{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:00:50Z","timestamp":1787864450934,"version":"build-2784847793"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35-DE026602"],"award-info":[{"award-number":["R35-DE026602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DE021420"],"award-info":[{"award-number":["R01-DE021420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00-DE022059"],"award-info":[{"award-number":["R00-DE022059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Bettencourt-Schueller, Institut Servier"},{"name":"Fondation des Gueules-Cass\u00e9es, Fondation Philippe"},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dept. of Health and Human Services\/NIH S10 Shared Instrumentation Grant","award":["S10RR026645"],"award-info":[{"award-number":["S10RR026645"]}]},{"name":"Departments of Preventive and Restorative Dental Sciences"},{"name":"Orofacial Sciences, School of Dentistry, UCSF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Rodents are characterized by continuously renewing incisors whose growth is fueled by epithelial and mesenchymal stem cells housed in the proximal compartments of the tooth. The epithelial stem cells reside in structures known as the labial (toward the lip) and lingual (toward the tongue) cervical loops (laCL and liCL, respectively). An important feature of the rodent incisor is that enamel, the outer, highly mineralized layer, is asymmetrically distributed, because it is normally generated by the laCL but not the liCL. Here, we show that epithelial-specific deletion of the transcription factor Islet1 (Isl1) is sufficient to drive formation of ectopic enamel by the liCL stem cells, and also that it leads to production of altered enamel on the labial surface. Molecular analyses of developing and adult incisors revealed that epithelial deletion of Isl1 affected multiple, major pathways: Bmp (bone morphogenetic protein), Hh (hedgehog), Fgf (fibroblast growth factor), and Notch signaling were upregulated and associated with liCL-generated ectopic enamel; on the labial side, upregulation of Bmp and Fgf signaling, and downregulation of Shh were associated with premature enamel formation. Transcriptome profiling studies identified a suite of differentially regulated genes in developing Isl1 mutant incisors. Our studies demonstrate that ISL1 plays a central role in proper patterning of stem cell\u2013derived enamel in the incisor and indicate that this factor is an important upstream regulator of signaling pathways during tooth development and renewal. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3202","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T11:16:36Z","timestamp":1498475796000},"page":"2219-2231","source":"Crossref","is-referenced-by-count":19,"title":["<i>Isl1<\/i> Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor"],"prefix":"10.1093","volume":"32","author":[{"given":"Adrien","family":"Naveau","sequence":"first","affiliation":[{"name":"INSERM U872ParisFrance"},{"name":"Centre de Recherche des CordeliersUniversit\u00e9 Pierre et Marie CurieUMR S872ParisFrance"},{"name":"Universit\u00e9 Paris DescartesSorbonne Paris CiteUMR S872ParisFrance"},{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdongChina"},{"name":"Department of Oral and Maxillofacial Surgery, Guanghua School of StomatologyHospital of Stomatology, Sun Yat-sen UniversityGuangzhouGuangdongChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Meng","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McGarrett T","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Prochazkova","sequence":"additional","affiliation":[{"name":"Laboratory of Transgenic Models of DiseasesInstitute of Molecular Genetics of the ASCRv.v.i., PragueCzech Republic"},{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wen","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Marangoni","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle B","family":"Jones","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C","family":"Cox","sequence":"additional","affiliation":[{"name":"Center for Developmental Biology and Regenerative MedicineSeattle Children's Research InstituteSeattleWAUSA"},{"name":"Department of Pediatrics (Craniofacial Medicine)University of WashingtonSeattleWAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ganss","sequence":"additional","affiliation":[{"name":"Faculty of DentistryUniversity of TorontoTorontoONCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H","family":"Jheon","sequence":"additional","affiliation":[{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophir D","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Institute for Human GeneticsUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"},{"name":"Program in Craniofacial Biology and Department of Orofacial SciencesUCSF School of DentistryUniversity of CaliforniaSan FranciscoSan Francisco, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0001","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/wdev.63","article-title":"From molecules to mastication: the development and evolution of teeth","volume":"2","author":"Jheon","year":"2013","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0002","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1083\/jcb.147.1.105","article-title":"Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling","volume":"147","author":"Harada","year":"1999","journal-title":"J Cell Biol"},{"issue":"22","key":"2024021014192572800_jbmr3202-bib-0003","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1242\/dev.056358","article-title":"Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor","volume":"137","author":"Seidel","year":"2010","journal-title":"Development"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ydbio.2012.03.012","article-title":"E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor","volume":"366","author":"Li","year":"2012","journal-title":"Dev Biol"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.devcel.2012.05.012","article-title":"Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors","volume":"23","author":"Juuri","year":"2012","journal-title":"Dev Cell"},{"issue":"7","key":"2024021014192572800_jbmr3202-bib-0006","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ncb2766","article-title":"BMI1 represses Ink4a\/Arf and Hox genes to regulate stem cells in the rodent incisor","volume":"15","author":"Biehs","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"4","key":"2024021014192572800_jbmr3202-bib-0007","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/ar.1091830405","article-title":"Cellular renewal in the enamel organ and the odontoblast layer of the rat incisor as followed by radioautography using 3H-thymidine","volume":"183","author":"Smith","year":"1975","journal-title":"Anat Rec"},{"issue":"4","key":"2024021014192572800_jbmr3202-bib-0008","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/aja.1001420402","article-title":"Histological and three dimensional organization of the odontogenic organ in the lower incisor of 100 gram rats","volume":"142","author":"Smith","year":"1975","journal-title":"Am J Anat"},{"issue":"4","key":"2024021014192572800_jbmr3202-bib-0009","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ar.1091790403","article-title":"Morphological classification of rat incisor ameloblasts","volume":"179","author":"Warshawsky","year":"1974","journal-title":"Anat Rec"},{"issue":"21","key":"2024021014192572800_jbmr3202-bib-0010","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/dev.125.21.4325","article-title":"FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development","volume":"125","author":"Bei","year":"1998","journal-title":"Development"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1006\/dbio.1998.9092","article-title":"Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation","volume":"204","author":"Mitsiadis","year":"1998","journal-title":"Dev Biol"},{"issue":"6","key":"2024021014192572800_jbmr3202-bib-0012","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1242\/dev.129.6.1533","article-title":"FGF10 maintains stem cell compartment in developing mouse incisors","volume":"129","author":"Harada","year":"2002","journal-title":"Development"},{"issue":"Suppl 1","key":"2024021014192572800_jbmr3202-bib-0013","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/03008200390152205","article-title":"Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teeth","volume":"44","author":"Millar","year":"2003","journal-title":"Connect Tissue Res"},{"issue":"5","key":"2024021014192572800_jbmr3202-bib-0014","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.devcel.2004.09.012","article-title":"Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation","volume":"7","author":"Wang","year":"2004","journal-title":"Dev Cell"},{"issue":"6)","key":"2024021014192572800_jbmr3202-bib-0015","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1371\/journal.pbio.0050159","article-title":"An integrated gene regulatory network controls stem cell proliferation in teeth","volume":"5","author":"Wang","year":"2007","journal-title":"PLoS Biol"},{"issue":"4\u20135","key":"2024021014192572800_jbmr3202-bib-0016","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.diff.2010.06.004","article-title":"Notch signalling is required for the survival of epithelial stem cells in the continuously growing mouse incisor","volume":"80","author":"Felszeghy","year":"2010","journal-title":"Differentiation"},{"issue":"9","key":"2024021014192572800_jbmr3202-bib-0017","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/0022034510370090","article-title":"beta-Catenin initiates tooth neogenesis in adult rodent incisors","volume":"89","author":"Liu","year":"2010","journal-title":"J Dent Res"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0018","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1242\/dev.015081","article-title":"An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors","volume":"135","author":"Klein","year":"2008","journal-title":"Development"},{"issue":"5","key":"2024021014192572800_jbmr3202-bib-0019","doi-asserted-by":"crossref","first-page":"e37670","DOI":"10.1371\/journal.pone.0037670","article-title":"BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor","volume":"7","author":"Kyrylkova","year":"2012","journal-title":"PLoS One"},{"issue":"6269","key":"2024021014192572800_jbmr3202-bib-0020","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/344879a0","article-title":"Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain","volume":"344","author":"Karlsson","year":"1990","journal-title":"Nature"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0021","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80985-X","article-title":"Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation","volume":"84","author":"Pfaff","year":"1996","journal-title":"Cell"},{"issue":"6","key":"2024021014192572800_jbmr3202-bib-0022","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary","volume":"125","author":"Ericson","year":"1998","journal-title":"Development"},{"issue":"3","key":"2024021014192572800_jbmr3202-bib-0023","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2337\/db12-0952","article-title":"Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor","volume":"62","author":"Hunter","year":"2013","journal-title":"Diabetes"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0024","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.devcel.2012.06.005","article-title":"The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity","volume":"23","author":"Witzel","year":"2012","journal-title":"Dev Cell"},{"issue":"20","key":"2024021014192572800_jbmr3202-bib-0025","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1242\/dev.065359","article-title":"Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice","volume":"138","author":"Kawakami","year":"2011","journal-title":"Development"},{"issue":"7026","key":"2024021014192572800_jbmr3202-bib-0026","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03215","article-title":"Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages","volume":"433","author":"Laugwitz","year":"2005","journal-title":"Nature"},{"issue":"6","key":"2024021014192572800_jbmr3202-bib-0027","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2006.10.029","article-title":"Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification","volume":"127","author":"Moretti","year":"2006","journal-title":"Cell"},{"issue":"7251","key":"2024021014192572800_jbmr3202-bib-0028","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature08191","article-title":"Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages","volume":"460","author":"Bu","year":"2009","journal-title":"Nature"},{"issue":"6","key":"2024021014192572800_jbmr3202-bib-0029","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev Cell"},{"issue":"3","key":"2024021014192572800_jbmr3202-bib-0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.stem.2015.08.007","article-title":"The Isl1\/Ldb1 complex orchestrates genome-wide chromatin organization to instruct differentiation of multipotent cardiac progenitors","volume":"17","author":"Caputo","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0031","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/0022034514556815","article-title":"Early dental epithelial transcription factors distinguish ameloblastoma from keratocystic odontogenic tumor","volume":"94","author":"Heikinheimo","year":"2015","journal-title":"J Dent Res"},{"key":"2024021014192572800_jbmr3202-bib-0032","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1472-6831-12-57","article-title":"Genome-wide association scan of dental caries in the permanent dentition","volume":"12","author":"Wang","year":"2012","journal-title":"BMC Oral Health"},{"issue":"18","key":"2024021014192572800_jbmr3202-bib-0033","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1242\/dev.00631","article-title":"Role of Islet1 in the patterning of murine dentition","volume":"130","author":"Mitsiadis","year":"2003","journal-title":"Development"},{"issue":"7","key":"2024021014192572800_jbmr3202-bib-0034","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"issue":"6","key":"2024021014192572800_jbmr3202-bib-0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10735-014-9580-5","article-title":"Genome-wide analysis of gene expression in human embryonic tooth germ","volume":"45","author":"Huang","year":"2014","journal-title":"J Mol Histol"},{"issue":"22","key":"2024021014192572800_jbmr3202-bib-0036","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"Dassule","year":"2000","journal-title":"Development"},{"issue":"11","key":"2024021014192572800_jbmr3202-bib-0037","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1242\/dev.010751","article-title":"ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells","volume":"135","author":"Pan","year":"2008","journal-title":"Development"},{"issue":"4","key":"2024021014192572800_jbmr3202-bib-0038","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"9","key":"2024021014192572800_jbmr3202-bib-0039","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"2024021014192572800_jbmr3202-bib-0040","doi-asserted-by":"crossref","first-page":"D749","DOI":"10.1093\/nar\/gkt1196","article-title":"Ensembl 2014","volume":"42","author":"Flicek","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2024021014192572800_jbmr3202-bib-0041","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0042","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2024021014192572800_jbmr3202-bib-0044","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0960-9822(01)00143-9","article-title":"Zebrafish pea3 and erm are general targets of FGF8 signaling","volume":"11","author":"Roehl","year":"2001","journal-title":"Curr Biol"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.devcel.2006.05.014","article-title":"Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling","volume":"11","author":"Klein","year":"2006","journal-title":"Dev Cell"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0046","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0167-4889(92)90173-9","article-title":"Follistatin inhibits activin-induced differentiation of rat follicular granulosa cells in vitro","volume":"1135","author":"Nakamura","year":"1992","journal-title":"Biochim Biophys Acta"},{"issue":"6520","key":"2024021014192572800_jbmr3202-bib-0047","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/374360a0","article-title":"Multiple defects and perinatal death in mice deficient in follistatin","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"issue":"4919","key":"2024021014192572800_jbmr3202-bib-0048","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.2672330","article-title":"Morphogenesis of the polarized epithelial cell phenotype","volume":"245","author":"Rodriguez-Boulan","year":"1989","journal-title":"Science"},{"issue":"5","key":"2024021014192572800_jbmr3202-bib-0049","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/ar.20683","article-title":"Differential expression of the tight junction proteins, claudin-1, claudin-4, occludin, ZO-1, and PAR3, in the ameloblasts of rat upper incisors","volume":"291","author":"Inai","year":"2008","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0714.2006.00497.x","article-title":"Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth","volume":"36","author":"Bello","year":"2007","journal-title":"J Oral Pathol Med"},{"issue":"11","key":"2024021014192572800_jbmr3202-bib-0051","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1242\/dev.126.11.2335","article-title":"Otx1 and Otx2 activities are required for the normal development of the mouse inner ear","volume":"126","author":"Morsli","year":"1999","journal-title":"Development"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0052","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5115\/acb.2011.44.1.69","article-title":"Identification of genes concordantly expressed with Atoh1 during inner ear development","volume":"44","author":"Yoon","year":"2011","journal-title":"Anat Cell Biol"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0053","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1172\/JCI32723","article-title":"Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2\/Stat3 pathway in murine models of stroke","volume":"118","author":"Shyu","year":"2008","journal-title":"J Clin Invest"},{"issue":"4","key":"2024021014192572800_jbmr3202-bib-0054","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1091\/mbc.e04-08-0664","article-title":"The LIM\/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities","volume":"16","author":"Hao","year":"2005","journal-title":"Mol Biol Cell"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1677\/JOE-08-0294","article-title":"A possible role of osteocalcin in the regulation of insulin secretion: human in vivo evidence","volume":"199","author":"Kassi","year":"2008","journal-title":"J Endocrinol"},{"issue":"12","key":"2024021014192572800_jbmr3202-bib-0056","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.4161\/cc.4.12.2207","article-title":"PTPRV is a key mediator of p53-induced cell cycle exit","volume":"4","author":"Doumont","year":"2005","journal-title":"Cell Cycle"},{"issue":"Pt 8","key":"2024021014192572800_jbmr3202-bib-0057","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1242\/jcs.000067","article-title":"Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling","volume":"120","author":"Hayashi","year":"2007","journal-title":"J Cell Sci"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0058","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1074\/mcp.M114.042242","article-title":"Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans","volume":"14","author":"Lundberg","year":"2015","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0059","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jbmr.2591","article-title":"Inhibition of Notch signaling during mouse incisor renewal leads to enamel defects","volume":"31","author":"Jheon","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0060","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbrc.2005.12.053","article-title":"Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling","volume":"340","author":"Harada","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2024021014192572800_jbmr3202-bib-0061","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/dvdy.21001","article-title":"Expression of claudins in murine tooth development","volume":"236","author":"Ohazama","year":"2007","journal-title":"Dev Dyn"},{"issue":"7","key":"2024021014192572800_jbmr3202-bib-0062","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1601-0825.2007.01427.x","article-title":"Claudin rather than occludin is essential for differentiation in rat incisor odontoblasts","volume":"14","author":"Hoshino","year":"2008","journal-title":"Oral Dis"},{"issue":"3","key":"2024021014192572800_jbmr3202-bib-0063","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jbmr.2726","article-title":"Claudin-16 deficiency impairs tight junction function in ameloblasts, leading to abnormal enamel formation","volume":"31","author":"Bardet","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024021014192572800_jbmr3202-bib-0064","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02547385","article-title":"The secretory stage of amelogenesis in rat mandibular incisor teeth observed by scanning electron microscopy","volume":"21","author":"Skobe","year":"1976","journal-title":"Calcif Tissue Res"},{"key":"2024021014192572800_jbmr3202-bib-0065","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.24712","article-title":"Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis","volume":"6","author":"Seidel","year":"2017","journal-title":"eLife"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/11\/2219\/56649828\/jbmr3202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/32\/11\/2219\/56649828\/jbmr3202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:59:19Z","timestamp":1710341959000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/32\/11\/2219-2231\/7605240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,26]]},"references-count":65,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,6,26]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3202","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11,1]]},"published":{"date-parts":[[2017,6,26]]}}}