{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:16:50Z","timestamp":1760908610249},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T00:00:00Z","timestamp":1294185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"DOI":"10.1002\/jbmr.335","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T15:50:56Z","timestamp":1294242656000},"page":"239-241","source":"Crossref","is-referenced-by-count":17,"title":["Discontinuation of odanacatib and other osteoporosis treatments: Here today and gone tomorrow?"],"prefix":"10.1093","volume":"26","author":[{"given":"Douglas C","family":"Bauer","sequence":"first","affiliation":[{"name":"Departments of Medicine and Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"2024020318044781300_bib1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.7326\/0003-4819-149-6-200809160-00007","article-title":"Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians","volume":"149","author":"Qaseem","year":"2008","journal-title":"Ann Intern Med."},{"key":"2024020318044781300_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00198-008-0813-x","article-title":"To stop or not to stop, that is the question","volume":"20","author":"Seeman","year":"2009","journal-title":"Osteoporos Int."},{"issue":"(2 suppl)","key":"2024020318044781300_bib3","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.amjmed.2008.12.004","article-title":"Safety of bisphosphonates in the treatment of osteoporosis","volume":"122","author":"Recker","year":"2009","journal-title":"Am J Med."},{"key":"2024020318044781300_bib4","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1001\/jama.296.24.2927","article-title":"Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial","volume":"296","author":"Black","year":"2006","journal-title":"JAMA."},{"issue":"(suppl 1)","key":"2024020318044781300_bib5","article-title":"The effect of 3 versus 6 years of zoledronic acid treatment in osteoporosis: a randomized extension to the HORIZON Pivotal Fracture Trial (PFT)","volume":"25","author":"Black","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jbmr.212","article-title":"Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect","volume":"26","author":"Eisman","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/sj.clpt.6100450","article-title":"Cathepsin K inhibitors: a novel target for osteoporosis therapy","volume":"83","author":"Stoch","year":"2008","journal-title":"Clin Pharmacol Ther."},{"key":"2024020318044781300_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/clpt.2009.60","article-title":"Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies","volume":"86","author":"Stoch","year":"2009","journal-title":"Clin Pharmacol Ther."},{"key":"2024020318044781300_bib9","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1359\/jbmr.091035","article-title":"Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density","volume":"25","author":"Bone","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1359\/jbmr.2003.18.5.859","article-title":"The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation","volume":"18","author":"Garnero","year":"2003","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib11","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1359\/JBMR.050215","article-title":"Femoral neck bone loss predicts fracture risk independent of baseline BMD","volume":"20","author":"Nguyen","year":"2005","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jbmr.5650110307","article-title":"Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis","volume":"11","author":"Garnero","year":"1996","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib13","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1359\/JBMR.040326","article-title":"Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial Long-Term Extension","volume":"19","author":"Ensrud","year":"2004","journal-title":"J Bone Miner Res."},{"key":"2024020318044781300_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00198-007-0460-7","article-title":"Fracture risk remains reduced one year after discontinuation of risedronate","volume":"19","author":"Watts","year":"2008","journal-title":"Osteoporos Int."},{"issue":"(suppl 1)","key":"2024020318044781300_bib15","article-title":"Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass","volume":"24","author":"Bone","year":"2009","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.335","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/2\/239\/56559088\/335_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/2\/239\/56559088\/335_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:00:44Z","timestamp":1710342044000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/26\/2\/239-241\/7598118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,5]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,1,5]]},"published-print":{"date-parts":[[2011,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.335","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,2,1]]},"published":{"date-parts":[[2011,1,5]]}}}