{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:21Z","timestamp":1790254281019,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR049896, K24 AR 05266, K23 AR054127 and R03 AR064016"],"award-info":[{"award-number":["R01 AR049896, K24 AR 05266, K23 AR054127 and R03 AR064016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Bone &amp; Mineral Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>We have previously reported that premenopausal women with idiopathic osteoporosis (IOP) have profound microarchitectural deficiencies and heterogeneous bone remodeling. Those with the lowest bone formation rate have higher baseline serum insulin\u2010like growth factor\u20101 (IGF\u20101) levels and less robust response to teriparatide. Because IGF\u20101 stimulates bone formation and is critical for teriparatide action on osteoblasts, these findings suggest a state of IGF\u20101 resistance in some IOP women. To further investigate the hypothesis that osteoblast and IGF\u20101\u2010related mechanisms mediate differential responsiveness to teriparatide in IOP, we studied circulating osteoblast progenitor (COP) cells and their IGF\u20101 receptor (IGF\u20101R) expression. In premenopausal women with IOP, peripheral blood mononuclear cells (PBMCs) were obtained at baseline (<jats:italic>n<\/jats:italic>\u2009=\u200925) and over 24 months of teriparatide treatment (<jats:italic>n<\/jats:italic>\u2009=\u200911). Flow cytometry was used to identify and quantify COPs (non\u2010hematopoetic lineage cells expressing osteocalcin and RUNX2) and to quantify IGF\u20101R expression levels. At baseline, both the percent of PBMCs that were COPs (%COP) and COP cell\u2010surface IGF\u20101R expression correlated directly with several histomorphometric indices of bone formation in tetracycline\u2010labeled transiliac biopsies. In treated subjects, both %COP and IGF\u20101R expression increased promptly after teriparatide, returning toward baseline by 18 months. Although neither baseline %COP nor increase in %COP after 3 months predicted the bone mineral density (BMD) response to teriparatide, the percent increase in IGF\u20101R expression on COPs at 3 months correlated directly with the BMD response to teriparatide. Additionally, lower IGF\u20101R expression after teriparatide was associated with higher body fat, suggesting links between teriparatide resistance, body composition, and the GH\/IGF\u20101 axis. In conclusion, these assays may be useful to characterize bone remodeling noninvasively and may serve to predict early response to teriparatide and possibly other bone formation\u2013stimulating medications. These new tools may also have utility in the mechanistic investigation of teriparatide resistance in premenopausal IOP and perhaps in other populations. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbmr.3109","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T12:46:52Z","timestamp":1487594812000},"page":"1267-1273","source":"Crossref","is-referenced-by-count":14,"title":["IGF\u20101 Receptor Expression on Circulating Osteoblast Progenitor Cells Predicts Tissue\u2010Based Bone Formation Rate and Response to Teriparatide in Premenopausal Women With Idiopathic Osteoporosis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-5747","authenticated-orcid":false,"given":"Adi","family":"Cohen","sequence":"first","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Kousteni","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brygida","family":"Bisikirska","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh G","family":"Shah","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Sanil","family":"Manavalan","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Recker","sequence":"additional","affiliation":[{"name":"Creighton University Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Lappe","sequence":"additional","affiliation":[{"name":"Creighton University Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Dempster","sequence":"additional","affiliation":[{"name":"Helen Hayes Hospital West Haverstraw NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Helen Hayes Hospital West Haverstraw NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J","family":"McMahon","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bucovsky","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafo","family":"Kamanda\u2010Kosseh","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Stubby","sequence":"additional","affiliation":[{"name":"Creighton University Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"77","article-title":"Idiopathic osteoporosis: a heterogeneous entity","volume":"149","author":"Heshmati HM","year":"1998","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0996"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2099"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1387"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1172"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044264"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2883"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2682"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.226"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.370"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.03.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1560-y"},{"key":"e_1_2_7_15_1","first-page":"475","volume-title":"Principles and practice of endocrinology and metabolism","author":"Dempster D","year":"2002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0945-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.12.064"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1546"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1666-2"},{"issue":"9","key":"e_1_2_7_21_1","first-page":"2799","article-title":"Insulin\u2010like growth factor\u2010I in men with idiopathic osteoporosis","volume":"82","author":"Kurland ES","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00550.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967090"},{"issue":"4","key":"e_1_2_7_24_1","first-page":"931","article-title":"Treatment with teriparatide might be associated with cardiometabolic changes in postmenopausal severe osteoporotic women","volume":"29","author":"Passeri E","year":"2015","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1126576"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.07.091"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050105"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1376-1"},{"key":"e_1_2_7_29_1","unstructured":"SiddiqueN HealyM ChanCG FallonN WalshJB CaseyMC editors. How to predict a suboptimal response to recombinant parathyroid hormone treatment in osteoporosis. American Society for Bone and Mineral Research Annual Meeting; September 16\u201320 2011; San Diego CA."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.06.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.02.003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe038143"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0353"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070111"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jbmr.3109\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:58:41Z","timestamp":1710341921000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/32\/6\/1267-1273\/7610173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/jbmr.3109"],"URL":"https:\/\/doi.org\/10.1002\/jbmr.3109","archive":["Portico"],"relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}