{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:05:29Z","timestamp":1792098329645,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Periostin is a matricellular protein involved in bone formation and bone matrix organization, but it is also produced by other tissues. Its circulating levels have been weakly associated with bone microstructure and prevalent fractures, possibly because periostin measured by the current commercial assays does not specifically reflect bone metabolism. In this context, we developed a new ELISA for a periostin fragment resulting from cathepsin K digestion (K-Postn). We hypothesized that circulating K-Postn levels could be associated with bone fragility. A total of 695 women (age 65.0\u2009\u00b1\u20091.5 years), enrolled in the Geneva Retirees Cohort (GERICO), were prospectively evaluated over 4.7\u2009\u00b1\u20091.9 years for the occurrence of low-trauma fractures. At baseline, we measured serum periostin, K-Postn, and bone turnover markers (BTMs), distal radius and tibia microstructure by HR-pQCT, hip and lumbar spine aBMD by DXA, and estimated fracture probability using the Fracture Risk Assessment Tool (FRAX). Sixty-six women sustained a low-trauma clinical fracture during the follow-up. Total periostin was not associated with fractures (HR [95% CI] per SD: 1.19 [0.89 to 1.59], p\u2009=\u20090.24). In contrast, K-Postn was significantly higher in the fracture versus nonfracture group (57.5\u2009\u00b1\u200936.6\u2009ng\/mL versus 42.5\u2009\u00b1\u200923.4\u2009ng\/mL, p\u2009&amp;lt;\u20090.001) and associated with fracture risk (HR [95%CI] per SD: 2.14 [1.54 to 2.97], p\u2009&amp;lt;\u20090.001). After adjustment for aBMD, FRAX, bone microstructure, or BTMs, K-Postn remained significantly associated with fracture risk. The performance of the fracture prediction models was improved by adding K-Postn to aBMD or FRAX (Harrell\u2009C index for fracture: 0.70 for aBMD\u2009+\u2009K-Post versus 0.58 for aBMD alone, p\u2009=\u20090.001; 0.73 for FRAX\u2009+\u2009K-Postn versus 0.65 for FRAX alone, p\u2009=\u20090.005). Circulating K-Postn predicts incident fractures independently of BMD, BTMs, and FRAX in postmenopausal women. Hence measurement of a periostin fragment resulting from in vivo cathepsin K digestion may help to identify subjects at high risk of fracture. \u00a9 2017 American Society for Bone and Mineral Research<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3203","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T09:39:49Z","timestamp":1501666789000},"page":"2232-2238","source":"Crossref","is-referenced-by-count":25,"title":["Serum Levels of a Cathepsin-K Generated Periostin Fragment Predict Incident Low-Trauma Fractures in Postmenopausal Women Independently of BMD and FRAX"],"prefix":"10.1093","volume":"32","author":[{"given":"Nicolas","family":"Bonnet","sequence":"first","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Biver","sequence":"additional","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Chevalley","sequence":"additional","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Garnero","sequence":"additional","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge L","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Bone DiseasesDepartment of Internal Medicine SpecialtiesGeneva University Hospital & Faculty of MedicineGenevaSwitzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"issue":"11","key":"2024021014192134500_jbmr3203-bib-0001","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1359\/jbmr.2003.18.11.1947","article-title":"BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic 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turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study","volume":"14","author":"Garnero","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024021014192134500_jbmr3203-bib-0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos Int"},{"issue":"6","key":"2024021014192134500_jbmr3203-bib-0006","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jbmr.2796","article-title":"Microarchitecture and peripheral BMD are impaired in postmenopausal white women with fracture independently of total hip T-score: an international multicenter study","volume":"31","author":"Boutroy","year":"2016","journal-title":"J Bone Miner 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