{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:54:00Z","timestamp":1784876040507,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["NIH 1 Z01 DE000649"],"award-info":[{"award-number":["NIH 1 Z01 DE000649"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of 18F-NaF PET\/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole-body 18F-NaF PET\/CT scans, and FD burden was assessed by quantifying FD-related 18F-NaF activity. 18F-NaF PET\/CT parameters obtained included (i) SUVmax (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUVmean (average SUV of all 18F-NaF\u2013positive FD lesions); (iii) total volume of all 18F-NaF\u2013positive FD lesions (TV); and (iv) total FD lesion activity determined as the product of TV multiplied by SUVmean (TA =\u2009 TV \u00d7\u2009 SUVmean) (TA). Skeletal outcomes, functional outcomes, and bone turnover markers were correlated with 18F-NaF PET\/CT parameters. TV and TA of extracranial FD lesions correlated strongly with skeletal outcomes including fractures and surgeries (p values \u2264\u20090.003). Subjects with impaired ambulation and scoliosis had significantly higher TV and TA values (P &amp;lt;\u20090.05), obtained from extracranial and spinal lesions, respectively. Craniofacial surgeries correlated with TV and TA of skull FD lesions (P &amp;lt;\u20090.001). Bone turnover markers, including alkaline phosphatase, N-telopeptides, and osteocalcin, were strongly correlated with TV and TA (P &amp;lt;\u20090.05) extracted from FD lesions in the entire skeleton. No associations were identified with SUVmax or SUVmean. Bone pain and age did not correlate with 18F-NaF PET\/CT parameters. FD burden evaluated by 18F-NaF-PET\/CT facilitates accurate assessment of FD activity, and correlates quantitatively with clinically-relevant skeletal outcomes. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3738","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:43:36Z","timestamp":1558532616000},"page":"1619-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["18F-N<scp>a<\/scp>F PET\/CT IMAGING IN FIBROUS DYSPLASIA OF BONE"],"prefix":"10.1093","volume":"34","author":[{"given":"Georgios Z","family":"Papadakis","sequence":"first","affiliation":[{"name":"Department of Radiology Medical School, University of Crete Heraklion Greece"},{"name":"Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health Bethesda MD USA"},{"name":"Foundation for Research and Technology (FORTH) Institute of Computer Science (ICS) Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios C","family":"Manikis","sequence":"additional","affiliation":[{"name":"Foundation for Research and Technology (FORTH) Institute of Computer Science (ICS) Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos H","family":"Karantanas","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical School, University of Crete Heraklion Greece"},{"name":"Foundation for Research and Technology (FORTH) Institute of Computer Science (ICS) Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-3146","authenticated-orcid":false,"given":"Pablo","family":"Florenzano","sequence":"additional","affiliation":[{"name":"Endocrinology Department Facultad de Medicina, Pontificia Universidad Catolica de Chile Santiago Chile"},{"name":"Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulas","family":"Bagci","sequence":"additional","affiliation":[{"name":"Center for Research in Computer Vision, University of Central Florida Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Marias","sequence":"additional","affiliation":[{"name":"Foundation for Research and Technology (FORTH) Institute of Computer Science (ICS) Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Collins","sequence":"additional","affiliation":[{"name":"Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health Bethesda MD 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