{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T19:32:49Z","timestamp":1781379169664,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Use of active forms of vitamin D is advocated in patients with chronic kidney disease (CKD) for treatment of mineral bone disease because of the presumption that native forms of vitamin D would not undergo significant activation to calcitriol, the most active biological form of vitamin D. We present secondary analysis looking at bone turnover in subjects who completed the randomized, double blind, placebo-controlled trial investigating the effect of cholecalciferol supplementation on vascular function in nondiabetic CKD stage G3\u00adG4 and vitamin D \u226420\u2009ng\/mL (Clinical Trials Registry of India: CTRI\/2013\/05\/003648). Patients were randomized (1:1) to receive either two directly observed oral doses of 300,000 IU of cholecalciferol or matching placebo at baseline and 8 weeks. Of the 120 subjects enrolled, 58 in the cholecalciferol group and 59 in the placebo group completed the study. At 16 weeks, the serum 25(OH)D and 1,25(OH)2D levels increased in the cholecalciferol group but not in the placebo group (between-group difference in mean change: 23.40\u2009ng\/mL; 95% CI, 19.76 to 27.06; p\u2009&amp;lt;\u20090.001, and 14.98\u2009pg\/mL; 95% CI, 4.48 to 27.18; p\u2009=\u20090.007, respectively). Intact parathyroid hormone (iPTH) decreased in the cholecalciferol group (between-group difference in mean change \u2013100.73\u2009pg\/mL (95% CI, \u2013150.50 to \u201350.95; p\u2009&amp;lt;\u20090.001). Serum total and bone-specific alkaline phosphatase (SAP, BAP) and serum C-terminal cross-linked collagen type I telopeptides (CTX-1) were significantly reduced in cholecalciferol group (between group difference for change in mean: \u201320.25\u2009U\/L; 95% CI, \u201335.14 to \u20135.38\u2009U\/L; p\u2009=\u20090.008 for SAP; \u201312.54\u2009U\/L; 95% CI, \u201322.09 to \u20132.98\u2009U\/L; p\u2009=\u20090.013 for BAP; and \u20130.21\u2009ng\/mL; 95% CI, \u20130.38 to \u20130.05\u2009ng\/mL; p\u2009=\u20090.05 for CTX-1). Correlation analysis showed significant correlation of \u039425(OH)D with \u0394iPTH (r\u2009=\u2009\u20130.409, p\u2009&amp;lt;\u20090.0001), \u03941,25(OH)2D (r\u2009=\u20090.305, p\u2009=\u20090.001), \u0394SAP (r\u2009=\u2009\u20130.301, p\u2009=\u20090.002), \u0394BAP (r\u2009=\u2009\u20130.264, p\u2009=\u20090.004), and \u0394CTX-1 (r\u2009=\u2009\u20130.210, p\u2009=\u20090.0230). Cholecalciferol supplementation corrects vitamin D deficiency and is effective in lowering serum intact parathyroid hormone and bone turnover markers in early stages of CKD. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3314","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T11:02:42Z","timestamp":1508238162000},"page":"404-409","source":"Crossref","is-referenced-by-count":37,"title":["The Effect of Vitamin D Supplementation on Bone Metabolic Markers in Chronic Kidney Disease"],"prefix":"10.1093","volume":"33","author":[{"given":"Ashok Kumar","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of NephrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of NephrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of NephrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Sciences Research InstituteSt GeorgesUniversity of LondonUK"},{"name":"Renal and Transplantation UnitSt George's University Hospitals National Health Service (NHS) Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan Lal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of NephrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"George Institute for Global HealthUniversity of Oxford, OxfordUK"},{"name":"The George Institute for Global HealthNew DelhiIndia"},{"name":"Department of NephrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"issue":"10","key":"2024021014375012200_jbmr3314-bib-0001","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/ndt\/gft514","article-title":"Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome","volume":"29","author":"Cozzolino","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"2024021014375012200_jbmr3314-bib-0002","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1053\/j.ajkd.2003.12.003","article-title":"Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy","volume":"43","author":"Martin","year":"2004","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"2024021014375012200_jbmr3314-bib-0003","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"issue":"4","key":"2024021014375012200_jbmr3314-bib-0004","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2215\/CJN.06040710","article-title":"Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options","volume":"6","author":"Cunningham","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"2024021014375012200_jbmr3314-bib-0005","first-page":"514","article-title":"Chronic kidney disease\u2014mineral and bone disorder: a complex scenario","volume":"31","author":"Mejia","year":"2011","journal-title":"Nefrologia"},{"issue":"4","key":"2024021014375012200_jbmr3314-bib-0006","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/j.ajkd.2011.04.029","article-title":"Association of kidney function, vitamin D deficiency, and circulating markers of mineral and bone disorders in CKD","volume":"58","author":"Urena-Torres","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"2024021014375012200_jbmr3314-bib-0007","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1681\/ASN.2017010003","article-title":"A randomized trial of vitamin D supplementation on vascular function in CKD","volume":"28","author":"Kumar","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2024021014375012200_jbmr3314-bib-0008","first-page":"32","article-title":"Coates PM; Vitamin D Standardization Program (VDSP). 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