{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:35:06Z","timestamp":1792154106594,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release that is associated with severe, highly penetrant, repetitive, and perseverative movements commonly found in human autism spectrum disorder patients. However, no known function of Cntnap4 has been revealed besides the nervous system. Meanwhile, secretory protein neural EGFL-like 1 (Nell-1) is known to exert potent osteogenic effects in multiple small and large animal models without the off-target effects commonly found with bone morphogenetic protein 2. In this study, while searching for a Nell-1-specific cell surface receptor during osteogenesis, we identified and validated a ligand\/receptor-like interaction between Nell-1 and Cntnap4 by demonstrating: 1) Nell-1 and Cntnap4 colocalization on the surface of osteogenic-committed cells; 2) high-affinity interaction between Nell-1 and Cntnap4; 3) abrogation of Nell-1-responsive Wnt and MAPK signaling transduction, as well as osteogenic effects, via Cntnap4 knockdown; and 4) replication of calvarial cleidocranial dysplasias-like defects observed in Nell-1-deficient mice in Wnt1-Cre-mediated Cntnap4-knockout transgenic mice. In aggregate, these findings indicate that Cntnap4 plays a critical role in Nell-1-responsive osteogenesis. Further, this is the first functional annotation for Cntnap4 in the musculoskeletal system. Intriguingly, Nell-1 and Cntnap4 also colocalize on the surface of human hippocampal interneurons, implicating Nell-1 as a potential novel ligand for Cntnap4 in the nervous system. This unexpected characterization of the ligand\/receptor-like interaction between Nell-1 and Cntnap4 indicates a novel biological functional axis for Nell-1 and Cntnap4 in osteogenesis and, potentially, in neural development and function. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3524","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T17:26:58Z","timestamp":1529083618000},"page":"1813-1825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis"],"prefix":"10.1093","volume":"33","author":[{"given":"Chenshuang","family":"Li","sequence":"first","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Stomatology, College of MedicineZhejiang UniversityHangzhouZhejiangPR China"},{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and BiotechnologyState Key Laboratory of Biomembrane and Membrane BiotechnologyTsinghua UniversityBeijingPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"School and Hospital of StomatologyPeking UniversityBeijingPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Asatrian","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A","family":"Berthiaume","sequence":"additional","affiliation":[{"name":"David Geffen School of MedicineUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Kil","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Ting","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research CenterUniversity of California, Los AngelesLos AngelesCAUSA"},{"name":"Division of Growth and Development, Section of Orthodontics, School of DentistryUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia","family":"Soo","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research CenterUniversity of California, Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"issue":"9","key":"2024021014294448500_jbmr3524-bib-0001","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/0022034510376401","article-title":"The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration","volume":"89","author":"Zhang","year":"2010","journal-title":"J Dent Res"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.1638","article-title":"Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2","volume":"265","author":"Kuroda","year":"1999","journal-title":"Biochem Biophys Research Commun"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0003","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1359\/jbmr.1999.14.1.80","article-title":"Human NELL-1 expressed in unilateral coronal synostosis","volume":"14","author":"Ting","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"1263","key":"2024021014294448500_jbmr3524-bib-0004","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1098\/rstb.1991.0045","article-title":"The structure and function of protein modules","volume":"332","author":"Campbell","year":"1991","journal-title":"Philos T Roy Soc B"},{"issue":"1-2","key":"2024021014294448500_jbmr3524-bib-0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0378-1119(01)00827-7","article-title":"Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems","volume":"287","author":"Abreu","year":"2002","journal-title":"Gene"},{"issue":"6","key":"2024021014294448500_jbmr3524-bib-0006","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1172\/JCI15375","article-title":"Craniosynostosis in transgenic mice overexpressing Nell-1","volume":"110","author":"Zhang","year":"2002","journal-title":"J Clin Invest"},{"issue":"3","key":"2024021014294448500_jbmr3524-bib-0007","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/geno.1996.0628","article-title":"Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats","volume":"38","author":"Watanabe","year":"1996","journal-title":"Genomics"},{"issue":"12","key":"2024021014294448500_jbmr3524-bib-0008","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1359\/jbmr.2003.18.12.2126","article-title":"Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development","volume":"18","author":"Zhang","year":"2003","journal-title":"J Bone Miner Res"},{"issue":"8","key":"2024021014294448500_jbmr3524-bib-0009","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/hmg\/ddl053","article-title":"Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects","volume":"15","author":"Desai","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1359\/jbmr.061012","article-title":"Craniosynostosis-associated gene nell-1 is regulated by runx2","volume":"22","author":"Truong","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0011","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/SCS.0b013e318240c8c4","article-title":"Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency","volume":"23","author":"Zhang","year":"2012","journal-title":"J Craniofac Surg"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0012","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajmg.a.37978","article-title":"Identification of 11p14.1-p15.3 deletion probably associated with short stature, relative macrocephaly, and delayed closure of the fontanelles","volume":"173","author":"Dateki","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"3","key":"2024021014294448500_jbmr3524-bib-0013","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2353\/ajpath.2006.051210","article-title":"Nell-1-induced bone regeneration in calvarial defects","volume":"169","author":"Aghaloo","year":"2006","journal-title":"Am J Pathol"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0014","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/PRS.0b013e3181fed5ae","article-title":"Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model","volume":"127","author":"Li","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"7-8","key":"2024021014294448500_jbmr3524-bib-0015","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1089\/ten.tea.2010.0486","article-title":"Nell-1 protein promotes bone formation in a sheep spinal fusion model","volume":"17","author":"Siu","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"2024021014294448500_jbmr3524-bib-0016","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1038\/ncomms8362","article-title":"NELL-1 in the treatment of osteoporotic bone loss","volume":"6","author":"James","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0017","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbrc.2011.06.111","article-title":"A new function of Nell-1 protein in repressing adipogenic differentiation","volume":"411","author":"James","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2024021014294448500_jbmr3524-bib-0018","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bone.2010.10.166","article-title":"NELL1 promotes high-quality bone regeneration in rat femoral distraction osteogenesis model","volume":"48","author":"Xue","year":"2011","journal-title":"Bone"},{"issue":"21-22","key":"2024021014294448500_jbmr3524-bib-0019","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1089\/ten.tea.2012.0519","article-title":"BMP2-induced inflammation can be suppressed by the osteoinductive growth factor NELL-1","volume":"19","author":"Shen","year":"2013","journal-title":"Tissue Eng Part A"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ajpath.2015.10.011","article-title":"Novel Wnt regulator NEL-like molecule-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2","volume":"186","author":"Shen","year":"2016","journal-title":"Am J Pathol"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0021","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/mcne.2002.1110","article-title":"Caspr3 and caspr4, two novel members of the caspr family, are expressed in the nervous system and interact with PDZ domains","volume":"20","author":"Spiegel","year":"2002","journal-title":"Mol Cell Neurosci"},{"issue":"7508","key":"2024021014294448500_jbmr3524-bib-0022","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature13248","article-title":"Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission","volume":"511","author":"Karayannis","year":"2014","journal-title":"Nature"},{"issue":"5","key":"2024021014294448500_jbmr3524-bib-0023","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1089\/scd.2014.0261","article-title":"Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells","volume":"24","author":"Yin","year":"2015","journal-title":"Stem Cells Dev"},{"key":"2024021014294448500_jbmr3524-bib-0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-62703-640-5_1","article-title":"General overview of neuronal cell culture","volume":"1078","author":"Gordon","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"3","key":"2024021014294448500_jbmr3524-bib-0025","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat Protoc"},{"issue":"9","key":"2024021014294448500_jbmr3524-bib-0026","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.4103\/1673-5374.215268","article-title":"Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases","volume":"12","author":"Zou","year":"2017","journal-title":"Neural Regen Res"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0027","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bone.2005.06.023","article-title":"Nell-1 induced bone formation within the distracted intermaxillary suture","volume":"38","author":"Cowan","year":"2006","journal-title":"Bone"},{"issue":"4","key":"2024021014294448500_jbmr3524-bib-0028","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/jbmr.267","article-title":"Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+\/-) mice","volume":"26","author":"Zhang","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2024021014294448500_jbmr3524-bib-0029","volume-title":"Guiding osteogenic lineage commitment: the role of mesenchymal stem cell biology and the mechanical microenvironment","author":"Arnsdorf","year":"2008"},{"key":"2024021014294448500_jbmr3524-bib-0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-2867-10-42","article-title":"Determination of the differentiation capacities of murines\u2019 primary mononucleated cells and MC3T3-E1 cells","volume":"10","author":"Yazid","year":"2010","journal-title":"Cancer Cell Int"},{"issue":"8","key":"2024021014294448500_jbmr3524-bib-0031","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/labinvest.2011.72","article-title":"Functional characterization of osteosarcoma cell lines provides representative models to study the human disease","volume":"91","author":"Mohseny","year":"2011","journal-title":"Lab Invest"},{"issue":"2)","key":"2024021014294448500_jbmr3524-bib-0032","doi-asserted-by":"crossref","first-page":"31200","DOI":"10.1371\/journal.pone.0031200","article-title":"MG63 osteoblast-like cells exhibit different behavior when grown on electrospun collagen matrix versus electrospun gelatin matrix","volume":"7","author":"Tsai","year":"2012","journal-title":"PloS One"},{"issue":"5","key":"2024021014294448500_jbmr3524-bib-0033","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jor.21585","article-title":"Effect of 25-hydroxyvitamin D3 and 1 alpha,25 dihydroxyvitamin D-3 on differentiation and apoptosis of human osteosarcoma cell lines","volume":"30","author":"Thompson","year":"2012","journal-title":"J Orthop Res"},{"issue":"4","key":"2024021014294448500_jbmr3524-bib-0034","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0092-8674(79)90317-9","article-title":"Multiple new phenotypes induced in 10t1\/2-cells and 3t3-cells treated with 5-azacytidine","volume":"17","author":"Taylor","year":"1979","journal-title":"Cell"},{"issue":"5","key":"2024021014294448500_jbmr3524-bib-0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clbc.2015.01.004","article-title":"Phenotypic and functional characterization of ductal carcinoma in situ-associated myoepithelial cells","volume":"15","author":"Rohilla","year":"2015","journal-title":"Clin Breast Cancer"},{"issue":"6","key":"2024021014294448500_jbmr3524-bib-0036","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jcb.24467","article-title":"ATDC5: an excellent in vitro model cell line for skeletal development","volume":"114","author":"Yao","year":"2013","journal-title":"J Cell Biochem"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0037","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/ABAB:126:2:079","article-title":"Surface plasmon resonance: applications in understanding receptor-ligand interaction","volume":"126","author":"Pattnaik","year":"2005","journal-title":"Appl Biochem Biotechnol"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0038","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.febslet.2007.12.006","article-title":"Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation","volume":"582","author":"Bokui","year":"2008","journal-title":"FEBS Lett"},{"issue":"10","key":"2024021014294448500_jbmr3524-bib-0039","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1007\/s00264-012-1590-x","article-title":"NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation","volume":"36","author":"Chen","year":"2012","journal-title":"Int Orthop"},{"issue":"4","key":"2024021014294448500_jbmr3524-bib-0040","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbrc.2015.03.127","article-title":"Apoptosis related protein 3 is a lysosomal membrane protein","volume":"460","author":"Ding","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2024021014294448500_jbmr3524-bib-0041","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/labinvest.3700430","article-title":"Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development","volume":"86","author":"Zhang","year":"2006","journal-title":"Lab Invest"},{"issue":"5","key":"2024021014294448500_jbmr3524-bib-0042","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"issue":"16","key":"2024021014294448500_jbmr3524-bib-0043","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1016\/j.febslet.2012.06.014","article-title":"The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1","volume":"586","author":"Hasebe","year":"2012","journal-title":"FEBS Lett"},{"issue":"6","key":"2024021014294448500_jbmr3524-bib-0044","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jbmr.314","article-title":"Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells","volume":"26","author":"Chen","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024021014294448500_jbmr3524-bib-0045","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1074\/jbc.M111.281485","article-title":"Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions","volume":"287","author":"Nakamura","year":"2012","journal-title":"J Biol Chem"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0046","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1467-8624.2012.01838.x","article-title":"A genome-wide association study of autism incorporating autism diagnostic interview-revised, autism diagnostic observation schedule, and social responsiveness scale","volume":"84","author":"Connolly","year":"2013","journal-title":"Child Dev"},{"issue":"3","key":"2024021014294448500_jbmr3524-bib-0047","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.3390\/ijms16036464","article-title":"High-resolution chromosome ideogram representation of currently recognized genes for autism spectrum disorders","volume":"16","author":"Butler","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0048","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.4238\/2015.June.29.15","article-title":"Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis","volume":"14","author":"Zhang","year":"2015","journal-title":"Genet Mol Res"},{"issue":"1","key":"2024021014294448500_jbmr3524-bib-0049","first-page":"13","article-title":"Crosstalk between the brain and bone","volume":"9","author":"Masi","year":"2012","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0050","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11154-015-9312-5","article-title":"Bone, brain & beyond","volume":"16","author":"Chamouni","year":"2015","journal-title":"Rev Endocr Metab Dis"},{"issue":"7381","key":"2024021014294448500_jbmr3524-bib-0051","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature10763","article-title":"The contribution of bone to whole-organism physiology","volume":"481","author":"Karsenty","year":"2012","journal-title":"Nature"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0052","first-page":"69","article-title":"Bone-brain crosstalk and potential associated diseases","volume":"28","author":"Rousseaud","year":"2016","journal-title":"Horm Mol Biol Clin I"},{"issue":"2","key":"2024021014294448500_jbmr3524-bib-0053","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pdj.2016.04.001","article-title":"Cleidocranial dysplasia: clinical overview and genetic considerations","volume":"26","author":"Hassan","year":"2016","journal-title":"Pediatr Dent J"},{"issue":"7","key":"2024021014294448500_jbmr3524-bib-0054","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ejmg.2014.04.015","article-title":"Progressive cognitive decline in an adult patient with cleidocranial dysplasia","volume":"57","author":"Takenouchi","year":"2014","journal-title":"Eur J Med Genet"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/10\/1813\/56649358\/jbmr3524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/33\/10\/1813\/56649358\/jbmr3524.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:02:15Z","timestamp":1710342135000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/33\/10\/1813-1825\/7605178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":54,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,6,15]]},"published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3524","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10,1]]},"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"2018-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}