{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:05:57Z","timestamp":1792317957892,"version":"4.4.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["RO1AR49896"],"award-info":[{"award-number":["RO1AR49896"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR054127"],"award-info":[{"award-number":["K23AR054127"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["R01 FD003902"],"award-info":[{"award-number":["R01 FD003902"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Pregnancy and lactation\u2013associated osteoporosis (PLO) is a rare, severe, early form of osteoporosis in which young women present with fractures, usually multiple vertebral fractures, during late pregnancy or lactation. In studies of idiopathic osteoporosis (IOP) in premenopausal women, we enrolled 78 women with low-trauma fractures and 40 healthy controls, all with normal menses and no secondary cause of bone loss. In 15 of the affected women, the PLO subgroup, fractures had occurred during late pregnancy or lactation. We hypothesized that clinical, bone structural, and metabolic characteristics would differ between women with PLO and those with (non-PLO) IOP and controls. All were evaluated\u2009&amp;gt;\u200912 months postpartum, when structural and remodeling characteristics would be expected to reflect baseline premenopausal status rather than transient postpartum changes. As previously reported, affected subjects (PLO and IOP) had BMD and microarchitectural deficiencies compared to controls. Women with PLO did not differ from those with IOP in terms of age, BMI, body fat, menarcheal age, parity, or age at first pregnancy. However, women with PLO had a more severe clinical presentation than those with IOP: more fractures (5.5\u2009\u00b1\u20093.3 versus 2.6\u2009\u00b1\u20092.1; p\u2009=\u20090.005); more vertebral fractures (80% versus 17%; p\u2009&amp;lt;\u20090.001); and higher prevalence of multiple fractures. BMD deficits were more profound and cortical width tended to be lower in PLO. PLO subjects also had significantly lower tissue-level mineral apposition rate and bone formation rates (0.005\u2009\u00b1\u20090.005 versus 0.011\u2009\u00b1\u20090.010 mm2\/mm\/year; p\u2009=\u20090.006), as well as lower serum P1NP (33\u2009\u00b1\u200912 versus 44\u2009\u00b1\u200918\u2009\u00b5g\/L; p\u2009=\u20090.02) and CTX (257\u2009\u00b1\u2009102 versus 355\u2009\u00b1\u2009193\u2009pg\/mL; p\u2009=\u20090.01) than IOP. The finding that women with PLO have a low bone remodeling state assessed more than a year postpartum increases our understanding of the pathogenic mechanism of PLO. We conclude that women with PLO may have underlying osteoblast functional deficits which could affect their therapeutic response to osteoanabolic medications. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3750","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T13:24:10Z","timestamp":1564147450000},"page":"1552-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Women With Pregnancy and Lactation\u2013Associated Osteoporosis (PLO) Have Low Bone Remodeling Rates at the Tissue Level"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-5747","authenticated-orcid":false,"given":"Adi","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafo","family":"Kamanda-Kosseh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Dempster","sequence":"additional","affiliation":[{"name":"Regional Bone Center, Helen Hayes Hospital West Haverstraw NY USA"},{"name":"Department of Clinical Pathology and Cell Biology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Regional Bone Center, Helen Hayes Hospital West Haverstraw NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Goff","sequence":"additional","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivelisse","family":"Colon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bucovsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Stubby","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Cell Biology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Nickolas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M","family":"Stein","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Hospital for Special Surgery New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Recker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Creighton University school of Medicine Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M","family":"Lappe","sequence":"additional","affiliation":[{"name":"Department of Medicine and College of Nursing Creighton University school of Medicine Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0001","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/00016470510030274","article-title":"Maternity and bone mineral density","volume":"76","author":"Karlsson","year":"2005","journal-title":"Acta Orthop."},{"issue":"10","key":"2024021014441114400_jbmr3750-bib-0002","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s001980170033","article-title":"Pregnancy and lactation confer reversible bone loss in humans","volume":"12","author":"Karlsson","year":"2001","journal-title":"Osteoporos Int."},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0003","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/cs0940405","article-title":"Bone mineral changes during pregnancy and lactation: a longitudinal cohort study","volume":"94","author":"Kolthoff","year":"1998","journal-title":"Clin Sci."},{"issue":"24","key":"2024021014441114400_jbmr3750-bib-0004","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1001\/jama.1993.03500240074029","article-title":"Changes in bone density with lactation","volume":"269","author":"Sowers","year":"1993","journal-title":"JAMA."},{"issue":"7","key":"2024021014441114400_jbmr3750-bib-0005","first-page":"2210","article-title":"Biochemical markers of bone turnover in lactating and nonlactating postpartum women","volume":"80","author":"Sowers","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2024021014441114400_jbmr3750-bib-0006","article-title":"In breastfeeding women, trabecular bone loss at the radius, seen by high resolution peripheral quantitative CT (HRpQCT), persists at 18 months postpartum","volume":"27","author":"Kepley","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"8","key":"2024021014441114400_jbmr3750-bib-0007","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJM199708213370803","article-title":"The effect of calcium supplementation on bone density during lactation and after weaning","volume":"337","author":"Kalkwarf","year":"1997","journal-title":"N Engl J Med"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0008","first-page":"52","article-title":"Bone mineral changes during and after lactation","volume":"94","author":"Polatti","year":"1999","journal-title":"Obstet Gynecol."},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ecl.2016.09.007","article-title":"Premenopausal osteoporosis","volume":"46","author":"Cohen","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"6861","key":"2024021014441114400_jbmr3750-bib-0010","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(55)90214-2","article-title":"Post-pregnancy osteoporosis; a syndrome?","volume":"268","author":"Nordin","year":"1955","journal-title":"Lancet."},{"issue":"9","key":"2024021014441114400_jbmr3750-bib-0011","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00198-015-3149-3","article-title":"Presentation and management of osteoporosis presenting in association with pregnancy or lactation","volume":"26","author":"Kovacs","year":"2015","journal-title":"Osteoporos Int."},{"issue":"7","key":"2024021014441114400_jbmr3750-bib-0012","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s00198-006-0112-3","article-title":"Bisphosphonates in pregnancy and lactation-associated osteoporosis","volume":"17","author":"O\u2019Sullivan","year":"2006","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024021014441114400_jbmr3750-bib-0013","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/rheumatology\/33.3.269","article-title":"Pregnancy-associated osteoporosis: report of two cases with long-term bone density follow-up","volume":"33","author":"Blanch","year":"1994","journal-title":"Br J Rheumatol"},{"issue":"2","key":"2024021014441114400_jbmr3750-bib-0014","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.00027.2015","article-title":"Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery","volume":"96","author":"Kovacs","year":"2016","journal-title":"Physiol Rev."},{"issue":"12","key":"2024021014441114400_jbmr3750-bib-0015","first-page":"865","article-title":"Pregnancy-associated osteoporosis","volume":"88","author":"Smith","year":"1995","journal-title":"QJM."},{"issue":"10","key":"2024021014441114400_jbmr3750-bib-0016","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3109\/09513591003649831","article-title":"Treatment with teriparatide in a patient with pregnancy-associated osteoporosis","volume":"26","author":"Hellmeyer","year":"2010","journal-title":"Gynecol Endocrinol."},{"issue":"5","key":"2024021014441114400_jbmr3750-bib-0017","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00774-011-0334-0","article-title":"Effect of teriparatide on pregnancy and lactation-associated osteoporosis with multiple vertebral fractures","volume":"30","author":"Choe","year":"2012","journal-title":"J Bone Miner Metab"},{"key":"2024021014441114400_jbmr3750-bib-0018","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/TCRM.S30668","article-title":"Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures","volume":"8","author":"Iwamoto","year":"2012","journal-title":"Ther Clin Risk Manag"},{"key":"2024021014441114400_jbmr3750-bib-0019","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2147\/TCRM.S87274","article-title":"A case series of pregnancy- and lactation-associated osteoporosis and a review of the literature","volume":"11","author":"Nakamura","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0020","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2265.1993.tb02398.x","article-title":"Pregnancy associated osteoporosis","volume":"39","author":"Dunne","year":"1993","journal-title":"Clin Endocrinol."},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0021","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00198-017-4239-1","article-title":"Subsequent fracture risk of women with pregnancy and lactation-associated osteoporosis after a median of 6 years of follow-up","volume":"29","author":"Kyvernitakis","year":"2018","journal-title":"Osteoporos Int."},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0022","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00198-014-2852-9","article-title":"Postpartum osteoporosis and vertebral fractures in two patients treated with enoxaparin during pregnancy","volume":"26","author":"Ozdemir","year":"2015","journal-title":"Osteoporos Int."},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0023","doi-asserted-by":"crossref","first-page":"495","DOI":"10.14310\/horm.2002.1383","article-title":"Case report: teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis","volume":"11","author":"Lampropoulou-Adamidou","year":"2012","journal-title":"Hormones (Athens)"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0024","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF00316284","article-title":"Bone mineral density and bone histomorphometric assessments of postpregnancy osteoporosis: a report of five patients","volume":"54","author":"Yamamoto","year":"1994","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2024021014441114400_jbmr3750-bib-0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s001980070113","article-title":"Pregnancy-associated osteoporosis: does the skeleton recover?","volume":"11","author":"Phillips","year":"2000","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024021014441114400_jbmr3750-bib-0026","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00296-011-1816-z","article-title":"Pregnancy-associated spinal osteoporosis treated with bisphosphonates: long-term follow-up of maternal and infants outcome","volume":"32","author":"Vujasinovic-Stupar","year":"2012","journal-title":"Rheumatol Int."},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0027","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jbspin.2003.05.003","article-title":"Pregnancy-associated osteoporosis with vertebral fractures and scoliosis","volume":"71","author":"Sarikaya","year":"2004","journal-title":"Joint Bone Spine"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0028","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jog.12157","article-title":"Pregnancy-associated osteoporosis presenting severe vertebral fractures","volume":"40","author":"Ozturk","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"issue":"2","key":"2024021014441114400_jbmr3750-bib-0029","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00402-013-1912-5","article-title":"Pregnancy-associated osteoporosis with eight fractures in the vertebral column treated with kyphoplasty and bracing: a case report","volume":"134","author":"Bonacker","year":"2014","journal-title":"Arch Orthop Trauma Surg"},{"key":"2024021014441114400_jbmr3750-bib-0030","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1210\/jc.2011-1387","article-title":"Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis","volume":"96","author":"Cohen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2024021014441114400_jbmr3750-bib-0031","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1210\/jc.2009-0996","article-title":"Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis","volume":"94","author":"Cohen","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0032","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00198-011-1560-y","article-title":"Premenopausal women with idiopathic low-trauma fractures and\/or low bone mineral density","volume":"23","author":"Cohen","year":"2012","journal-title":"Osteoporos Int."},{"key":"2024021014441114400_jbmr3750-bib-0033","first-page":"475","volume-title":"Principles and practice of endocrinology and metabolism","author":"Dempster","year":"2002"},{"issue":"3","key":"2024021014441114400_jbmr3750-bib-0034","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1359\/JBMR.051109","article-title":"A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide","volume":"21","author":"Lindsay","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024021014441114400_jbmr3750-bib-0035","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1002\/jbmr.452","article-title":"PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism","volume":"26","author":"Rubin","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0036","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF02509542","article-title":"A microtomographic system for the nondestructive evaluation of bone architecture","volume":"58","author":"Ruegsegger","year":"1996","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2024021014441114400_jbmr3750-bib-0037","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00198-009-0945-7","article-title":"Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy","volume":"21","author":"Cohen","year":"2010","journal-title":"Osteoporos Int."},{"issue":"7","key":"2024021014441114400_jbmr3750-bib-0038","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024021014441114400_jbmr3750-bib-0039","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0221-8747(84)90023-7","article-title":"Osteoporosis associated with pregnancy and lactation: bone biopsy and skeletal features in three patients","volume":"5","author":"Gruber","year":"1984","journal-title":"Metab Bone Dis Relat Res"},{"issue":"2","key":"2024021014441114400_jbmr3750-bib-0041","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archinte.1986.00360140226033","article-title":"Histomorphometric evaluation of reversible heparin-induced osteoporosis in pregnancy","volume":"146","author":"Zimran","year":"1986","journal-title":"Arch Intern Med"},{"issue":"27","key":"2024021014441114400_jbmr3750-bib-0042","first-page":"3865","article-title":"Pregnancy associated osteoporosis","volume":"162","author":"Jensen","year":"2000","journal-title":"Ugeskr Laeger."},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0043","first-page":"261","article-title":"[Heparin osteoporosis : histomorphometric analysis of bone biopsy","volume":"11","author":"Megard","year":"1982","journal-title":"One case (author's transl)]. Nouv Presse Med"},{"issue":"4","key":"2024021014441114400_jbmr3750-bib-0044","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00223-015-0028-z","article-title":"Pregnancy and lactation-associated osteoporosis: bone histomorphometric analysis and response to treatment with zoledronic acid","volume":"97","author":"Grizzo","year":"2015","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"2024021014441114400_jbmr3750-bib-0045","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00198-018-4499-4","article-title":"Mutational analysis uncovers monogenic bone disorders in women with pregnancy-associated osteoporosis: three novel mutations in LRP5, COL1A1, and COL1A2","volume":"29","author":"Butscheidt","year":"2018","journal-title":"Osteoporos Int."},{"issue":"Suppl 1","key":"2024021014441114400_jbmr3750-bib-0046","article-title":"Circulating osteogenic progenitors (COPs) and COP surface IGF-1 receptor density correlate well with bone remodeling on biopsies and change markedly in response to teriparatide (TPTD) in premenopausal women with idiopathic osteoporosis (IOP)","volume":"30","author":"Cohen","year":"2015","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024021014441114400_jbmr3750-bib-0047","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1210\/jc.2013-1172","article-title":"Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study","volume":"98","author":"Cohen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024021014441114400_jbmr3750-bib-0048","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/cen.13557","article-title":"Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis","volume":"88","author":"Hong","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"2024021014441114400_jbmr3750-bib-0049","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1210\/jc.2013-1047","article-title":"Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study","volume":"98","author":"Cohen","year":"2013","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.3750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.3750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/9\/1552\/56655550\/jbmr3750.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/34\/9\/1552\/56655550\/jbmr3750.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:04:08Z","timestamp":1710342248000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/34\/9\/1552-1561\/7605978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,7,26]]},"published-print":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.3750","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,9,1]]},"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"2018-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}