{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:56:34Z","timestamp":1789642594531,"version":"4.0.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","award":["Belavy 2014\u20102017"],"award-info":[{"award-number":["Belavy 2014\u20102017"]}],"id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Marrow adipose tissue (MAT) accumulation with normal aging impacts the bone, hemopoiesis, and metabolic pathways. We investigated whether exercise was associated with lower MAT, as measured by vertebral marrow fat fraction (VFF) on magnetic resonance imaging. A total of 101 healthy individuals (54 females) aged 25 to 35 years without spine or bone disease but with distinct exercise histories were studied. Long-distance runners (67\u2009km\/wk, n\u2009=\u200925) exhibited lower mean lumbar VFF (27.9% [8.6%] versus 33.5% [6.0%]; p\u2009=\u20090.0048) than non-sporting referents (n\u2009=\u200924). In habitual joggers (28\u2009km\/wk, n\u2009=\u200930), mean lumbar VFF was 31.3% (9.0%) (p\u2009=\u20090.22 versus referents) and 6.0 percentage points lower than referents at vertebrae T10, T11, and T12 (p\u2009\u2264\u20090.023). High-volume road cycling (275\u2009km\/wk, n\u2009=\u200922) did not impact VFF. 3D accelerations corresponding to faster walking, slow jogging, and high-impact activities correlated with lower VFF, whereas low-impact activities and sedentary time correlated with higher mean lumbar VFF (all p\u2009\u2264\u20090.05). Given an estimated adipose bone marrow conversion of 7% per decade of life, long distance runners, with 5.6 percentage points lower VFF, showed an estimated 8-year younger vertebral marrow adipose tissue phenotype. Regression analysis showed a 0.7 percentage point reduction in mean lumbar VFF with every 9.4\u2009km\/wk run (p\u2009=\u20090.002). This study presents the first evidence in humans or animals that specific volumes and types of exercise may influence the age-determined adipose marrow conversion and result in low MAT. These results identify a potentially modifiable risk factor for prevalent chronic conditions related to bone metabolism, hemopoietic production, and other metabolic functions with potential global health applications. \u00a9 2017 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3357","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T06:02:47Z","timestamp":1516082567000},"page":"651-657","source":"Crossref","is-referenced-by-count":38,"title":["Specific Modulation of Vertebral Marrow Adipose Tissue by Physical Activity"],"prefix":"10.1093","volume":"33","author":[{"given":"Daniel L","family":"Belavy","sequence":"first","affiliation":[{"name":"Deakin UniversityInstitute for Physical Activity and NutritionSchool of Exercise and Nutrition SciencesGeelongAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Quittner","sequence":"additional","affiliation":[{"name":"Deakin UniversityInstitute for Physical Activity and NutritionSchool of Exercise and Nutrition SciencesGeelongAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola D","family":"Ridgers","sequence":"additional","affiliation":[{"name":"Deakin UniversityInstitute for Physical Activity and NutritionSchool of Exercise and Nutrition SciencesGeelongAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Shiekh","sequence":"additional","affiliation":[{"name":"Department of RadiologyThe Ottawa HospitalUniversity of OttawaOttawaCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Rantalainen","sequence":"additional","affiliation":[{"name":"Deakin UniversityInstitute for Physical Activity and NutritionSchool of Exercise and Nutrition SciencesGeelongAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Trudel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Physical Medicine and RehabilitationBone and Joint Research Laboratory, University of OttawaOttawaCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"2024021014360278800_jbmr3357-bib-0001","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.169.3942.291","article-title":"Bone marrow histogenesis: a comparison of fatty and red marrow","volume":"169","author":"Tavassoli","year":"1970","journal-title":"Science"},{"key":"2024021014360278800_jbmr3357-bib-0002","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fendo.2016.00085","article-title":"Bone marrow adipose tissue: to be or not to be a typical adipose 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