{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:59:30Z","timestamp":1792115970469,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Defense award","award":["W81XWH-12-1-0364"],"award-info":[{"award-number":["W81XWH-12-1-0364"]}]},{"name":"NIH awards","award":["U01 TR001082"],"award-info":[{"award-number":["U01 TR001082"]}]},{"name":"NIH awards","award":["P30 DK092718"],"award-info":[{"award-number":["P30 DK092718"]}]},{"name":"Eastern Colorado VA Geriatric Research, Education, and Clinical Center"},{"name":"T32","award":["AG000279"],"award-info":[{"award-number":["AG000279"]}]},{"name":"T32","award":["DK007658"],"award-info":[{"award-number":["DK007658"]}]},{"name":"T32","award":["DK007658"],"award-info":[{"award-number":["DK007658"]}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum iCa during exercise prevents increases in PTH and carboxy-terminal collagen crosslinks (CTX). Eleven cycling-trained men (aged 18 to 45 years) underwent two identical 60-min cycling bouts with infusion of Ca gluconate or saline. Blood sampling for iCa, total calcium (tCa), PTH, CTX, and procollagen type 1 amino-terminal propeptide (P1NP) occurred before, during, and for 4 hours after exercise; results are presented as unadjusted and adjusted for plasma volume shifts (denoted with subscript ADJ). iCa decreased during exercise with saline infusion (p\u2009=\u20090.01 at 60\u2009min) and this was prevented by Ca infusion (interaction, p\u2009&amp;lt;\u20090.007); there were abrupt decreases in Ca content (iCaADJ and tCaADJ) in the first 15\u2009min of exercise under both conditions. PTH and CTX were increased at the end of exercise (both p\u2009&amp;lt;\u20090.01) on the saline day, and markedly attenuated (\u201365% and \u201371%; both p\u2009&amp;lt;\u20090.001) by Ca. CTX remained elevated for 4 hours after exercise on the saline day (p\u2009&amp;lt;\u20090.001), despite the return of PTH to baseline by 1 hour after exercise. P1NP increased in response to exercise (p\u2009&amp;lt;\u20090.001), with no difference between conditions, but the increase in P1NPADJ was not significant. Results for PTHADJ and CTXADJ were similar to unadjusted results. These findings demonstrate that bone resorption is stimulated early in exercise to defend serum iCa. Vascular Ca content decreased early in exercise, but neither the reason why this occurred, nor the fate of Ca, are known. The results suggest that the exercise-induced increase in PTH had an acute catabolic effect on bone. Future research should determine whether the increase in PTH generates an anabolic response that occurs more than 4 hours after exercise. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3428","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T01:30:18Z","timestamp":1521855018000},"page":"1326-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses"],"prefix":"10.1093","volume":"33","author":[{"given":"Wendy M","family":"Kohrt","sequence":"first","affiliation":[{"name":"Eastern Colorado Geriatric ResearchEducation, and Clinical CenterVA Eastern Colorado Healthcare SystemDenverCOUSA"},{"name":"Division of Geriatric MedicineDepartment of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Wherry","sequence":"additional","affiliation":[{"name":"Division of Geriatric MedicineDepartment of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and BiometricsUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa D","family":"Sherk","sequence":"additional","affiliation":[{"name":"Division of EndocrinologyMetabolism, and Diabetes, Department of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Wellington","sequence":"additional","affiliation":[{"name":"Division of Geriatric MedicineDepartment of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Swanson","sequence":"additional","affiliation":[{"name":"Division of EndocrinologyMetabolism, and Diabetes, Department of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie M","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Nutrition ScienceCollege of Health and Human SciencesPurdue UniversityWest LafayetteINUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S","family":"Boxer","sequence":"additional","affiliation":[{"name":"Eastern Colorado Geriatric ResearchEducation, and Clinical CenterVA Eastern Colorado Healthcare SystemDenverCOUSA"},{"name":"Division of Geriatric MedicineDepartment of MedicineUniversity of Colorado Anschutz Medical CampusAuroraCOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"issue":"3","key":"2024021014332336400_jbmr3428-bib-0001","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1359\/JBMR.041119","article-title":"Femoral neck structure in adult female athletes subjected to different loading modalities","volume":"20","author":"Nikander","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2024021014332336400_jbmr3428-bib-0002","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1519\/JSC.0000000000000785","article-title":"Bone mineral content and density among female NCAA Division I athletes across the competitive season and over a multi-year time frame","volume":"30","author":"Stanforth","year":"2016","journal-title":"J Strength Cond Res"},{"issue":"5","key":"2024021014332336400_jbmr3428-bib-0003","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00198-012-2142-3","article-title":"Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men","volume":"24","author":"Nilsson","year":"2013","journal-title":"Osteoporos Int"},{"issue":"4","key":"2024021014332336400_jbmr3428-bib-0004","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1359\/jbmr.071203","article-title":"BMD decreases over the course of a year in competitive male cyclists","volume":"23","author":"Barry","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2024021014332336400_jbmr3428-bib-0005","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/jama.1996.03540030060033","article-title":"Changes in bone mineral content in male athletes. Mechanisms of action and intervention effects","volume":"276","author":"Klesges","year":"1996","journal-title":"JAMA"},{"issue":"6","key":"2024021014332336400_jbmr3428-bib-0006","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00223-007-9028-y","article-title":"Acute effects of 2 hours of moderate-intensity cycling on serum parathyroid hormone and calcium","volume":"80","author":"Barry","year":"2007","journal-title":"Calcif Tissue Int"},{"issue":"10","key":"2024021014332336400_jbmr3428-bib-0007","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1249\/MSS.0000000000000320","article-title":"Calcium supplementation and parathyroid hormone response to vigorous walking in postmenopausal women","volume":"46","author":"Shea","year":"2014","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"2024021014332336400_jbmr3428-bib-0008","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1249\/MSS.0000000000001239","article-title":"Calcium supplementation attenuates disruptions in calcium homeostasis during exercise","volume":"49","author":"Sherk","year":"2017","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"2024021014332336400_jbmr3428-bib-0009","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1249\/MSS.0b013e3181f79fa8","article-title":"Acute calcium ingestion attenuates exercise-induced disruption of calcium homeostasis","volume":"43","author":"Barry","year":"2011","journal-title":"Med Sci Sports Exerc"},{"issue":"8","key":"2024021014332336400_jbmr3428-bib-0010","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1210\/jc.2009-2516","article-title":"The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running","volume":"95","author":"Scott","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024021014332336400_jbmr3428-bib-0011","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1152\/japplphysiol.00764.2010","article-title":"The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise","volume":"110","author":"Scott","year":"2011","journal-title":"J Appl Physiol"},{"issue":"3","key":"2024021014332336400_jbmr3428-bib-0012","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1249\/MSS.0b013e3182746e28","article-title":"Effect of recovery duration between two bouts of running on bone metabolism","volume":"45","author":"Scott","year":"2013","journal-title":"Med Sci Sports Exerc"},{"issue":"5)","key":"2024021014332336400_jbmr3428-bib-0013","first-page":"0123302","article-title":"The effects of a calcium-rich pre-exercise meal on biomarkers of calcium homeostasis in competitive female cyclists: a randomised crossover trial","volume":"10","author":"Haakonssen","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"2024021014332336400_jbmr3428-bib-0014","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00223-003-0070-0","article-title":"Acute effects of an oral calcium load on markers of bone metabolism during endurance cycling exercise in male athletes","volume":"74","author":"Guillemant","year":"2004","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2024021014332336400_jbmr3428-bib-0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","article-title":"A new predictive equation for resting energy expenditure in healthy individuals","volume":"51","author":"Mifflin","year":"1990","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2024021014332336400_jbmr3428-bib-0016","first-page":"367","article-title":"Parathyroid hormone and physical exercise: a brief review","volume":"5","author":"Bouassida","year":"2006","journal-title":"J Sports Sci Med"},{"issue":"6","key":"2024021014332336400_jbmr3428-bib-0017","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2362.1984.tb01215.x","article-title":"Effects of physical exercise on serum calcium and parathyroid hormone","volume":"14","author":"Ljunghall","year":"1984","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"2024021014332336400_jbmr3428-bib-0018","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2265.1986.tb03606.x","article-title":"Prolonged low-intensity exercise raises the serum parathyroid hormone levels","volume":"25","author":"Ljunghall","year":"1986","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2024021014332336400_jbmr3428-bib-0019","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1249\/00005768-198820020-00004","article-title":"Increase in serum parathyroid hormone levels after prolonged physical exercise","volume":"20","author":"Ljunghall","year":"1988","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"2024021014332336400_jbmr3428-bib-0020","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/BF00295947","article-title":"Intact serum parathyroid hormone levels increase during running exercise in well-trained men","volume":"54","author":"Salvesen","year":"1994","journal-title":"Calcif Tissue Int"},{"issue":"8","key":"2024021014332336400_jbmr3428-bib-0021","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1210\/jc.2016-1848","article-title":"Parathyroid hormone secretion is controlled by both ionized calcium and phosphate during exercise and recovery in men","volume":"101","author":"Townsend","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024021014332336400_jbmr3428-bib-0022","doi-asserted-by":"crossref","first-page":"E780","DOI":"10.1152\/ajpendo.00473.2003","article-title":"Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog","volume":"286","author":"L\u00f3pez","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"2024021014332336400_jbmr3428-bib-0023","first-page":"4236","article-title":"Control of pulsatile and tonic parathyroid hormone secretion by ionized calcium","volume":"81","author":"Schmitt","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024021014332336400_jbmr3428-bib-0024","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2362.1985.tb00178.x","article-title":"Regional and systemic effects of short-term intense muscular work on plasma concentration and content of total and ionized calcium","volume":"15","author":"Ljunghall","year":"1985","journal-title":"Eur J Clin Invest"},{"issue":"5884","key":"2024021014332336400_jbmr3428-bib-0025","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/299658a0","article-title":"Reduction in plasma calcium during exercise in man","volume":"299","author":"Convertino","year":"1982","journal-title":"Nature"},{"issue":"4\u20135","key":"2024021014332336400_jbmr3428-bib-0026","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00421-002-0721-2","article-title":"Parathyroid hormone concentrations during and after two periods of high intensity exercise with and without an intervening recovery period","volume":"88","author":"Bouassida","year":"2003","journal-title":"Eur J Appl Physiol"},{"issue":"8","key":"2024021014332336400_jbmr3428-bib-0027","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s00198-015-3203-1","article-title":"The calcium-sensing receptor in bone metabolism: from bench to bedside and back","volume":"26","author":"Cianferotti","year":"2015","journal-title":"Osteoporos Int"},{"key":"2024021014332336400_jbmr3428-bib-0028","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.matbio.2016.02.010","article-title":"PTH signaling mediates perilacunar remodeling during exercise","volume":"52\u201354","author":"Gardinier","year":"2016","journal-title":"Matrix Biol"},{"issue":"1","key":"2024021014332336400_jbmr3428-bib-0029","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1475-097X.1990.tb00082.x","article-title":"Effects of prolonged adrenaline infusion and of mental stress on plasma minerals and parathyroid hormone","volume":"10","author":"Joborn","year":"1990","journal-title":"Clin Physiol"},{"issue":"9","key":"2024021014332336400_jbmr3428-bib-0030","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1359\/jbmr.2002.17.9.1691","article-title":"Direct effect of acute metabolic and respiratory acidosis on parathyroid hormone secretion in the dog","volume":"17","author":"Lopez","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024021014332336400_jbmr3428-bib-0031","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S8756-3282(01)00662-7","article-title":"Mechanism of circadian variation in bone resorption","volume":"30","author":"Bjarnason","year":"2002","journal-title":"Bone"},{"issue":"10","key":"2024021014332336400_jbmr3428-bib-0032","first-page":"801","article-title":"Catabolic and anabolic actions of parathyroid hormone on the skeleton","volume":"34","author":"Silva","year":"2011","journal-title":"J Endocrinol Invest"},{"issue":"7","key":"2024021014332336400_jbmr3428-bib-0033","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2003-1703","article-title":"Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy","volume":"90","author":"Dobnig","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2024021014332336400_jbmr3428-bib-0034","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"JAMA"},{"issue":"3","key":"2024021014332336400_jbmr3428-bib-0035","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S8756-3282(03)00202-3","article-title":"Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure","volume":"33","author":"Frolik","year":"2003","journal-title":"Bone"},{"issue":"1","key":"2024021014332336400_jbmr3428-bib-0036","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00198-012-2159-7","article-title":"Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women","volume":"24","author":"Shiraki","year":"2013","journal-title":"Osteoporos Int"},{"key":"2024021014332336400_jbmr3428-bib-0037","first-page":"7","article-title":"Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: a pilot study","volume":"5","author":"Almirol","year":"2016","journal-title":"J Clin Transl Endocrinol"},{"issue":"6","key":"2024021014332336400_jbmr3428-bib-0038","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/jbmr.2432","article-title":"PTH signaling during exercise contributes to bone adaptation","volume":"30","author":"Gardinier","year":"2015","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/7\/1326\/56651092\/jbmr3428.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/7\/1326\/56651092\/jbmr3428.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:01:35Z","timestamp":1710342095000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/33\/7\/1326-1334\/7605412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,3,23]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3428","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7,1]]},"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2017-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}