{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:50:11Z","timestamp":1790715011849,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":1831,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2\u2013\/\u2013 mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2\u2013\/\u2013 mice: yield load (\u20132.3 SD), maximum load (\u20131.7 SD), and stiffness (\u20132.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wild-type controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength. \u00a9 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3691","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T20:47:04Z","timestamp":1549399624000},"page":"1101-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["<i>Slc20a2<\/i>, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength"],"prefix":"10.1093","volume":"34","author":[{"given":"Sarah","family":"Beck-Cormier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Nantes Unit\u00e9 de Formation et de Recherche (UFR) Odontologie Nantes France"},{"name":"INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Universit\u00e9 de Nantes, \u00c9cole Nationale V\u00e9t\u00e9rinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique (ONIRIS) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Lelliott","sequence":"additional","affiliation":[{"name":"Mouse Pipelines Wellcome Trust Sanger Institute Hinxton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Logan","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory Department of Medicine Imperial College LondonLondon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Lafont","sequence":"additional","affiliation":[{"name":"Mouse Pipelines Wellcome Trust Sanger Institute Hinxton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Merametdjian","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Nantes P\u00f4les Hospitalo-Universitaires (PHU4) - Ost\u00e9o-articulaire - T\u00eate et Cou - Odontologie - Neurochirurgie - Neuro-traumatologie (OTONN) Nantes France"},{"name":"Universit\u00e9 de Nantes Unit\u00e9 de Formation et de Recherche (UFR) Odontologie Nantes France"},{"name":"INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Universit\u00e9 de Nantes, \u00c9cole Nationale V\u00e9t\u00e9rinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique (ONIRIS) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria D","family":"Leitch","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory Department of Medicine Imperial College LondonLondon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie C","family":"Butterfield","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory Department of Medicine Imperial College LondonLondon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley J","family":"Protheroe","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory Department of Medicine Imperial College LondonLondon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter I","family":"Croucher","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School, Faculty of Medicine University of New South Wales (UNSW) Australia SydneyNSW Australia"},{"name":"The Garvan Institute of Medical Research SydneyNSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Baldock","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School, Faculty of Medicine University of New South Wales (UNSW) Australia SydneyNSW Australia"},{"name":"The Garvan Institute of Medical Research SydneyNSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Gaultier-Lintia","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Nantes Laennec Hospital Nantes 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(UNIROUEN) Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Banse","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Soissons Hospital Soissons France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Normant","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Magne","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"G\u00e9rardin","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Rouen University Hospital Rouen 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Guicheux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Nantes P\u00f4les Hospitalo-Universitaires (PHU4) - Ost\u00e9o-articulaire - T\u00eate et Cou - Odontologie - Neurochirurgie - Neuro-traumatologie (OTONN) Nantes France"},{"name":"Universit\u00e9 de Nantes Unit\u00e9 de Formation et de Recherche (UFR) Odontologie Nantes France"},{"name":"INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Universit\u00e9 de Nantes, \u00c9cole Nationale V\u00e9t\u00e9rinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique (ONIRIS) Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Beck","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes Unit\u00e9 de Formation et de Recherche (UFR) Odontologie Nantes France"},{"name":"INSERM, UMR 1229, Regenerative Medicine and Skeleton 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