{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:42Z","timestamp":1787756082536,"version":"build-2784847793"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX000896"],"award-info":[{"award-number":["CX000896"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["U54OH010162"],"award-info":[{"award-number":["U54OH010162"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA036727"],"award-info":[{"award-number":["P30CA036727"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES019325"],"award-info":[{"award-number":["R01ES019325"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115458"],"award-info":[{"award-number":["U54GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R25AA020818"],"award-info":[{"award-number":["R25AA020818"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Rheumatoid arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone\/joint\u2013lung inflammatory outcomes. DBA\/1J mice were intranasally treated with saline or ODE daily for 5 weeks. CIA was induced on days 1 and 21. Treatment groups included sham (saline injection\/saline inhalation), CIA (CIA\/saline), ODE (saline\/ODE), and CIA +\u2009 ODE (CIA\/ODE). Arthritis inflammatory scores, bones, bronchoalveolar lavage fluid, lung tissues, and serum were assessed. In DBA\/1J male mice, arthritis was increased in CIA +\u2009 ODE &amp;gt;\u2009 CIA &amp;gt;\u2009 ODE versus sham. Micro-computed tomography (\u00b5CT) demonstrated that loss of BMD and volume and deterioration of bone microarchitecture was greatest in CIA +\u2009 ODE. However, ODE-induced airway neutrophil influx and inflammatory cytokine\/chemokine levels in lavage fluids were increased in ODE &amp;gt;\u2009 CIA +\u2009 ODE versus sham. Activated lung CD11c+CD11b+ macrophages were increased in ODE &amp;gt;\u2009 CIA +\u2009 ODE &amp;gt;\u2009 CIA pattern, whereas lung hyaluronan, fibronectin, and amphiregulin levels were greatest in CIA +\u2009 ODE. Serum autoantibody and inflammatory marker concentrations varied among experimental groups. Compared with male mice, female mice showed less articular and pulmonary disease. The interaction of inhalation-induced airway inflammation and arthritis induction resulted in compartmentalized responses with the greatest degree of arthritis and bone loss in male mice with combined exposures. Data also support suppression of the lung inflammatory response, but increases in extracellular matrix protein deposition\/interstitial disease in the setting of arthritis. This coexposure model could be exploited to better understand and treat RA\u2013lung disease. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3745","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T20:10:43Z","timestamp":1555531843000},"page":"1733-1743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis"],"prefix":"10.1093","volume":"34","author":[{"given":"Jill A","family":"Poole","sequence":"first","affiliation":[{"name":"Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey 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Research Service Omaha NE USA"},{"name":"Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Carrington","sequence":"additional","affiliation":[{"name":"Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Swanson","sequence":"additional","affiliation":[{"name":"Pathology and Microbiology Department University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynell W","family":"Klassen","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"},{"name":"Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted R","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"},{"name":"Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"key":"2024021014432612900_jbmr3745-bib-0001","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/B978-0-323-31696-5.00070-X","volume-title":"Kelley & Firestein's Textbook of 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