{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:47:59Z","timestamp":1791600479884,"version":"4.3.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK093713"],"award-info":[{"award-number":["K23DK093713"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03DK107869"],"award-info":[{"award-number":["R03DK107869"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Bone &amp; Mineral Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The long\u2010term consequences of bariatric surgery on fracture risk are unclear but are likely to vary by procedure type. In physiologic studies, Roux\u2010en\u2010Y gastric bypass (RYGB) and adjustable gastric banding (AGB) have differential effects on rates of bone loss. Therefore, our objective was to compare fracture risk in obese adults after RYGB and AGB procedures. Using claims data from a US commercial health plan, we analyzed rates of nonvertebral fractures within a propensity score\u2013matched cohort (<jats:italic>n<\/jats:italic>\u2009=\u200915,032) of morbidly obese adults who received either RYGB or AGB surgery between 2005 and 2013. A total of 281 nonvertebral fractures occurred during a mean follow\u2010up time of 2.3\u2009\u00b1\u20091.9 years. RYGB patients had an increased risk of nonvertebral fracture (hazard ratio [HR]\u2009=\u20091.43, 95% confidence interval [CI] 1.13\u20131.81) compared with AGB patients. In fracture site\u2013specific analyses, RYGB patients had increased risk of fracture at the hip (HR\u2009=\u20091.54, 95% CI 1.03\u20132.30) and wrist (HR\u2009=\u20091.45, 95% CI 1.01\u20132.07). Nonvertebral fracture risk associated with RYGB manifested &gt;2 years after surgery and increased in subsequent years, with the highest risk in the fifth year after surgery (HR\u2009=\u20093.91, 95% CI 1.58\u20139.64). In summary, RYGB is associated with a 43% increased risk of nonvertebral fracture compared with AGB, with risk increasing &gt;2 years after surgery. Fracture risk should be considered in risk\/benefit discussions of bariatric surgery, particularly among patients with high baseline risk of osteoporosis who are deciding between RYGB and AGB procedures. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbmr.3101","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T07:42:56Z","timestamp":1488440576000},"page":"1229-1236","source":"Crossref","is-referenced-by-count":116,"title":["Fracture Risk After Bariatric Surgery: Roux\u2010en\u2010Y Gastric Bypass Versus Adjustable Gastric Banding"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-0839","authenticated-orcid":false,"given":"Elaine W","family":"Yu","sequence":"first","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital\/Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moa P","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan E","family":"Landon","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine G","family":"Lindeman","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital\/Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyoung C","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital\/Harvard Medical School Boston MA USA"},{"name":"Division of Rheumatology, Immunology, and Allergy Brigham and Women's Hospital\/Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6458"},{"key":"e_1_2_7_3_1","unstructured":"ASMBS. 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