{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:51:11Z","timestamp":1790293871649,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH090072"],"award-info":[{"award-number":["R01MH090072"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["2UL1TR000442\u201006"],"award-info":[{"award-number":["2UL1TR000442\u201006"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The purpose of this study was to prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Every 4 months, trabecular and cortical volumetric bone mineral density (vBMD) at the radius and markers of bone metabolism were evaluated. Every 8 months, total body less head areal bone mineral content and lumbar spine (LS) areal BMD (aBMD) were determined. Linear mixed-effects regression analysis examined associations between bone measures on the one hand and MDD, GAD, and SSRI indices on the other. A total of 264 participants were followed for 1.51\u2009\u00b1\u20090.76 years. After adjusting for age, sex, vitamin D concentration, physical activity, lean mass or grip strength, and time in the study, MDD severity was associated with increasing LS aBMD. Similarly, SSRI use was associated with increasing LS aBMD and bone formation in female participants. In contrast, SSRI use was associated with decreasing LS aBMD in males. After accounting for depression, GAD was independently, albeit weakly, associated with increased bone mineralization. In older adolescents and emerging adults, MDD and GAD are associated with increasing bone mass, particularly in the lumbar spine and in females, whereas SSRIs are associated with increasing bone mass in females but decreasing bone mass in males. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3238","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:56:01Z","timestamp":1502956561000},"page":"2367-2374","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Depression, Generalized Anxiety, and Selective Serotonin Reuptake Inhibitors on Change in Bone Metabolism in Adolescents and Emerging Adults"],"prefix":"10.1093","volume":"32","author":[{"given":"Chadi A","family":"Calarge","sequence":"first","affiliation":[{"name":"Baylor College of MedicineHoustonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Mills","sequence":"additional","affiliation":[{"name":"University of IowaIowa CityIAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen F","family":"Janz","sequence":"additional","affiliation":[{"name":"University of IowaIowa CityIAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy L","family":"Burns","sequence":"additional","affiliation":[{"name":"University of IowaIowa CityIAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A","family":"Schlechte","sequence":"additional","affiliation":[{"name":"University of IowaIowa CityIAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Coryell","sequence":"additional","affiliation":[{"name":"University of IowaIowa CityIAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S","family":"Zemel","sequence":"additional","affiliation":[{"name":"The University of PennsylvaniaPhiladelphiaPAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"2024021014195060200_jbmr3238-bib-0001","year":"2013"},{"issue":"8)","key":"2024021014195060200_jbmr3238-bib-0002","doi-asserted-by":"crossref","first-page":"e00489","DOI":"10.1002\/brb3.489","article-title":"Bone density and depressive disorder: a meta-analysis","volume":"6","author":"Schweiger","year":"2016","journal-title":"Brain Behav"},{"issue":"5","key":"2024021014195060200_jbmr3238-bib-0003","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.biopsych.2009.03.016","article-title":"Major depression is a risk factor for low bone mineral density: a meta-analysis","volume":"66","author":"Yirmiya","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2024021014195060200_jbmr3238-bib-0004","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","year":"2001","journal-title":"JAMA"},{"issue":"4","key":"2024021014195060200_jbmr3238-bib-0005","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-015-3440-3","article-title":"The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos Int"},{"issue":"8","key":"2024021014195060200_jbmr3238-bib-0006","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tem.2009.05.003","article-title":"Depression as a risk factor for osteoporosis","volume":"20","author":"Cizza","year":"2009","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"2024021014195060200_jbmr3238-bib-0007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bone.2009.07.083","article-title":"Effects of selective serotonin reuptake inhibitors on bone health in adults: time for recommendations about screening, prevention and management","volume":"46","author":"Haney","year":"2010","journal-title":"Bone"},{"issue":"10","key":"2024021014195060200_jbmr3238-bib-0008","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/nm.4166","article-title":"Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect","volume":"22","author":"Ortuno","year":"2016","journal-title":"Nat Med"},{"key":"2024021014195060200_jbmr3238-bib-0009","doi-asserted-by":"crossref","DOI":"10.1111\/jgs.14936","article-title":"Bone turnover with venlafaxine treatment in older adults with depression","author":"Rawson","year":"2017","journal-title":"J Am Geriatr Soc. 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