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Relative to the skeletal fragility, muscle weakness is much less understood. Recent investigations into OI muscle weakness in both patients and mouse models have revealed the presence of an inherent muscle pathology. Understanding the mechanisms responsible for OI muscle weakness is critical, particularly in light of the extensive cross-talk between muscle and bone via mechanotransduction and biochemical signaling. In the following study we initially subjected WT and oim\/oim mice, modeling severe human OI type III, to either weight-bearing (voluntary wheel-running) or non-weight-bearing (swimming) exercise regimens as a modality to improve muscle strength and ultimately bone strength. The oim\/oim mice ran only 35% to 42% of the distance run by age- and sex-matched WT mice and exhibited little improvement with either exercise regimen. Upon further investigation, we determined that oim\/oim gastrocnemius muscle exhibited severe mitochondrial dysfunction as characterized by a 52% to 65% decrease in mitochondrial respiration rates, alterations in markers of mitochondrial biogenesis, mitophagy, and the electron transport chain components, as well as decreased mitochondrial citrate synthase activity, relative to age- and sex-matched WT gastrocnemius muscle. Thus, mitochondrial dysfunction in the oim\/oim mouse likely contributes to compromised muscle function and reduced physical activity levels. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3732","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:06:42Z","timestamp":1553540802000},"page":"1646-1659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Compromised Exercise Capacity and Mitochondrial Dysfunction in the Osteogenesis Imperfecta Murine (<i>oim<\/i>) Mouse Model"],"prefix":"10.1093","volume":"34","author":[{"given":"Victoria L","family":"Gremminger","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-5702","authenticated-orcid":false,"given":"Youngjae","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory P","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Departments of Nutrition and Exercise Physiology and Medicine-GI University of Missouri; Research Service-Harry S Truman Memorial VA Hospital Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace M","family":"Meers","sequence":"additional","affiliation":[{"name":"Departments of Nutrition and Exercise Physiology and Medicine-GI University of Missouri; Research Service-Harry S Truman Memorial VA Hospital Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Scott","family":"Rector","sequence":"additional","affiliation":[{"name":"Departments of Nutrition and Exercise Physiology and Medicine-GI University of Missouri; Research Service-Harry S Truman Memorial VA Hospital Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte L","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Missouri Columbia MO USA"},{"name":"Department of Biochemistry University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"2024021014435682400_jbmr3732-bib-0001","doi-asserted-by":"crossref","first-page":"17052","DOI":"10.1038\/nrdp.2017.52","article-title":"Osteogenesis imperfecta","volume":"3","author":"Marini","year":"2017","journal-title":"Nat Rev Dis 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