{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:26:42Z","timestamp":1783042002748,"version":"3.54.6"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Gaucher disease (GD), one of the most common lysosomal disorders (a global population incidence of 1:50,000), is characterized by beta-glucocerebrosidase deficiency. Some studies have demonstrated bone infiltration in up to 80% of patients, even if asymptomatic. Bone disorder remains the main cause of morbidity in these patients, along with osteoporosis, avascular necrosis, and bone infarcts. Enzyme replacement therapy (ERT) has been shown to improve these symptoms. This cross-sectional study included patients with type 1 Gaucher disease (GD1) selected from the Catalan Study Group on GD. Clinical data were collected and a general laboratory workup was performed. Bone mineral density (BMD) was measured at the lumbar spine and hip using dual-energy X-ray absorptiometry (DXA). Patients with bone infarcts or any other focal lesion in the area of indentation visible on imaging were excluded. Bone Material Strength index (BMSi) was measured by bone impact microindentation using an Osteoprobe instrument. Analysis of covariance (ANCOVA) models were fitted to adjust for age, sex, weight, and height. Sixteen patients with GD1 and 29 age- and sex-matched controls were included. GD1 was associated with significantly lower BMSi (adjusted beta \u20139.30; 95% CI, \u201315.18 to \u20133.42; p\u2009=\u20090.004) and reduced lumbar BMD (adjusted beta \u20130.14; 95% CI, \u20130.22 to \u20130.06; p\u2009=\u20090.002) and total hip BMD (adjusted beta \u20130.09; 95% CI, \u20130.15 to \u20130.03; p\u2009=\u20090.006), compared to GD1-free controls. Chitotriosidase levels were negatively correlated with BMSi (linear R2\u2009=\u200951.6%, p\u2009=\u20090.004). Bone tissue mechanical characteristics were deteriorated in patients with GD1. BMSi was correlated with chitotriosidase, the marker of GD activity. Bone disorder requires special consideration in this group of patients, and microindentation could be an appropriate tool for assessing and managing their bone health. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3121","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T12:02:44Z","timestamp":1488801764000},"page":"1575-1581","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation"],"prefix":"10.1093","volume":"32","author":[{"given":"Sabina","family":"Herrera","sequence":"first","affiliation":[{"name":"Internal Medicine DepartmentHospital del Mar Medical Research Institute (IMIM)Universitat Aut\u00f2noma de Barcelona and CIBERFESBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Inborn Errors of Metabolism in AdultsUnit of Rare DiseasesHospital Valle de HebronBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Molt\u00f3-Abad","sequence":"additional","affiliation":[{"name":"Inborn Errors of Metabolism in AdultsUnit of Rare DiseasesHospital Valle de HebronBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"G\u00fcerri-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine DepartmentHospital del Mar Medical Research Institute (IMIM)Universitat Aut\u00f2noma de Barcelona and CIBERFESBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cabezudo","sequence":"additional","affiliation":[{"name":"Hematology DepartmentSant Joan de DeuBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Novelli","sequence":"additional","affiliation":[{"name":"Haematology DepartmentHospital de la Santa Creu i Sant PauBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Haematology DepartmentHospital Cl\u00ednic de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal MedicineHospital Comarcal Sant Jaume de CalellaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Roig","sequence":"additional","affiliation":[{"name":"Department of Hematology and HemotherapyCorporaci\u00f3 Sanit\u00e0ria Parc Taul\u00edBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Solanich","sequence":"additional","affiliation":[{"name":"Internal MedicineHospital Universitari de BellvitgeBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Prieto-Alhambra","sequence":"additional","affiliation":[{"name":"GREMPAL, CIBERFESBarcelonaSpain"},{"name":"National Institute for Health Research (NIHR) Biomedical Research UnitUniversity of OxfordOxfordUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nogu\u00e9s","sequence":"additional","affiliation":[{"name":"Internal Medicine DepartmentHospital del Mar Medical Research Institute (IMIM)Universitat Aut\u00f2noma de Barcelona and CIBERFESBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"D\u00edez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Internal Medicine DepartmentHospital 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