{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:01:16Z","timestamp":1793106076874,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK069350"],"award-info":[{"award-number":["R01 DK069350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK32333"],"award-info":[{"award-number":["DK32333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK067619"],"award-info":[{"award-number":["K23DK067619"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 FD002525"],"award-info":[{"award-number":["R01 FD002525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. Recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] in short-term studies has beneficial skeletal effects. Although rhPTH(1-84) will likely be used indefinitely, long-term effects on skeletal microstructure are unknown. We therefore studied histomorphometric changes with transiliac crest bone biopsies before and after 8.3\u2009\u00b1\u20091 years of rhPTH(1-84) in 13 hypoparathyroid subjects compared with 45 controls. Before institution of rhPTH(1-84), skeletal remodeling indices were markedly suppressed. With long-term treatment, indices of bone remodeling increased. Mineralizing surface increased by 26-fold (0.3\u2009\u00b1\u20091 to 7.9\u2009\u00b1\u20097%, p\u2009=\u20090.003), bone formation rate increased by 15-fold (0.003\u2009\u00b1\u20090.01 to 0.047\u2009\u00b1\u20090.05\u2009\u03bcm2\/\u03bcm\/day, p\u2009=\u20090.007), osteoid width doubled (1.9\u2009\u00b1\u20091 to 4.3\u2009\u00b1\u20091 lamellae, p\u2009=\u20090.017), and osteoid surface tripled (3.3\u2009\u00b1\u20093 to 10.8\u2009\u00b1\u20096%, p\u2009=\u20090.011). Bone resorption as measured by eroded surface increased (4.6\u2009\u00b1\u20092 to 7.5\u2009\u00b1\u20093%, p\u2009=\u20090.021). Structural changes demonstrated intratrabecular tunneling, with increases in cancellous bone volume (19.6\u2009\u00b1\u20095 to 29.1\u2009\u00b1\u200911%, p\u2009=\u20090.017) and trabecular number (1.8\u2009\u00b1\u20091 to 2.5\u2009\u00b1\u20091 #\/mm, p\u2009=\u20090.025). Cortical porosity tended to increase (6.3\u2009\u00b1\u20095 to 9.5\u2009\u00b1\u20093%, p\u2009=\u20090.07). Mineralizing surface, osteoid surface, and eroded surface surpassed control levels, as did cancellous bone volume, trabecular number, and cortical porosity. These data, the first to reflect such long exposure of any PTH for any disease, illustrate that PTH establishes and maintains a new skeletal state for at least 8 years in hypoparathyroidism. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3543","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T21:14:07Z","timestamp":1530738847000},"page":"1931-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Effects of Long-term Administration of rhPTH(1-84) in Hypoparathyroidism by Bone Histomorphometry"],"prefix":"10.1093","volume":"33","author":[{"given":"Mishaela R","family":"Rubin","sequence":"first","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Regional Bone CenterHelen Hayes HospitalWest HaverstrawNew YorkUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie E","family":"Cusano","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukshana","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Omeragic","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Nickolas","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Dempster","sequence":"additional","affiliation":[{"name":"Department of PathologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"},{"name":"Regional Bone CenterHelen Hayes HospitalWest HaverstrawNew YorkUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of MedicineMetabolic Bone Diseases UnitDivision of EndocrinologyCollege of Physicians & SurgeonsColumbia UniversityNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"issue":"4","key":"2024021014284297600_jbmr3543-bib-0001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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