{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:27:46Z","timestamp":1768469266884,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["602300"],"award-info":[{"award-number":["602300"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Hajdu-Cheney syndrome (HCS) is a rare autosomal-dominant disorder primarily characterized by acro-osteolysis and early-onset osteoporosis. Genetically, HCS is caused by nonsense or deletion mutations within exon 34 of the NOTCH2 gene, resulting in premature translational termination and production of C-terminally truncated NOTCH2 proteins that are predicted to activate NOTCH2-dependent signaling. To understand the role of Notch2 in bone remodeling, we developed a mouse model of HCS by introducing a pathogenic mutation (6272delT) into the murine Notch2 gene. By \u03bcCT and undecalcified histology, we observed generalized osteopenia in two independent mouse lines derived by injection of different targeted embryonic stem (ES) cell clones, yet acro-osteolysis did not occur until the age of 52 weeks. Cellular and dynamic histomorphometry revealed a high bone turnover situation in Notch2+\/HCS mice, since osteoblast and osteoclast indices were significantly increased compared with wild-type littermates. Whereas ex vivo cultures failed to uncover cell-autonomous gain-of-functions within the osteoclast or osteoblast lineage, an unbiased RNA sequencing approach identified Tnfsf11 and Il6 as Notch-signaling target genes in bone marrow cells cultured under osteogenic conditions. Because we further observed that the high-turnover pathology of Notch2+\/HCS mice was fully normalized by alendronate treatment, our results demonstrate that mutational activation of Notch2 does not directly control osteoblast activity but favors a pro-osteoclastic gene expression pattern, which in turn triggers high bone turnover. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3283","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T11:33:47Z","timestamp":1504179227000},"page":"70-83","source":"Crossref","is-referenced-by-count":24,"title":["High Bone Turnover in Mice Carrying a Pathogenic Notch2 Mutation Causing Hajdu-Cheney Syndrome"],"prefix":"10.1093","volume":"33","author":[{"given":"Nele","family":"Vollersen","sequence":"first","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irm","family":"Hermans-Borgmeyer","sequence":"additional","affiliation":[{"name":"Center for Molecular NeurobiologyUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Cornils","sequence":"additional","affiliation":[{"name":"Research Department Cell and Gene TherapyDepartment of Stem Cell TransplantationUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Fehse","sequence":"additional","affiliation":[{"name":"Research Department Cell and Gene TherapyDepartment of Stem Cell TransplantationUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Rolvien","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Triviai","sequence":"additional","affiliation":[{"name":"Clinic for Stem Cell TransplantationUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Jeschke","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Oheim","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center 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