{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:40:28Z","timestamp":1791549628982,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. We searched multiple electronic databases to March 2016 for randomized and quasi-randomized controlled trials comparing BK with control treatment (nonsurgical management [NSM], percutaneous vertebroplasty [PV], KIVA VCF treatment system [Benvenue Medical, Inc., Santa Clara, CA, USA], vertebral body stenting, or other) in adults with VCF. Outcomes included back pain, back disability, quality of life, new VCF, and adverse events (AEs). One reviewer extracted data, a second checked accuracy, and two rated risk of bias (ROB). Mean differences and 95% confidence intervals (CIs) were calculated using inverse-variance models. Risk ratios of new VCF and AE were calculated using Mantel-Haenszel models. Ten unique trials enrolled 1837 participants (age range, 61 to 76 years; 74% female), all rated as having high or uncertain ROB. Versus NSM, BK was associated with greater reductions in pain, back-related disability, and better quality of life (k\u2009=\u20091 trial) that appeared to lessen over time, but were less than minimally clinically important differences. Risk of new VCF at 3 and 12 months was not significantly different (k\u2009=\u20092 trials). Risk of any AE was increased at 1 month (RR\u2009=\u20091.73; 95% CI, 1.36 to 2.21). There were no significant differences between BK and PV in back pain, back disability, quality of life, risk of new VCF, or any AE (k\u2009=\u20091 to 3 trials). Limitations included lack of a BK versus sham comparison, availability of only one RCT of BK versus NSM, and lack of study blinding. Individuals with painful VCF experienced symptomatic improvement compared with baseline with all interventions. The clinical importance of the greater improvements with BK versus NSM is unclear, may be due to placebo effect, and may not counterbalance short-term AE risks. Outcomes appeared similar between BK and other surgical interventions. Well-conducted randomized trials comparing BK with sham would help resolve remaining uncertainty about the relative benefits and harms of BK. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3170","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T13:25:24Z","timestamp":1495027524000},"page":"1935-1944","source":"Crossref","is-referenced-by-count":53,"title":["Pain, Quality of Life, and Safety Outcomes of Kyphoplasty for Vertebral Compression Fractures: Report of a Task Force of the American Society for Bone and Mineral Research"],"prefix":"10.1093","volume":"32","author":[{"given":"Alexander J","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Bone and Muscle Health Research GroupDepartment of MedicineSchool of Clinical Sciences at Monash HealthFaculty of Medicine, Nursing and Health SciencesMonash UniversityClaytonAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A","family":"Fink","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical CenterVeterans Affairs Healthcare SystemMinneapolisMNUSA"},{"name":"Division of Epidemiology and Community HealthSchool of Public Healthand Department of MedicineUniversity of MinnesotaMinneapolisMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Mirigian","sequence":"additional","affiliation":[{"name":"American Society for Bone and Mineral Research (ASBMR)WashingtonDCUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gua\u00f1abens","sequence":"additional","affiliation":[{"name":"Rheumatology DepartmentHospital Cl\u00ednicAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS)Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD)University of BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone MetabolismMellanby Centre for Bone ResearchNorthern General Hospital, University of SheffieldSheffieldUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Akesson","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research UnitDepartment of Clinical ScienceUniversity of LundMalmoSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C","family":"Bauer","sequence":"additional","affiliation":[{"name":"School of MedicineUniversity of California, San FranciscoSan FranciscoCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Ebeling","sequence":"additional","affiliation":[{"name":"Australian Institute for Musculoskeletal ScienceSt AlbansAustralia"},{"name":"Melbourne Medical School (Western Campus)University of MelbourneSt AlbansAustralia"},{"name":"Bone and Muscle Health Research GroupDepartment of MedicineSchool of Clinical Sciences at Monash HealthFaculty of Medicine, Nursing and Health SciencesMonash UniversityClaytonAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"issue":"5 Suppl","key":"2024021014195562700_jbmr3170-bib-0001","article-title":"The worldwide problem of osteoporosis: insights afforded by epidemiology","volume":"17","author":"Riggs","year":"1995","journal-title":"Bone"},{"issue":"2a","key":"2024021014195562700_jbmr3170-bib-0002","article-title":"Clinical consequences of vertebral fractures","volume":"103","author":"Ross","year":"1997","journal-title":"Am J Med"},{"issue":"3 Supplement","key":"2024021014195562700_jbmr3170-bib-0003","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.injury.2007.08.010","article-title":"Nonoperative management of osteoporotic vertebral compression fractures","volume":"38","author":"Prather","year":"2007","journal-title":"Injury"},{"issue":"7","key":"2024021014195562700_jbmr3170-bib-0004","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2106\/JBJS.L.00024","article-title":"Vertebral body stenting versus kyphoplasty for the treatment of osteoporotic vertebral compression fractures: a randomized trial","volume":"95","author":"Werner","year":"2013","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"2024021014195562700_jbmr3170-bib-0005","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/BRS.0b013e31826b3aef","article-title":"Balloon kyphoplasty versus KIVA vertebral augmentation\u2014comparison of 2 techniques for osteoporotic vertebral body fractures: a prospective randomized study","volume":"38","author":"Korovessis","year":"2013","journal-title":"Spine"},{"issue":"17","key":"2024021014195562700_jbmr3170-bib-0006","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1056\/NEJMcp1009697","article-title":"Clinical practice. 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