{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:30Z","timestamp":1790899230658,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Beijing Bureau of Health 215 program","award":["2013-3-033; 2009-2-03"],"award-info":[{"award-number":["2013-3-033; 2009-2-03"]}]},{"name":"Beijing Technology Foundation for Selected Overseas Chinese Scholar"},{"name":"Capital Characteristic Clinic Project","award":["Z141107002514072"],"award-info":[{"award-number":["Z141107002514072"]}]},{"name":"Beijing Talents Fund","award":["2015000021467G177"],"award-info":[{"award-number":["2015000021467G177"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>There is little knowledge about the spatial distribution differences in volumetric bone mineral density and cortical bone structure at the proximal femur between femoral neck fractures and trochanteric fractures. In this case-control study, a total of 93 women with fragility hip fractures, 72 with femoral neck fractures (mean\u2009\u00b1\u2009SD age: 70.6\u2009\u00b1\u200912.7 years) and 21 with trochanteric fractures (75.6\u2009\u00b1\u20099.3 years), and 50 control subjects (63.7\u2009\u00b1\u20097.0 years) were included for the comparisons. Differences in the spatial distributions of volumetric bone mineral density, cortical bone thickness, cortical volumetric bone mineral density, and volumetric bone mineral density in a layer adjacent to the endosteal surface were investigated using voxel-based morphometry (VBM) and surface-based statistical parametric mapping (SPM). We compared these spatial distributions between controls and both types of fracture, and between the two types of fracture. Using VBM, we found spatially heterogeneous volumetric bone mineral density differences between control subjects and subjects with hip fracture that varied by fracture type. Interestingly, femoral neck fracture subjects, but not subjects with trochanteric fracture, showed significantly lower volumetric bone mineral density in the superior aspect of the femoral neck compared with controls. Using surface-based SPM, we found that compared with controls, both fracture types showed thinner cortices in regions in agreement with the type of fracture. Most outcomes of cortical and endocortical volumetric bone mineral density comparisons were consistent with VBM results. Our results suggest: 1) that the spatial distribution of trabecular volumetric bone mineral density might play a significant role in hip fracture; 2) that focal cortical bone thinning might be more relevant in femoral neck fractures; and 3) that areas of reduced cortical and endocortical volumetric bone mineral density might be more relevant for trochanteric fractures in Chinese women. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.3150","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T14:26:33Z","timestamp":1492093593000},"page":"1672-1680","source":"Crossref","is-referenced-by-count":37,"title":["Spatial Differences in the Distribution of Bone Between Femoral Neck and Trochanteric Fractures"],"prefix":"10.1093","volume":"32","author":[{"given":"Aihong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of RadiologyBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Carballido-Gamio","sequence":"additional","affiliation":[{"name":"Department of RadiologyUniversity of Colorado DenverDenverCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of RadiologyBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical ImagingUniversity of California, San FranciscoSan FranciscoCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of RadiologyBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedic SurgeryBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedic SurgeryBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedic SurgeryBeijing Jishuitan Hospital, 4th Medical College of Peking UniversityBeijingChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedic 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