{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:39:27Z","timestamp":1790224767483,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE027046"],"award-info":[{"award-number":["DE027046"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85900"],"award-info":[{"award-number":["85900"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>\u2003<\/jats:title><jats:p>Heterotopic ossification is the abnormal formation of mineralized bone in skin, muscle, tendon, or other soft tissues. Tendon ossification often occurs from acute tendon injury or chronic tendon degeneration, for which current treatment relies heavily on surgical removal of the ectopic bony tissues. Unfortunately, surgery creates additional trauma, which often causes recurrence of heterotopic ossification. The molecular mechanisms of heterotopic ossification are not well understood. Previous studies demonstrate that Mkx is a transcription factor crucial for postnatal tendon fibril growth. Here we report that Mkx\u2013\/\u2013 mutant mice exhibit ectopic ossification in the Achilles tendon within 1 month after birth and the tendon ossification deteriorates with age. Genetic lineage labeling revealed that the tendon ossification in Mkx\u2013\/\u2013 mice resulted from aberrant differentiation of tendon progenitor cells. Furthermore, tissue-specific inactivation of Mkx in tendon cells postnatally resulted in a similar ossification phenotype, indicating that Mkx plays a key role in tendon tissue homeostasis. Moreover, we show that Hedgehog signaling is ectopically activated at early stages of tendon ossification and that tissue-specific inactivation of Smoothened, which encodes the obligatory transducer of Hedgehog signaling, in the tendon cell lineage prevented or dramatically reduced tendon ossification in Mkx\u2013\/\u2013 mice. Together, these studies establish a new genetic mouse model of tendon ossification and provide new insight into its pathogenic mechanisms. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbmr.3630","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T21:11:02Z","timestamp":1542748262000},"page":"557-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<i>Mkx<\/i>-Deficient Mice Exhibit Hedgehog Signaling\u2013Dependent Ectopic Ossification in the Achilles Tendons"],"prefix":"10.1093","volume":"34","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Developmental BiologyCincinnati Children's Hospital Medical CenterCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Developmental BiologyCincinnati Children's Hospital Medical CenterCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children\u2013CincinnatiCincinnatiOHUSA"},{"name":"Department of PediatricsUniversity of Cincinnati College of MedicineCincinnatiOHUSA"},{"name":"Division of Plastic SurgeryCincinnati Children's Hospital Medical CenterCincinnatiOHUSA"},{"name":"Division of Developmental BiologyCincinnati Children's Hospital Medical CenterCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"2024021014524111700_jbmr3630-bib-0001","first-page":"1281","article-title":"Molecular and cellular mechanisms of heterotopic ossification","volume":"29","author":"Ramirez","year":"2014","journal-title":"Histol Histopathol"},{"key":"2024021014524111700_jbmr3630-bib-0002","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2017.05.035","article-title":"Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing","volume":"169","author":"Zheng","year":"2017","journal-title":"Cell"},{"key":"2024021014524111700_jbmr3630-bib-0003","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.trsl.2017.06.004","article-title":"The traumatic bone: trauma-induced heterotopic ossification","volume":"186","author":"Dey","year":"2017","journal-title":"Transl Res"},{"issue":"4","key":"2024021014524111700_jbmr3630-bib-0004","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/jor.23808","article-title":"Post-traumatic heterotopic ossification: an old problem in need of new solutions","volume":"36","author":"Eisenstein","year":"2018","journal-title":"J Orthop Res"},{"key":"2024021014524111700_jbmr3630-bib-0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJMoa011262","article-title":"Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia","volume":"346","author":"Shore","year":"2002","journal-title":"N Engl J Med"},{"key":"2024021014524111700_jbmr3630-bib-0006","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat Genet"},{"key":"2024021014524111700_jbmr3630-bib-0007","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrrheum.2010.122","article-title":"Inherited human diseases of heterotopic bone formation","volume":"6","author":"Shore","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"2024021014524111700_jbmr3630-bib-0008","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/nm.3314","article-title":"Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification","volume":"19","author":"Regard","year":"2013","journal-title":"Nat Med"},{"key":"2024021014524111700_jbmr3630-bib-0009","doi-asserted-by":"crossref","first-page":"303ra137","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci Transl Med"},{"key":"2024021014524111700_jbmr3630-bib-0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bone.2017.11.014","article-title":"Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP)","volume":"109","author":"Wang","year":"2018","journal-title":"Bone"},{"key":"2024021014524111700_jbmr3630-bib-0011","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jor.22500","article-title":"A novel mouse model of trauma induced heterotopic ossification","volume":"32","author":"Liu","year":"2014","journal-title":"J Orthop Res"},{"key":"2024021014524111700_jbmr3630-bib-0012","doi-asserted-by":"crossref","first-page":"255ra132","DOI":"10.1126\/scitranslmed.3008810","article-title":"Treatment of heterotopic ossification through remote ATP hydrolysis","volume":"6","author":"Peterson","year":"2014","journal-title":"Sci Transl Med"},{"key":"2024021014524111700_jbmr3630-bib-0013","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/BOT.0b013e3181ed147b","article-title":"The genetics of heterotopic ossification: insight into the bone remodeling pathway","volume":"24","author":"Mitchell","year":"2010","journal-title":"J Orthop Trauma"},{"key":"2024021014524111700_jbmr3630-bib-0014","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2613.2012.00829.x","article-title":"Heterotopic mineralization (ossification or calcification) in tendinopathy or following surgical tendon trauma","volume":"93","author":"O'Brien","year":"2012","journal-title":"Int J Exp Pathol"},{"key":"2024021014524111700_jbmr3630-bib-0015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/JSA.0b013e318225bc5f","article-title":"Calcific tendinopathy of the rotator cuff tendons","volume":"19","author":"Oliva","year":"2011","journal-title":"Sports Med Arthrosc Rev"},{"key":"2024021014524111700_jbmr3630-bib-0016","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2106\/00004623-199173100-00009","article-title":"Histopathological changes preceding spontaneous rupture of a tendon","volume":"73","author":"Kannus","year":"1991","journal-title":"A controlled study of 891 patients. J Bone Joint Surg Am"},{"key":"2024021014524111700_jbmr3630-bib-0017","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1080\/09638280701785866","article-title":"Achilles tendon ossification: pathology, imaging and aetiology","volume":"30","author":"Richards","year":"2008","journal-title":"Disabil Rehabil"},{"key":"2024021014524111700_jbmr3630-bib-0018","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/stem.2515","article-title":"Scleraxis-lineage cells contribute to ectopic bone formation in muscle and tendon","volume":"35","author":"Agarwal","year":"2017","journal-title":"Stem Cells"},{"key":"2024021014524111700_jbmr3630-bib-0019","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/dev.128.19.3855","article-title":"Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments","volume":"128","author":"Schweitzer","year":"2001","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0020","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/dvdy.21179","article-title":"Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene","volume":"236","author":"Pryce","year":"2007","journal-title":"Dev Dyn"},{"key":"2024021014524111700_jbmr3630-bib-0021","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1073\/pnas.1522054113","article-title":"Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis","volume":"113","author":"Suzuki","year":"2016","journal-title":"Proc Natl Acad Sci U S.A"},{"key":"2024021014524111700_jbmr3630-bib-0022","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1128\/MCB.00207-10","article-title":"The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis","volume":"30","author":"Liu","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2024021014524111700_jbmr3630-bib-0023","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1242\/dev.128.24.5099","article-title":"Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation","volume":"128","author":"Long","year":"2001","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0024","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"2024021014524111700_jbmr3630-bib-0026","doi-asserted-by":"crossref","first-page":"45238","DOI":"10.1038\/srep45238","article-title":"Novel model of tendon regeneration reveals distinct cell mechanisms underlying regenerative and fibrotic tendon healing","volume":"7","author":"Howell","year":"2017","journal-title":"Sci Rep"},{"key":"2024021014524111700_jbmr3630-bib-0027","doi-asserted-by":"crossref","first-page":"18555","DOI":"10.1073\/pnas.1306495110","article-title":"Odd-skipped related-1 controls neural crest chondrogenesis during tongue development","volume":"110","author":"Liu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024021014524111700_jbmr3630-bib-0028","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1242\/dev.103283","article-title":"Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis","volume":"141","author":"Xu","year":"2014","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0029","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/biores.2014.0017","article-title":"High resolution x-ray: a reliable approach for quantifying osteoporosis in a rodent model","volume":"3","author":"Velasco","year":"2014","journal-title":"Biores Open Access"},{"key":"2024021014524111700_jbmr3630-bib-0030","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.joca.2014.06.021","article-title":"Quantification of differences in bone texture from plain radiographs in knees with and without osteoarthritis","volume":"22","author":"Hirvasniemi","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"2024021014524111700_jbmr3630-bib-0031","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/jor.21550","article-title":"Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts","volume":"30","author":"Mendias","year":"2012","journal-title":"J Orthop Res"},{"key":"2024021014524111700_jbmr3630-bib-0032","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/8792","article-title":"Sox9 is required for cartilage formation","volume":"22","author":"Bi","year":"1999","journal-title":"Nat Genet"},{"key":"2024021014524111700_jbmr3630-bib-0033","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1101\/gad.1017802","article-title":"The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6","volume":"16","author":"Akiyama","year":"2002","journal-title":"Genes Dev"},{"key":"2024021014524111700_jbmr3630-bib-0034","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1073\/pnas.0504750102","article-title":"Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors","volume":"102","author":"Akiyama","year":"2005","journal-title":"Proc Natl Acad Sci U S.A"},{"key":"2024021014524111700_jbmr3630-bib-0035","first-page":"977","article-title":"Microenvironmental factors that regulate mesenchymal stem cells: lessons learned from the study of heterotopic ossification","volume":"32","author":"Kan","year":"2017","journal-title":"Histol Histopathol"},{"key":"2024021014524111700_jbmr3630-bib-0036","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins: multifunctional regulators of vertebrate development","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev"},{"key":"2024021014524111700_jbmr3630-bib-0037","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(00)81250-7","article-title":"MADR1, a MAD-related protein that functions in BMP2 signaling pathways","volume":"85","author":"Hoodless","year":"1996","journal-title":"Cell"},{"key":"2024021014524111700_jbmr3630-bib-0038","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1101\/gad.11.8.984","article-title":"The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase","volume":"11","author":"Kretzschmar","year":"1997","journal-title":"Genes Dev"},{"key":"2024021014524111700_jbmr3630-bib-0039","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1101\/gad.12.16.2445","article-title":"Smads and early developmental signaling by the TGFbeta superfamily","volume":"12","author":"Whitman","year":"1998","journal-title":"Genes Dev"},{"issue":"Suppl 1","key":"2024021014524111700_jbmr3630-bib-0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2106\/JBJS.G.01174","article-title":"Wnt and hedgehog signaling pathways in bone development","volume":"90","author":"Day","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"2024021014524111700_jbmr3630-bib-0041","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/jor.22899","article-title":"Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis","volume":"33","author":"Breidenbach","year":"2015","journal-title":"J Orthop Res"},{"key":"2024021014524111700_jbmr3630-bib-0042","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1242\/dev.112714","article-title":"Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment","volume":"142","author":"Schwartz","year":"2015","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0043","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1242\/dev.139303","article-title":"Enthesis regeneration: a role for Gli1+ progenitor cells","volume":"144","author":"Schwartz","year":"2017","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0044","doi-asserted-by":"crossref","first-page":"e65411","DOI":"10.1371\/journal.pone.0065411","article-title":"A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"2024021014524111700_jbmr3630-bib-0045","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/39918","article-title":"Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours","volume":"389","author":"Dahmane","year":"1997","journal-title":"Nature"},{"key":"2024021014524111700_jbmr3630-bib-0046","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.124.13.2537","article-title":"Gli1 is a target of Sonic hedgehog that induces ventral neural tube development","volume":"124","author":"Lee","year":"1997","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0047","first-page":"181","article-title":"Biology of tendon injury: healing, modeling and remodeling","volume":"6","author":"Sharma","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2024021014524111700_jbmr3630-bib-0048","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0838.1997.tb00124.x","article-title":"Histopathological findings in chronic tendon disorders","volume":"7","author":"Jarvinen","year":"1997","journal-title":"Scand J Med Sci Sports"},{"key":"2024021014524111700_jbmr3630-bib-0049","doi-asserted-by":"crossref","first-page":"10538","DOI":"10.1073\/pnas.1000525107","article-title":"The Mohawk homeobox gene is a critical regulator of tendon differentiation","volume":"107","author":"Ito","year":"2010","journal-title":"Proc Natl Acad Sci U S.A"},{"key":"2024021014524111700_jbmr3630-bib-0050","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/nm1630","article-title":"Identification of tendon stem\/progenitor cells and the role of the extracellular matrix in their niche","volume":"13","author":"Bi","year":"2007","journal-title":"Nat Med"},{"key":"2024021014524111700_jbmr3630-bib-0051","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1096\/fj.01-0848com","article-title":"Abnormal collagen fibrils in tendons of biglycan\/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis","volume":"16","author":"Ameye","year":"2002","journal-title":"FASEB J"},{"key":"2024021014524111700_jbmr3630-bib-0052","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/rheumatology\/41.4.474","article-title":"Endochondral ossification in Achilles and patella tendinopathy","volume":"41","author":"Fenwick","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"2024021014524111700_jbmr3630-bib-0053","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1242\/dev.093906","article-title":"Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors","volume":"140","author":"Blitz","year":"2013","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0054","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1242\/dev.096354","article-title":"Scx+\/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon\/ligament","volume":"140","author":"Sugimoto","year":"2013","journal-title":"Development"},{"key":"2024021014524111700_jbmr3630-bib-0055","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1053\/jars.2002.30646","article-title":"The trans-rotator cuff approach to SLAP lesions: technical aspects for repair and a clinical follow-up of 31 patients at a minimum of 2 years","volume":"18","author":"O'Brien","year":"2002","journal-title":"Arthroscopy"},{"key":"2024021014524111700_jbmr3630-bib-0056","first-page":"539740","article-title":"Could ossification of the Achilles tendon have a hereditary component","volume":"2013","author":"Cortbaoui","year":"2013","journal-title":"Case Rep Orthop"},{"key":"2024021014524111700_jbmr3630-bib-0057","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.fas.2014.07.005","article-title":"An atraumatic case of extensive Achilles tendon ossification","volume":"20","author":"Ross","year":"2014","journal-title":"Foot Ankle Surg"},{"key":"2024021014524111700_jbmr3630-bib-0058","first-page":"2058460115599184","article-title":"Ossification of the bilateral Achilles tendon: a rare entity","volume":"4","author":"Arora","year":"2015","journal-title":"Acta Radiol Open"},{"key":"2024021014524111700_jbmr3630-bib-0059","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/MCB.00950-15","article-title":"Gtf2ird1-dependent Mohawk expression regulates mechanosensing properties of the tendon","volume":"36","author":"Kayama","year":"2016","journal-title":"Mol Cell Biol"},{"key":"2024021014524111700_jbmr3630-bib-0060","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/art.38020","article-title":"Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation","volume":"65","author":"Nakahara","year":"2013","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.3630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.3630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/3\/557\/56655989\/jbmr3630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/3\/557\/56655989\/jbmr3630.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T16:15:44Z","timestamp":1720800944000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/34\/3\/557-569\/7606025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,11,20]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3630","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3,1]]},"published":{"date-parts":[[2018,11,20]]},"assertion":[{"value":"2018-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}