{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:58Z","timestamp":1762459558600,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Reduced bone mineral density (BMD) may be due to reduced mineralized bone matrix volume, incomplete secondary mineralization, or reduced primary mineralization. Because bone biopsy is invasive, we hypothesized that noninvasive image acquisition at high resolution can accurately quantify matrix mineral density (MMD). Quantification of MMD was confined to voxels attenuation photons above 80% of that produced by fully mineralized bone matrix because attenuation at this level is due to variation in mineralization, not porosity. To assess accuracy, 9 cadaveric distal radii were imaged at a voxel size of 82 microns using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT, Scanco Medical AG, Bruttisellen, Switzerland) and compared with VivaCT 40 (\u00b5CT) at 19-micron voxel size. Associations between MMD and porosity were studied in 94 healthy vitamin D\u2013replete premenopausal women, 77 postmenopausal women, and in a 27-year-old woman with vitamin D\u2013dependent rickets (VDDR). Microstructure and MMD were quantified using StrAx (StraxCorp, Melbourne, Australia). MMD measured by HR-pQCT and \u00b5CT correlated (R\u2009=\u20090.87; p\u2009&amp;lt;\u20090.0001). The precision error for MMD was 2.43%. Cortical porosity and MMD were associated with age (r2\u2009=\u20090.5 and \u20130.4, respectively) and correlated inversely in pre- and postmenopausal women (both r2\u2009=\u20090.9, all p\u2009&amp;lt;\u20090.001). Porosity was higher, and MMD was lower, in post- than in premenopausal women (porosity 40.3%\u2009\u00b1\u20097.0 versus 34.7%\u2009\u00b1\u20093.5, respectively; MMD 65.4%\u2009\u00b1\u20091.8 versus 66.6%\u2009\u00b1\u20091.4, respectively, both p &amp;lt; 0.001). In the woman with VDDR, MMD was 5.6 SD lower and porosity was 5.6 SD higher than the respective trait means in premenopausal women. BMD was reduced (Z-scores femoral neck \u20134.3 SD, lumbar spine \u20133.8 SD). Low-radiation HR-pQCT may facilitate noninvasive quantification of bone's MMD and microstructure in health, disease, and during treatment. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3415","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T14:22:59Z","timestamp":1519827779000},"page":"1312-1317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cortical Matrix Mineral Density Measured Noninvasively in Pre- and Postmenopausal Women and a Woman With Vitamin D\u2013Dependent Rickets"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9392-6771","authenticated-orcid":false,"given":"Cherie Y","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Zebaze","sequence":"additional","affiliation":[{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ghasem-Zadeh","sequence":"additional","affiliation":[{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D","family":"Zajac","sequence":"additional","affiliation":[{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ego","family":"Seeman","sequence":"additional","affiliation":[{"name":"Institute of Health and AgeingAustralian Catholic UniversityMelbourneAustralia"},{"name":"Department of MedicineUniversity of MelbourneParkvilleAustralia"},{"name":"Department of EndocrinologyAustin HealthHeidelbergAustralia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"issue":"10","key":"2024021014333366500_jbmr3415-bib-0001","first-page":"1134","article-title":"Assessment of bone mineral. Part 1","volume":"25","author":"Wahner","year":"1984","journal-title":"J Nucl Med"},{"issue":"4","key":"2024021014333366500_jbmr3415-bib-0002","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00774-009-0146-7","article-title":"Mineral maturity and crystallinity index are distinct characteristics of bone mineral","volume":"28","author":"Farlay","year":"2010","journal-title":"J Bone Miner Metab"},{"issue":"5","key":"2024021014333366500_jbmr3415-bib-0003","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1359\/jbmr.070203","article-title":"Seasonal change in osteoid thickness and mineralization lag time in ambulant patients","volume":"22","author":"Need","year":"2007","journal-title":"J Bone Miner Metab"},{"issue":"2","key":"2024021014333366500_jbmr3415-bib-0004","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients","volume":"25","author":"Priemel","year":"2010","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"2024021014333366500_jbmr3415-bib-0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0025-6196(12)61395-0","article-title":"Outpatient percutaneous biopsy of the iliac crest: methods, morbidity, and patient acceptance","volume":"61","author":"Hodgson","year":"1986","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"2024021014333366500_jbmr3415-bib-0006","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00223-008-9158-x","article-title":"Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography","volume":"83","author":"Burghardt","year":"2008","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"2024021014333366500_jbmr3415-bib-0007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1359\/jbmr.071116","article-title":"In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging","volume":"23","author":"Kazakia","year":"2008","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"2024021014333366500_jbmr3415-bib-0008","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bone.2013.01.007","article-title":"A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images","volume":"54","author":"Zebaze","year":"2013","journal-title":"Bone"},{"issue":"6","key":"2024021014333366500_jbmr3415-bib-0009","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bone.2011.02.023","article-title":"Differences in the degree of bone tissue mineralization account for little of the differences in tissue elastic properties","volume":"48","author":"Zebaze","year":"2011","journal-title":"Bone"},{"issue":"1","key":"2024021014333366500_jbmr3415-bib-0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jbmr.2315","article-title":"Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study","volume":"30","author":"Tsai","year":"2015","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"2024021014333366500_jbmr3415-bib-0011","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jbmr.2057","article-title":"Lower cortical porosity and higher tissue mineral density in Chinese American versus white women","volume":"29","author":"Boutroy","year":"2014","journal-title":"J Bone Miner Metab"},{"issue":"7","key":"2024021014333366500_jbmr3415-bib-0012","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1118\/1.2924210","article-title":"Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements","volume":"35","author":"Kazakia","year":"2008","journal-title":"Med Phys"},{"issue":"4","key":"2024021014333366500_jbmr3415-bib-0013","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jbmr.2388","article-title":"Trabecular and cortical microstructure and fragility of the distal radius in women","volume":"30","author":"Bala","year":"2015","journal-title":"J Bone Miner Metab"},{"issue":"6","key":"2024021014333366500_jbmr3415-bib-0014","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1359\/jbmr.2003.18.6.1012","article-title":"Aging of microstructural compartments in human compact bone","volume":"18","author":"Akkus","year":"2003","journal-title":"J Bone Miner Metab"},{"issue":"11","key":"2024021014333366500_jbmr3415-bib-0015","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1359\/jbmr.080607","article-title":"Vitamin D metabolites and calcium absorption in severe vitamin D deficiency","volume":"23","author":"Need","year":"2008","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"2024021014333366500_jbmr3415-bib-0016","doi-asserted-by":"crossref","first-page":"E436","DOI":"10.1210\/jc.2010-1886","article-title":"Relationship between vitamin D, parathyroid hormone, and bone health","volume":"96","author":"Sai","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024021014333366500_jbmr3415-bib-0017","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/jbmr.261","article-title":"Bone morphology in response to alendronate as seen by high-resolution computed tomography: through a glass darkly","volume":"25","author":"Seeman","year":"2010","journal-title":"J Bone Miner Metab"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/7\/1312\/56651600\/jbmr3415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/7\/1312\/56651600\/jbmr3415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:01:27Z","timestamp":1710342087000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/33\/7\/1312-1317\/7605476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,2,28]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3415","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"type":"print","value":"0884-0431"},{"type":"electronic","value":"1523-4681"}],"subject":[],"published-other":{"date-parts":[[2018,7,1]]},"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"2017-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}