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The present study found that 50-Hz sinusoidal electromagnetic fields (SEMFs) at 1.8 mT increased the peak bone mass of young rats by increasing bone formation. Gene array expression studies with femoral bone samples showed that SEMFs increased the expression levels of collagen-1\u03b11 and Wnt10b, a critical ligand of the osteogenic Wnt\/\u03b2-catenin pathway. Consistently, SEMFs promoted osteogenic differentiation and maturation of rat calvarial osteoblasts (ROBs) in vitro through activating the Wnt10b\/\u03b2-catenin pathway. This osteogenesis-promoting effect of SEMFs via Wnt10b\/\u03b2-catenin signaling was found to depend on the functional integrity of primary cilia in osteoblasts. When the primary cilia were abrogated by small interfering RNA (siRNA) targeting IFT88, the ability of SEMFs to promote the osteogenic differentiation of ROBs through activating Wnt10b\/\u03b2-catenin signaling was blocked. Although the knockdown of Wnt10b expression with RNA interference had no effect on primary cilia, it significantly suppressed the promoting effect of SEMFs on osteoblastic differentiation\/maturation. Wnt10b was normally localized at the bases of primary cilia, but it disappeared (or was released) from the cilia upon SEMF treatment. Interestingly, primary cilia were elongated to different degrees by different intensities of 50-Hz SEMFs, with the window effect observed at 1.8\u2009mT, and the expression level of Wnt10b increased in accord with the lengths of primary cilia. These results indicate that 50-Hz 1.8-mT SEMFs increase the peak bone mass of growing rats by promoting osteogenic differentiation\/maturation of osteoblasts, which is mediated, at least in part, by Wnt10b at the primary cilia and the subsequent activation of Wnt\/\u03b2-catenin signaling. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.3704","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T18:48:36Z","timestamp":1550602116000},"page":"1336-1351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b\/\u03b2-Catenin in Primary Cilia of Osteoblasts"],"prefix":"10.1093","volume":"34","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of OrthopaedicsLanzhou General HospitalCPLALanzhou 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