment with teriparatide showed significantly greater increases in LS and FN BMD, less pain, and a faster TUG test versus risedronate. \u00a9 2016 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.3067","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T05:43:43Z","timestamp":1482731023000},"page":"1040-1051","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Teriparatide or Risedronate in Elderly Patients With a Recent Pertrochanteric Hip Fracture: Final Results of a 78-Week Randomized Clinical Trial"],"prefix":"10.1093","volume":"32","author":[{"given":"Jorge","family":"Malouf-Sierra","sequence":"first","affiliation":[{"name":"Internal MedicineHospital San PabloBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Orthopaedic SurgeryUniversity Tor VergataRomeItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Osteoporosis CenterUniversity HospitalMonterreyMexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Corradini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental SciencesUniversity of Milan, c\/o 1st University Division of Orthopaedy and TraumatologyASST Gaetano PiniMilanItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and TraumatologyOdense University Hospital Institute of Clinical ResearchUniversity of Southern DenmarkOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J","family":"Stepan","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology and Faculty of MedicineCharles UniversityPragueCzech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Borris","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic SurgeryAarhus University HospitalAarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lespessailles","sequence":"additional","affiliation":[{"name":"Imagerie Multimodale Multi\u00e9chelle et Mod\u00e9lisation du Tissu Osseux (I3MTO), EA 4708Orl\u00e9ans UniversityOrl\u00e9ansFrance"},{"name":"Institut de pr\u00e9vention et de recherche sur l'ost\u00e9oporose (IPROS)Department of RheumatologyCentre Hospitalier R\u00e9gional (CHR) d'Orl\u00e9ansOrl\u00e9ansFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frede","family":"Frihagen","sequence":"additional","affiliation":[{"name":"Orthopaedic SurgeryOslo University HospitalOsloNorway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Papavasiliou","sequence":"additional","affiliation":[{"name":"3rd Orthopaedic DepartmentAristotle University of Thessaloniki, Papageorgiou General HospitalThessalonikiGreece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Petto","sequence":"additional","affiliation":[{"name":"Eli LillyViennaAustria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aspenberg","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental MedicineLink\u00f6ping UniversityLink\u00f6pingSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Caeiro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and TraumatologySantiago de Compostela University HospitalHealth Research InstituteUniversity of Santiago de CompostelaSantiago de CompostelaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Marin","sequence":"additional","affiliation":[{"name":"Eli Lilly Research Centre LtdErl Wood ManorSurreyUK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,26]]},"reference":[{"key":"2024021014192925000_jbmr3067-bib-0001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/PL00004148","article-title":"World-wide projections for hip fracture","volume":"7","author":"Gullberg","year":"1997","journal-title":"Osteoporos Int"},{"key":"2024021014192925000_jbmr3067-bib-0002","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s001980200084","article-title":"Does fracture at one site predict later fractures at other sites","volume":"13","author":"van Staa","year":"2002","journal-title":"A British cohort study. 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