{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:43:33Z","timestamp":1762674213424},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after 2 years. We assessed bone strength, microarchitecture, and bone mineral density (BMD) of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12, and 24 months using high-resolution pQCT (Scanco Medical, Br\u00fcttisellen, Switzerland) in 104 girls (aged 11.0\u2009\u00b1\u20091.7 years; 47 Fx, 57 Non-Fx) and 157 boys (aged 12.7\u2009\u00b1\u20091.7 years; 86 Fx, 71 Non-Fx). Bone outcomes included total area (Tt.Ar) and bone mineral density (Tt.BMD), trabecular bone volume ratio (BV\/TV), thickness (Tb.Th), separation (Tb.Sp), and number (Tb.N), and cortical BMD (Ct.BMD), thickness (Ct.Th), and porosity (Ct.Po). We used finite element analysis to estimate bone strength (failure load [F.Load]; ultimate stress [U.Stress]; load-to-strength ratio). We used sex-specific mixed-effects models to compare bone outcomes between Fx and Non-Fx over 2 years. In girls, those with fractures had 18% to 24% lower U.Stress and 5% to 9% lower Tt.BMD than Non-Fx at all time points (p\u2009&amp;lt;\u20090.017). In secondary analysis by fracture degree, girls with low-energy (LE) fractures had 19% to 21% lower F.Load, 25% to 47% lower U.Stress, 11% to 14% lower Tt.BMD, and 11% to 15% lower BV\/TV than Non-Fx at all time points (p\u2009&amp;lt;\u20090.017). In contrast, boys\u2019 bone outcomes were similar between Fx and Non-Fx at all time points. In secondary analysis by fracture degree, boys with LE fractures had 10% lower Tt.BMD and 10% lower Ct.Th compared with Non-Fx at 12 months only. Deficits in distal radius bone strength and trabecular bone microarchitecture appear to track across 2 years after a forearm fracture in girls but not in boys. Longer follow-up is needed to determine whether deficits persist into adulthood in women and how they may influence future risk of fragility fracture. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3307","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T14:34:42Z","timestamp":1507818882000},"page":"229-240","source":"Crossref","is-referenced-by-count":9,"title":["Bone Strength in Girls and Boys After a Distal Radius Fracture: A 2-Year HR-pQCT Double Cohort Study"],"prefix":"10.1093","volume":"33","author":[{"given":"Heather M","family":"Macdonald","sequence":"first","affiliation":[{"name":"Department of Family PracticeUniversity of British ColumbiaVancouverCanada"},{"name":"Centre for Hip Health and MobilityVancouver Coastal Health Research InstituteVancouverCanada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"M\u00e4\u00e4tt\u00e4","sequence":"additional","affiliation":[{"name":"Department of OrthopedicsUniversity of British ColumbiaVancouverCanada"},{"name":"Centre for Hip Health and MobilityVancouver Coastal Health Research InstituteVancouverCanada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Gabel","sequence":"additional","affiliation":[{"name":"Centre for Hip Health and MobilityVancouver Coastal Health Research InstituteVancouverCanada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishore","family":"Mulpuri","sequence":"additional","affiliation":[{"name":"Department of Orthopedic SurgeryBritish Columbia Children's HospitalVancouverCanada"},{"name":"Department of OrthopedicsUniversity of British ColumbiaVancouverCanada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of OrthopedicsUniversity of British ColumbiaVancouverCanada"},{"name":"Department of Family PracticeUniversity of British ColumbiaVancouverCanada"},{"name":"Centre for Hip Health and MobilityVancouver Coastal Health Research InstituteVancouverCanada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"2024021014391156800_jbmr3307-bib-0001","first-page":"1","article-title":"Fracture patterns in children. 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