{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:31:17Z","timestamp":1793215877255,"version":"4.5.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":2175,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The Screening for Osteoporosis in Older Women for the Prevention of Fracture (SCOOP) study was a community-based screening intervention in women aged 70 to 85 years in the United Kingdom. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including bone mineral density measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic, and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other. All analyses were conducted on an intention-to-treat basis, based on the group to which women were randomized, irrespective of whether screening was completed. Of 12,483 eligible participants, 6233 women were randomized to screening, with treatment recommended in 898 (14.4%). No evidence of an effect or interaction was observed for the outcomes of any fracture or osteoporotic fracture. In the screening arm, 54 fewer hip fractures were observed than in the control arm (164 versus 218, 2.6% versus 3.5%), and commensurate with treatment being targeted to those at highest hip fracture risk, the effect on hip fracture increased with baseline FRAX hip fracture probability (p\u2009=\u20090.021 for interaction); for example, at the 10th percentile of baseline FRAX hip probability (2.6%), there was no evidence that hip fractures were reduced (hazard ratio [HR]\u2009=\u20090.93; 95% confidence interval [CI] 0.71 to 1.23), but at the 90th percentile (16.6%), there was a 33% reduction (HR\u2009=\u20090.67; 95% CI 0.53 to 0.84). Prior fracture and parental history of hip fracture positively influenced screening effectiveness on hip fracture risk. We conclude that women at high risk of hip fracture based on FRAX probability are responsive to appropriate osteoporosis management. \u00a9 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3411","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T11:03:12Z","timestamp":1519642992000},"page":"1020-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Management of Patients With High Baseline Hip Fracture Risk by FRAX Reduces Hip Fractures\u2014A Post Hoc Analysis of the SCOOP Study"],"prefix":"10.1093","volume":"33","author":[{"given":"Eugene","family":"McCloskey","sequence":"first","affiliation":[{"name":"Mellanby Centre for Bone ResearchCentre for Integrated Research in Musculoskeletal AgeingUniversity of Sheffieldand Sheffield Teaching Hospitals Foundation TrustSheffieldUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Johansson","sequence":"additional","affiliation":[{"name":"Australian Catholic UniversityMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas C","family":"Harvey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit and NIHR Southampton Nutrition Biomedical Research CentreUniversity of Southamptonand University Hospital Southampton NHS Foundation TrustSouthamptonUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shepstone","sequence":"additional","affiliation":[{"name":"Norwich Medical SchoolUniversity of East AngliaNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lenaghan","sequence":"additional","affiliation":[{"name":"Norwich Medical SchoolUniversity of East AngliaNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ric","family":"Fordham","sequence":"additional","affiliation":[{"name":"Norwich Medical SchoolUniversity of East AngliaNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Harvey","sequence":"additional","affiliation":[{"name":"Norwich Medical SchoolUniversity of East AngliaNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Howe","sequence":"additional","affiliation":[{"name":"Norwich Medical SchoolUniversity of East AngliaNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"NIHR Musculoskeletal Biomedical Research UnitUniversity of OxfordOxfordUK"},{"name":"MRC Lifecourse Epidemiology Unit and NIHR Southampton Nutrition Biomedical Research CentreUniversity of Southamptonand University Hospital Southampton NHS Foundation TrustSouthamptonUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of RheumatologyUniversity Hospitals BristolBristolUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gittoes","sequence":"additional","affiliation":[{"name":"Centre for EndocrinologyDiabetes, and MetabolismQueen Elizabeth HospitalBirminghamUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Heawood","sequence":"additional","affiliation":[{"name":"Bristol Medical SchoolUniversity of BristolBristolUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Holland","sequence":"additional","affiliation":[{"name":"Leicester Medical SchoolCentre for MedicineUniversity of LeicesterLeicesterUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarnya","family":"Marshall","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University HospitalNorwichUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence W","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Centre for EpidemiologyManchester Academic Health Science CentreThe University of Manchesterand NIHR Manchester Biomedical Research CentreCentral Manchester University Hospitals NHS Foundation TrustManchesterUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J","family":"Peters","sequence":"additional","affiliation":[{"name":"Bristol Medical SchoolUniversity of BristolBristolUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Redmond","sequence":"additional","affiliation":[{"name":"Bristol Medical SchoolUniversity of BristolBristolUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Torgerson","sequence":"additional","affiliation":[{"name":"Department of Health SciencesUniversity of YorkYorkUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Kanis","sequence":"additional","affiliation":[{"name":"Centre for Metabolic Bone DiseasesUniversity of Sheffield, Sheffield, UKand Australian Catholic UniversityMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SCOOP Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"issue":"1","key":"2024021014274422300_jbmr3411-bib-0001","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11657-016-0278-z","article-title":"A systematic review of intervention thresholds based on FRAX: a report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation","volume":"11","author":"Kanis","year":"2016","journal-title":"Arch Osteoporos"},{"issue":"4","key":"2024021014274422300_jbmr3411-bib-0002","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the 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