{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:00Z","timestamp":1792000500683,"version":"4.4.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. We performed systematic bone and mineral evaluations of subjects with cystinosis seen at the NIH (n\u2009=\u200930), including history and physical examination, serum and urine biochemistries, DXA, vertebral fracture assessment, skeletal radiographs, and renal ultrasound. Additionally, histomorphometric analyses are reported on six subjects seen at the UCLA Bone and Mineral Metabolism Clinic. In NIH subjects, mean age was 20 years (range, 5 to 44 years), 60% were CKD stages G1 to G4, and 40% had a renal transplant. Mean bone mineral density (BMD) Z-scores were decreased in the femoral neck, total hip, and 1\/3 radius (p\u2009&amp;lt;\u20090.05). Low bone mass at one or more sites was present in 46% of subjects. Twenty-seven percent of subjects reported one or more long bone fractures. Thirty-two percent of subjects had incidental vertebral fractures, which were unrelated to transplant status. Long-bone deformity\/bowing was present in 64%; 50% had scoliosis. Diffuse osteosclerosis was present in 21% of evaluated subjects. Risk factors included CKD, phosphate wasting, hypercalciuria, secondary hyperparathyroidism, hypovitaminosis D, male hypogonadism, metabolic acidosis, and glucocorticoid\/immunosuppressive therapy. Sixty-one percent of the non-transplanted subjects had ultrasonographic evidence of nephrocalcinosis or nephrolithiasis. Histomorphometric analyses showed impaired mineralization in four of six studied subjects. We conclude that skeletal deformities, decreased bone mass, and vertebral fractures are common and relevant complications of nephropathic cystinosis, even before renal transplantation. Efforts to minimize risk factors for skeletal disease include optimizing mineral metabolism and hormonal status, combined with monitoring for nephrocalcinosis\/nephrolithiasis. \u00a9 2018 This article is a U.S. Government work and is in the public domain in the USA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3522","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T17:24:58Z","timestamp":1529083498000},"page":"1870-1880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Skeletal Consequences of Nephropathic Cystinosis"],"prefix":"10.1093","volume":"33","author":[{"given":"Pablo","family":"Florenzano","sequence":"first","affiliation":[{"name":"Endocrinology DepartmentSchool of MedicinePontificia Universidad Catolica de ChileSantiagoChile"},{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Medical Genetics BranchNational Human Genome Research Institute (NHGRI)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Nesterova","sequence":"additional","affiliation":[{"name":"Medical Genetics BranchNational Human Genome Research Institute (NHGRI)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Scott","family":"Roberts","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Harsha","family":"Tella","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernandez","family":"de Castro","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney M","family":"Brown","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adom","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata C","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of NephrologyDepartment of PediatricsDavid Geffen School of Medicine, University of CaliforniaLos Angeles (UCLA)Los AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Bulas","sequence":"additional","affiliation":[{"name":"Division of RadiologyChildren's National Health SystemWashingtonDCUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel I","family":"Gafni","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro B","family":"Salusky","sequence":"additional","affiliation":[{"name":"Division of NephrologyDepartment of PediatricsDavid Geffen School of Medicine, University of CaliforniaLos Angeles (UCLA)Los AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Gahl","sequence":"additional","affiliation":[{"name":"Medical Genetics BranchNational Human Genome Research Institute (NHGRI)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Collins","sequence":"additional","affiliation":[{"name":"Section on Skeletal Disorders and Mineral HomeostasisNational Institutes of Dental and Craniofacial Research (NIDCR)National Institutes of Health (NIH)BethesdaMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"issue":"Suppl 4","key":"2024021014294079400_jbmr3522-bib-0001","doi-asserted-by":"crossref","first-page":"iv87","DOI":"10.1093\/ndt\/gfu090","article-title":"Nephropathic cystinosis: an international consensus document","volume":"29","author":"Emma","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"2024021014294079400_jbmr3522-bib-0002","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13023-016-0426-y","article-title":"Cystinosis: a review","volume":"11","author":"Elmonem","year":"2016","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"2024021014294079400_jbmr3522-bib-0003","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7326\/0003-4819-147-4-200708210-00006","article-title":"Nephropathic cystinosis in adults: natural history and effects of oral cysteamine therapy","volume":"147","author":"Gahl","year":"2007","journal-title":"Ann Intern Med"},{"issue":"6","key":"2024021014294079400_jbmr3522-bib-0004","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00467-007-0650-8","article-title":"Nephropathic cystinosis: late complications of a multisystemic disease","volume":"23","author":"Nesterova","year":"2008","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"2024021014294079400_jbmr3522-bib-0005","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1086\/302118","article-title":"CTNS mutations in an American-based population of cystinosis patients","volume":"63","author":"Shotelersuk","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0006","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMra020552","volume":"347","author":"Gahl","year":"2002","journal-title":"Cystinosis. N Engl J Med"},{"key":"2024021014294079400_jbmr3522-bib-0007","author":"Nesterova","year":"2001"},{"issue":"11","key":"2024021014294079400_jbmr3522-bib-0008","first-page":"3257","article-title":"Effects of early cysteamine therapy on thyroid function and growth in nephropathic cystinosis","volume":"80","author":"Kimonis","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2024021014294079400_jbmr3522-bib-0009","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1007\/s00431-003-1349-x","article-title":"Early oral cysteamine therapy for nephropathic cystinosis","volume":"162","author":"Gahl","year":"2003","journal-title":"Eur J Pediatr"},{"key":"2024021014294079400_jbmr3522-bib-0010","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jpeds.2016.12.052","article-title":"Bone complications of cystinosis","volume":"183S","author":"Langman","year":"2017","journal-title":"J Pediatr"},{"issue":"4","key":"2024021014294079400_jbmr3522-bib-0011","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00467-003-1093-5","article-title":"Osteopenia and fractures in cystinotic children post renal transplantation","volume":"18","author":"Zimakas","year":"2003","journal-title":"Pediatr Nephrol"},{"key":"2024021014294079400_jbmr3522-bib-0012","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12967-015-0494-0","article-title":"Cysteamine treatment restores the in vitro ability to differentiate along the osteoblastic lineage of mesenchymal stromal cells isolated from bone marrow of a cystinotic patient","volume":"13","author":"Conforti","year":"2015","journal-title":"J Transl Med"},{"key":"2024021014294079400_jbmr3522-bib-0013","article-title":"Bone disease in nephropathic cystinosis is related to cystinosin-induced osteoclastic dysfunction","author":"Claramunt-Taberner","journal-title":"Nephrol Dial Transplant"},{"key":"2024021014294079400_jbmr3522-bib-0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/8904_2013_256","article-title":"Cystinosis with sclerotic bone lesions","volume":"13","author":"Sirrs","year":"2014","journal-title":"JIMD Rep"},{"key":"2024021014294079400_jbmr3522-bib-0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00256-013-1735-z","article-title":"Progressive destructive bone changes in patients with cystinosis","volume":"43","author":"Klusmann","year":"2014","journal-title":"Skeletal Radiol"},{"issue":"7","key":"2024021014294079400_jbmr3522-bib-0016","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00467-018-3902-x","article-title":"Teenagers and young adults with nephropathic cystinosis display significant bone disease and cortical impairment","volume":"33","author":"Bertholet-Thomas","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"2024021014294079400_jbmr3522-bib-0017","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/bonekey.2016.55","article-title":"Skeletal implications and management of cystinosis: three case reports and literature review","volume":"5","author":"Bacchetta","year":"2016","journal-title":"Bonekey Rep"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0018","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/jc.2006-1706","article-title":"Sex- and age-specific reference curves for serum markers of bone turnover in healthy children from 2 months to 18 years","volume":"92","author":"Rauchenzauner","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2024021014294079400_jbmr3522-bib-0019","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024021014294079400_jbmr3522-bib-0020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00247-013-2837-4","article-title":"Observer agreement in pediatric semiquantitative vertebral fracture diagnosis","volume":"44","author":"Siminoski","year":"2014","journal-title":"Pediatr Radiol"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0021","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jocd.2014.01.007","article-title":"Zemel BS; International Society for Clinical Densitometry. 2013 Pediatric Position Development Conference: executive summary and reflections","volume":"17","author":"Gordon","year":"2014","journal-title":"J Clin Densitom"},{"issue":"10","key":"2024021014294079400_jbmr3522-bib-0022","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1210\/jc.2011-1111","article-title":"Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study","volume":"96","author":"Zemel","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024021014294079400_jbmr3522-bib-0023","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1359\/jbmr.1998.13.12.1915","article-title":"Bone density and fracture risk in men","volume":"13","author":"Melton","year":"1998","journal-title":"J Bone Miner Res"},{"issue":"Suppl 3","key":"2024021014294079400_jbmr3522-bib-0024","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.2215\/CJN.00460107","article-title":"Technical approach to iliac crest biopsy","volume":"3","author":"Hernandez","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"2024021014294079400_jbmr3522-bib-0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024021014294079400_jbmr3522-bib-0026","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1046\/j.1523-1755.1998.00866.x","article-title":"Bone disease in children and adolescents undergoing successful renal transplantation","volume":"53","author":"Sanchez","year":"1998","journal-title":"Kidney Int"},{"issue":"11","key":"2024021014294079400_jbmr3522-bib-0027","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0028","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S8756-3282(99)00257-4","article-title":"Normative data for iliac bone histomorphometry in growing children","volume":"26","author":"Glorieux","year":"2000","journal-title":"Bone"},{"key":"2024021014294079400_jbmr3522-bib-0029","first-page":"5","year":"2013"},{"key":"2024021014294079400_jbmr3522-bib-0030","article-title":"Effects of long-term cysteamine treatment in patients with cystinosis","author":"Ariceta","year":"2017","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"2024021014294079400_jbmr3522-bib-0031","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s00198-016-3648-x","article-title":"Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis","volume":"27","author":"Al-Sari","year":"2016","journal-title":"Osteoporos Int"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0032","doi-asserted-by":"crossref","first-page":"221.e1","DOI":"10.1016\/j.amjmed.2015.09.020","article-title":"Vertebral fractures: clinical importance and management","volume":"129","author":"Kendler","year":"2016","journal-title":"Am J Med"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0033","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01202412-199704000-00002","article-title":"Epidemiology of children's fractures","volume":"6","author":"Landin","year":"1997","journal-title":"J Pediatr Orthop B"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0034","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-010-9373-0","article-title":"Phenotype presentation of hypophosphatemic rickets in adults","volume":"87","author":"Beck-Nielsen","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"2024021014294079400_jbmr3522-bib-0035","doi-asserted-by":"crossref","first-page":"17101","DOI":"10.1038\/nrdp.2017.101","article-title":"Rickets","volume":"3","author":"Carpenter","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2024021014294079400_jbmr3522-bib-0036","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1530\/EJE-15-0661","article-title":"Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms","volume":"174","author":"Che","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2024021014294079400_jbmr3522-bib-0037","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1359\/jbmr.070319","article-title":"Exclusion of focal vertebral artifacts from spine bone densitometry and fracture prediction: a comparison of expert physicians, three computer algorithms, and the minimum vertebra","volume":"22","author":"Tsang","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2024021014294079400_jbmr3522-bib-0038","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/pr.2017.117","article-title":"Bone mineral density in patients with inherited bone marrow failure syndromes","volume":"82","author":"Shankar","year":"2017","journal-title":"Pediatr Res"},{"issue":"4","key":"2024021014294079400_jbmr3522-bib-0039","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00866713","article-title":"Medullary nephrocalcinosis in nephropathic cystinosis","volume":"9","author":"Theodoropoulos","year":"1995","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"2024021014294079400_jbmr3522-bib-0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.semnephrol.2008.01.006","article-title":"Bone disease and idiopathic hypercalciuria","volume":"28","author":"Zerwekh","year":"2008","journal-title":"Semin Nephrol"},{"issue":"1\u20132","key":"2024021014294079400_jbmr3522-bib-0041","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000365089","article-title":"Association of serum bicarbonate with bone fractures in hemodialysis patients: the mineral and bone disorder outcomes study for Japanese CKD stage 5D patients (MBD-5D)","volume":"128","author":"Kato","year":"2014","journal-title":"Nephron Clin Pract"},{"issue":"5","key":"2024021014294079400_jbmr3522-bib-0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/j.ackd.2017.06.005","article-title":"Adverse effects of the metabolic acidosis of chronic kidney disease","volume":"24","author":"Kraut","year":"2017","journal-title":"Adv Chronic Kidney Dis"},{"issue":"3","key":"2024021014294079400_jbmr3522-bib-0043","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000087537","article-title":"Distal renal tubular acidosis: alkali heals osteomalacia and increases net production of 1,25-dihydroxyvitamin D","volume":"101","author":"Wrong","year":"2005","journal-title":"Nephron Physiol"},{"issue":"6","key":"2024021014294079400_jbmr3522-bib-0044","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.med.0000436185.36717.76","article-title":"Male hypogonadism and skeletal health","volume":"20","author":"Irwig","year":"2013","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"12","key":"2024021014294079400_jbmr3522-bib-0045","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1007\/s00198-014-2823-1","article-title":"Vitamin D insufficiency over 5 years is associated with increased fracture risk-an observational cohort study of elderly women","volume":"25","author":"Buchebner","year":"2014","journal-title":"Osteoporos Int"},{"issue":"5","key":"2024021014294079400_jbmr3522-bib-0046","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s00223-014-9842-y","article-title":"A meta-analysis of reference markers of bone turnover for prediction of fracture","volume":"94","author":"Johansson","year":"2014","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"2024021014294079400_jbmr3522-bib-0047","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1681\/ASN.2005111194","article-title":"Relationship between moderate to severe kidney disease and hip fracture in the United States","volume":"17","author":"Nickolas","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"2024021014294079400_jbmr3522-bib-0048","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00223-017-0335-7","article-title":"Glucocorticoids, inflammation and bone","volume":"102","author":"Guler-Yuksel","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"9","key":"2024021014294079400_jbmr3522-bib-0049","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.transproceed.2017.07.005","article-title":"Effects of cyclosporine, tacrolimus, and rapamycin on osteoblasts","volume":"49","author":"Martin-Fernandez","year":"2017","journal-title":"Transplant Proc"},{"issue":"12","key":"2024021014294079400_jbmr3522-bib-0050","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1097\/TP.0b013e3181a6bbda","article-title":"Risk of fractures after renal transplantation in the United States","volume":"87","author":"Nikkel","year":"2009","journal-title":"Transplantation"},{"issue":"12","key":"2024021014294079400_jbmr3522-bib-0051","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/TP.0b013e31828eead8","article-title":"Fracture risk in kidney transplant recipients: a systematic review","volume":"95","author":"Naylor","year":"2013","journal-title":"Transplantation"},{"issue":"3","key":"2024021014294079400_jbmr3522-bib-0052","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jpeds.2013.03.078","article-title":"Copper deficiency in patients with cystinosis with cysteamine toxicity","volume":"163","author":"Besouw","year":"2013","journal-title":"J Pediatr"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/10\/1870\/56649139\/jbmr3522.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/10\/1870\/56649139\/jbmr3522.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:02:15Z","timestamp":1710342135000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/33\/10\/1870-1880\/7605138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,6,15]]},"published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3522","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10,1]]},"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"2018-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}