{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:12:40Z","timestamp":1788973960747,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR061445"],"award-info":[{"award-number":["R01AR061445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Weight loss in older adults is associated with increased bone loss and fracture. Little is known about the potential impact of weight loss on cortical and trabecular bone density, microarchitecture, and strength. In this study, participants were members of the Framingham Offspring Cohort (769 women, 595 men; mean age 70\u2009\u00b1\u20098 years), who underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) scanning at the tibia and radius in 2012 to 2016. Weight measurements taken every 4 to 6 years were used to assess recent weight change over 6 years and long-term change over 40 years. General linear models, adjusting for age, sex, height, smoking, and diabetes, were used to evaluate the association between HR-pQCT indices and relative long-term and recent weight change. We found that long-term and recent weight loss were associated with lower cortical density and thickness, higher cortical porosity, and lower trabecular density and number. Associations were stronger for the tibia than radius. Failure load was lower in those individuals with long-term but not short-term weight loss. Deterioration in both cortical and trabecular indices, especially at the weight-bearing skeleton, characterizes bone fragility associated with long-term and recent weight loss in older adults. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3472","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T20:49:25Z","timestamp":1527626965000},"page":"1851-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Long-Term and Recent Weight Change Are Associated With Reduced Peripheral Bone Density, Deficits in Bone Microarchitecture, and Decreased Bone Strength: The Framingham Osteoporosis Study"],"prefix":"10.1093","volume":"33","author":[{"given":"Ching-Ti","family":"Liu","sequence":"first","affiliation":[{"name":"Department of BiostatisticsBoston University School of Public HealthBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of General MedicineBeth Israel Deaconess Medical CenterBostonMAUSA"},{"name":"Department of MedicineHarvard Medical SchoolBostonMAUSA"},{"name":"Institute for Aging ResearchHebrew SeniorLifeBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of BiostatisticsBoston University School of Public HealthBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of General MedicineBeth Israel Deaconess Medical CenterBostonMAUSA"},{"name":"Department of MedicineHarvard Medical SchoolBostonMAUSA"},{"name":"Institute for Aging ResearchHebrew SeniorLifeBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry E","family":"Broe","sequence":"additional","affiliation":[{"name":"Institute for Aging ResearchHebrew SeniorLifeBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian T","family":"Hannan","sequence":"additional","affiliation":[{"name":"Department of General MedicineBeth Israel Deaconess Medical CenterBostonMAUSA"},{"name":"Department of MedicineHarvard Medical SchoolBostonMAUSA"},{"name":"Institute for Aging ResearchHebrew SeniorLifeBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K","family":"Boyd","sequence":"additional","affiliation":[{"name":"McCraig Institute for Bone and Joint HealthCumming School of MedicineUniversity of CalgaryCalgaryCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Bouxsein","sequence":"additional","affiliation":[{"name":"Department of Orthopedic SurgeryHarvard 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