{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:45:16Z","timestamp":1790048716802,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":1839,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["298625"],"award-info":[{"award-number":["298625"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["268535"],"award-info":[{"award-number":["268535"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["139165"],"award-info":[{"award-number":["139165"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Human genetic evidence demonstrates that WNT1 mutations cause osteogenesis imperfecta (OI) and early-onset osteoporosis, implicating WNT1 as a major regulator of bone metabolism. However, its main cellular source and mechanisms of action in bone remain elusive. We generated global and limb bud mesenchymal cell\u2013targeted deletion of Wnt1 in mice. Heterozygous deletion of Wnt1 resulted in mild trabecular osteopenia due to decreased osteoblast function. Targeted deletion of Wnt1 in mesenchymal progenitors led to spontaneous fractures due to impaired osteoblast function and increased bone resorption, mimicking the severe OI phenotype in humans with homozygous WNT1 mutations. Importantly, we showed for the first time that Wnt1 signals strictly in a juxtacrine manner to induce osteoblast differentiation and to suppress osteoclastogenesis, in part via canonical Wnt signaling. In conclusion, mesenchymal cell-derived Wnt1, acting in short range, is an essential regulator of bone homeostasis and an intriguing target for therapeutic interventions for bone diseases. \u00a9 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3680","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:26:57Z","timestamp":1548732417000},"page":"1129-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation"],"prefix":"10.1093","volume":"34","author":[{"given":"Fan","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Tarkkonen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vappu","family":"Nieminen-Pihala","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine Harvard University BostonMA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Al","family":"Majidi","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Puolakkainen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Rummukainen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemina","family":"Lehto","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roivainen","sequence":"additional","affiliation":[{"name":"Turku Center for Disease Modeling (TCDM) University of Turku Turku Finland"},{"name":"Turku PET Centre University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Turku Center for Disease Modeling (TCDM) University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Folkh\u00e4lsan Institute of Genetics Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine Harvard University BostonMA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riku","family":"Kiviranta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Division of Medicine University of Turku and Turku University Hospital Turku Finland"},{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"issue":"5","key":"2024021014431246600_jbmr3680-bib-0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/jmedgenet-2013-101567","article-title":"Mutations in WNT1 are a cause of osteogenesis imperfecta","volume":"50","author":"Fahiminiya","year":"2013","journal-title":"J Med Genet"},{"issue":"4","key":"2024021014431246600_jbmr3680-bib-0002","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ajhg.2013.02.010","article-title":"Mutations in WNT1 cause different forms of bone fragility","volume":"92","author":"Keupp","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"19","key":"2024021014431246600_jbmr3680-bib-0003","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1215458","article-title":"WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta","volume":"368","author":"Laine","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"2024021014431246600_jbmr3680-bib-0004","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajhg.2013.02.009","article-title":"WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta","volume":"92","author":"Pyott","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"20","key":"2024021014431246600_jbmr3680-bib-0005","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa013444","article-title":"High bone density due to a mutation in LDL-receptor-related protein 5","volume":"346","author":"Boyden","year":"2002","journal-title":"N Engl J Med"},{"issue":"3","key":"2024021014431246600_jbmr3680-bib-0006","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1086\/318811","article-title":"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein","volume":"68","author":"Brunkow","year":"2001","journal-title":"Am J Hum Genet"},{"issue":"4","key":"2024021014431246600_jbmr3680-bib-0007","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"issue":"16","key":"2024021014431246600_jbmr3680-bib-0008","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N Engl J Med"},{"issue":"10","key":"2024021014431246600_jbmr3680-bib-0009","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejmg.2012.06.011","article-title":"Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis","volume":"55","author":"Korvala","year":"2012","journal-title":"Eur J Med Genet"},{"issue":"1","key":"2024021014431246600_jbmr3680-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on Wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene"},{"issue":"7","key":"2024021014431246600_jbmr3680-bib-0011","doi-asserted-by":"crossref","first-page":"e1002745","DOI":"10.1371\/journal.pgen.1002745","article-title":"WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk","volume":"8","author":"Zheng","year":"2012","journal-title":"PLoS Genet"},{"issue":"5","key":"2024021014431246600_jbmr3680-bib-0012","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass","year":"2005","journal-title":"Dev Cell"},{"issue":"4","key":"2024021014431246600_jbmr3680-bib-0013","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bbrc.2015.06.102","article-title":"Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a","volume":"463","author":"Kobayashi","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2024021014431246600_jbmr3680-bib-0014","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.3654","article-title":"Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures","volume":"20","author":"Moverare-Skrtic","year":"2014","journal-title":"Nat Med"},{"issue":"7","key":"2024021014431246600_jbmr3680-bib-0015","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1172\/JCI92617","article-title":"Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis","volume":"127","author":"Joeng","year":"2017","journal-title":"J Clin Invest"},{"issue":"1","key":"2024021014431246600_jbmr3680-bib-0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvw071","article-title":"Differences in the secretion and transport of Wnt proteins","volume":"161","author":"Takada","year":"2017","journal-title":"J Biochem"},{"issue":"7482","key":"2024021014431246600_jbmr3680-bib-0017","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature12879","article-title":"Patterning and growth control by membrane-tethered Wingless","volume":"505","author":"Alexandre","year":"2014","journal-title":"Nature"},{"issue":"7590","key":"2024021014431246600_jbmr3680-bib-0018","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature16937","article-title":"Visualization of a short-range Wnt gradient in the intestinal stem-cell niche","volume":"530","author":"Farin","year":"2016","journal-title":"Nature"},{"issue":"3","key":"2024021014431246600_jbmr3680-bib-0019","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2006.02.049","article-title":"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells","volume":"125","author":"Banziger","year":"2006","journal-title":"Cell"},{"issue":"24","key":"2024021014431246600_jbmr3680-bib-0020","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1101\/gad.10.24.3116","article-title":"The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing","volume":"10","author":"Kadowaki","year":"1996","journal-title":"Genes Dev"},{"issue":"5","key":"2024021014431246600_jbmr3680-bib-0021","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/j.1460-2075.1990.tb08276.x","article-title":"The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix","volume":"9","author":"Bradley","year":"1990","journal-title":"EMBO J"},{"issue":"32","key":"2024021014431246600_jbmr3680-bib-0022","doi-asserted-by":"crossref","first-page":"33220","DOI":"10.1074\/jbc.M403407200","article-title":"Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine","volume":"279","author":"Zhai","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"2024021014431246600_jbmr3680-bib-0023","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(90)90385-R","article-title":"The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain","volume":"62","author":"McMahon","year":"1990","journal-title":"Cell"},{"issue":"4","key":"2024021014431246600_jbmr3680-bib-0024","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0092-8674(88)90220-6","article-title":"Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice","volume":"55","author":"Tsukamoto","year":"1988","journal-title":"Cell"},{"issue":"2","key":"2024021014431246600_jbmr3680-bib-0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10238-010-0110-9","article-title":"Wnt\/beta-Catenin pathway in human glioma: expression pattern and clinical\/prognostic correlations","volume":"11","author":"Liu","year":"2011","journal-title":"Clin Exp Med"},{"issue":"2","key":"2024021014431246600_jbmr3680-bib-0026","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/path.1035","article-title":"Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours","volume":"196","author":"Wong","year":"2002","journal-title":"J Pathol"},{"issue":"15","key":"2024021014431246600_jbmr3680-bib-0027","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1093\/hmg\/ddu117","article-title":"The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations","volume":"23","author":"Joeng","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2024021014431246600_jbmr3680-bib-0028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"issue":"1","key":"2024021014431246600_jbmr3680-bib-0029","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"57","key":"2024021014431246600_jbmr3680-bib-0030","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1038\/sj.onc.1210053","article-title":"Wnts as ligands: processing, secretion and reception","volume":"25","author":"Mikels","year":"2006","journal-title":"Oncogene"},{"issue":"12","key":"2024021014431246600_jbmr3680-bib-0031","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.addr.2010.09.012","article-title":"The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators","volume":"62","author":"Teo","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"2024021014431246600_jbmr3680-bib-0032","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2009.00821.x","article-title":"Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation","volume":"231","author":"Negishi-Koga","year":"2009","journal-title":"Immunol Rev"},{"issue":"24","key":"2024021014431246600_jbmr3680-bib-0033","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"98","author":"Bennett","year":"2001","journal-title":"Proc Natl Acad Sci U S.A"},{"issue":"Pt B","key":"2024021014431246600_jbmr3680-bib-0034","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yjmcc.2015.10.012","article-title":"KN-93 inhibits IKr in mammalian cardiomyocytes","volume":"89","author":"Hegyi","year":"2015","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"2024021014431246600_jbmr3680-bib-0035","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/cb100323z","article-title":"Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt\/beta-catenin signaling","volume":"6","author":"Wang","year":"2011","journal-title":"ACS Chem Biol"},{"issue":"2","key":"2024021014431246600_jbmr3680-bib-0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat Med"},{"issue":"26","key":"2024021014431246600_jbmr3680-bib-0037","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1056\/NEJMoa1509342","article-title":"Cortical-bone fragility\u2014insights from sFRP4 deficiency in Pyle's disease","volume":"374","author":"Kiper","year":"2016","journal-title":"N Engl J Med"},{"issue":"35","key":"2024021014431246600_jbmr3680-bib-0038","doi-asserted-by":"crossref","first-page":"15473","DOI":"10.1073\/pnas.1007428107","article-title":"Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies","volume":"107","author":"Ettenberg","year":"2010","journal-title":"Proc Natl Acad Sci U S.A"},{"issue":"5","key":"2024021014431246600_jbmr3680-bib-0039","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","article-title":"Wnt\/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis","volume":"8","author":"Day","year":"2005","journal-title":"Dev Cell"},{"issue":"5","key":"2024021014431246600_jbmr3680-bib-0040","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","article-title":"Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes","volume":"8","author":"Hill","year":"2005","journal-title":"Dev Cell"},{"issue":"12","key":"2024021014431246600_jbmr3680-bib-0041","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.01428-09","article-title":"Osteocyte Wnt\/beta-catenin signaling is required for normal bone homeostasis","volume":"30","author":"Kramer","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"46","key":"2024021014431246600_jbmr3680-bib-0042","doi-asserted-by":"crossref","first-page":"24160","DOI":"10.1074\/jbc.M116.751974","article-title":"Heparan sulfate regulates the structure and function of osteoprotegerin in osteoclastogenesis","volume":"291","author":"Li","year":"2016","journal-title":"J Biol Chem"},{"issue":"3","key":"2024021014431246600_jbmr3680-bib-0043","doi-asserted-by":"crossref","first-page":"e89624","DOI":"10.1172\/jci.insight.89624","article-title":"Osteoblastic heparan sulfate regulates osteoprotegerin function and bone mass","volume":"3","author":"Nozawa","year":"2018","journal-title":"JCI Insight"},{"issue":"3","key":"2024021014431246600_jbmr3680-bib-0044","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nm.2653","article-title":"Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis","volume":"18","author":"Maeda","year":"2012","journal-title":"Nat Med"},{"issue":"6205","key":"2024021014431246600_jbmr3680-bib-0045","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","article-title":"Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control","volume":"346","author":"Clevers","year":"2014","journal-title":"Science"},{"issue":"10","key":"2024021014431246600_jbmr3680-bib-0046","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ncb2574","article-title":"Active Wnt proteins are secreted on exosomes","volume":"14","author":"Gross","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"33","key":"2024021014431246600_jbmr3680-bib-0047","doi-asserted-by":"crossref","first-page":"E2197","DOI":"10.1073\/pnas.1120407109","article-title":"Wntless functions in mature osteoblasts to regulate bone mass","volume":"109","author":"Zhong","year":"2012","journal-title":"Proc Natl Acad Sci U S.A"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.3680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.3680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.3680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/6\/1129\/56655572\/jbmr3680.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/6\/1129\/56655572\/jbmr3680.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:03:30Z","timestamp":1710342210000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/34\/6\/1129-1142\/7605980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,1,28]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3680","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6,1]]},"published":{"date-parts":[[2019,1,28]]},"assertion":[{"value":"2018-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}