{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:03:31Z","timestamp":1790129011613,"version":"4.0.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T00:00:00Z","timestamp":1298419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bisphosphonates (BPs) are medications used commonly to treat primary and metastatic bone cancer, as well as osteoporosis. Although BPs improve bone mineral density, reduce fracture risk, and reduce hypercalcemia of malignancy, some patients develop BP-related osteonecrosis of the jaws (BRONJ). This devastating complication is defined as clinically exposed bone in the maxillofacial region for more than 8 weeks. Despite an increasing number of BRONJ cases since first reported, the disease pathophysiology remains largely unknown. Since published studies suggest a significant role for dental disease in the pathophysiology of BRONJ, we developed a BRONJ animal model where aggressive periodontal disease is induced by ligature placement around the crown of the right maxillary first molar in the presence of vehicle (veh) or zoledronic acid (ZA), a potent BP. Ligature placement induced significant alveolar bone loss, which was attenuated by ZA treatment. Osteonecrosis was observed associated with ligature-induced periodontitis in the ZA-treated group. This was seen as sequestration and extensive periosteal alveolar bone formation on micro\u2013computed tomography (\u00b5CT) in the ligated site of BP-treated animals. Histologic examination confirmed these findings, seen as necrotic bone with diffuse loss of osteocytes and empty lacunae, rimming of the necrotic bone by squamous epithelium and inflammation, and exposure to the oral cavity. Importantly, the rat lesions were strikingly similar to those of BRONJ patients. Our data suggest that dental disease and potent BP therapy are sufficient for BRONJ development in the rat. \u00a9 2011 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.379","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T22:10:48Z","timestamp":1298671848000},"page":"1871-1882","source":"Crossref","is-referenced-by-count":213,"title":["Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat"],"prefix":"10.1093","volume":"26","author":[{"given":"Tara L","family":"Aghaloo","sequence":"first","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Advanced Prosthodontics, Biomaterials, and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shoff","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ronconi","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack E","family":"Gotcher","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Tennessee Knoxville, Knoxville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Bezouglaia","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Dry","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tetradis","sequence":"additional","affiliation":[{"name":"Molecular Biology Institute, UCLA, Los Angeles, CA, USA"},{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,23]]},"reference":[{"key":"2024020318011037500_bib1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J Bone Miner Res."},{"key":"2024020318011037500_bib2","first-page":"S2","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws: 2009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib3","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib5","first-page":"515","article-title":"Bisphosphonate complications including osteonecrosis of the jaw","volume":"356\u2013360","author":"Mehrotra","year":"2006","journal-title":"Hematology, Am Soc Hematol Educ Program."},{"key":"2024020318011037500_bib6","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","article-title":"Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors","volume":"23","author":"Bamias","year":"2005","journal-title":"J Clin Oncol."},{"key":"2024020318011037500_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib8","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.joms.2003.09.001","article-title":"Avascular necrosis of the jaws: risk factors in metastatic cancer patients","volume":"61","author":"Tarassoff","year":"2003","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib9","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa030897","article-title":"Ten years' experience with alendronate for osteoporosis in postmenopausal women","volume":"350","author":"Bone","year":"2004","journal-title":"N Engl J Med."},{"key":"2024020318011037500_bib10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-2141.2006.06230.x","article-title":"Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: a single-centre experience in 303 patients","volume":"134","author":"Zervas","year":"2006","journal-title":"Br J Haematol."},{"key":"2024020318011037500_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM200507073530120","article-title":"Osteonecrosis of the jaw and bisphosphonates","volume":"353","author":"Durie","year":"2005","journal-title":"N Engl J Med."},{"key":"2024020318011037500_bib12","first-page":"968","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid","volume":"91","author":"Dimopoulos","year":"2006","journal-title":"Haematologica."},{"key":"2024020318011037500_bib13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1359\/jbmr.080205","article-title":"Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates","volume":"23","author":"Hoff","year":"2008","journal-title":"J Bone Miner Res."},{"key":"2024020318011037500_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.eururo.2008.06.070","article-title":"Prevalence and Risk Factors of Bisphosphonate-Associated Osteonecrosis of the Jaw in Prostate Cancer Patients with Advanced Disease Treated with Zoledronate","author":"Walter","year":"2008","journal-title":"Eur Urol."},{"key":"2024020318011037500_bib15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.oraloncology.2007.11.012","article-title":"Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies","volume":"44","author":"Boonyapakorn","year":"2008","journal-title":"Oral Oncol."},{"key":"2024020318011037500_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib18","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1600-051X.2005.00842.x","article-title":"Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment","volume":"32","author":"Ficarra","year":"2005","journal-title":"J Clin Periodontol."},{"key":"2024020318011037500_bib19","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1056\/NEJMp068157","article-title":"Osteonecrosis of the jaw\u2013do bisphosphonates pose a risk?","volume":"355","author":"Bilezikian","year":"2006","journal-title":"N Engl J Med."},{"key":"2024020318011037500_bib20","volume-title":"Oral & Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws","author":"Marx","year":"2007"},{"key":"2024020318011037500_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/annonc\/mdn554","article-title":"Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid","volume":"20","author":"Dimopoulos","year":"2009","journal-title":"Ann Oncol."},{"key":"2024020318011037500_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/annonc\/mdn526","article-title":"Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan","volume":"20","author":"Ripamonti","year":"2009","journal-title":"Ann Oncol."},{"key":"2024020318011037500_bib23","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1200\/JCO.2007.12.1269","article-title":"American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma","volume":"25","author":"Kyle","year":"2007","journal-title":"J Clin Oncol."},{"key":"2024020318011037500_bib24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat's to human's age: how old is my rat in people years?","volume":"21","author":"Quinn","year":"2005","journal-title":"Nutrition."},{"key":"2024020318011037500_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1902\/jop.2007.060321","article-title":"Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis","volume":"78","author":"Rogers","year":"2007","journal-title":"J Periodontol."},{"key":"2024020318011037500_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tripleo.2007.01.040","article-title":"Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer","volume":"104","author":"Bianchi","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"2024020318011037500_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tripleo.2007.08.040","article-title":"Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology","volume":"105","author":"Bedogni","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"2024020318011037500_bib28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2353\/ajpath.2010.090592","article-title":"Bisphosphonates cause osteonecrosis of the jaw-like disease in mice","volume":"177","author":"Bi","year":"2010","journal-title":"Am J Pathol."},{"key":"2024020318011037500_bib29","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1200\/JCO.2005.06.091","article-title":"Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid","volume":"23","author":"Coleman","year":"2005","journal-title":"J Clin Oncol."},{"key":"2024020318011037500_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcp042806","article-title":"Clinical practice. Hypercalcemia associated with cancer","volume":"352","author":"Stewart","year":"2005","journal-title":"N Engl J Med."},{"key":"2024020318011037500_bib31","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/sj.bjc.6603740","article-title":"Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer","volume":"96","author":"Duivenvoorden","year":"2007","journal-title":"Br J Cancer."},{"key":"2024020318011037500_bib32","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.ejca.2004.03.025","article-title":"Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer","volume":"40","author":"Diel","year":"2004","journal-title":"Eur J Cancer."},{"key":"2024020318011037500_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.blo.0000132404.30139.f2","article-title":"Osteoporosis: a review","volume":"425","author":"Lin","year":"2004","journal-title":"Clin Orthop Relat Res."},{"key":"2024020318011037500_bib34","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int."},{"key":"2024020318011037500_bib35","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.2174\/138161207782110435","article-title":"Expression of defensins in gingiva and their role in periodontal health and disease","volume":"13","author":"Chung","year":"2007","journal-title":"Curr Pharm Des."},{"key":"2024020318011037500_bib36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nri1857","article-title":"The scientific and public-health imperative for a vaccine against dental caries","volume":"6","author":"Taubman","year":"2006","journal-title":"Nat Rev Immunol."},{"key":"2024020318011037500_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1752-7325.1999.tb03237.x","article-title":"Plausibility of periodontal disease estimates from NHANES III","volume":"59","author":"Slade","year":"1999","journal-title":"J Public Health Dent."},{"issue":"(5 Suppl)","key":"2024020318011037500_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib39","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.joms.2008.01.038","article-title":"Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment","volume":"66","author":"Allen","year":"2008","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1601-6343.2009.01456.x","article-title":"Mandibular necrosis in beagle dogs treated with bisphosphonates","volume":"12","author":"Burr","year":"2009","journal-title":"Orthod Craniofac Res."},{"key":"2024020318011037500_bib41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.oraloncology.2008.04.013","article-title":"Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol."},{"key":"2024020318011037500_bib42","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jbmr.37","article-title":"Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice","volume":"25","author":"Kikuiri","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020318011037500_bib43","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jbmr.23","article-title":"Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats","volume":"25","author":"Hokugo","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020318011037500_bib44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-0765.1981.tb00995.x","article-title":"The progress of the periodontal syndrome in the rice cat. II. The effects of a diphosphonate on the periodontium","volume":"16","author":"Gotcher","year":"1981","journal-title":"J Periodontal Res."},{"key":"2024020318011037500_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-0765.1981.tb00976.x","article-title":"The progress of the periodontal syndrome in the rice rat. I. Morphometric and autoradiographic studies","volume":"16","author":"Gotcher","year":"1981","journal-title":"J Periodontal Res."},{"key":"2024020318011037500_bib46","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/j.0022-0337.2002.66.12.tb03612.x","article-title":"Bone scintigraphy as an adjunct for the diagnosis of oral diseases","volume":"66","author":"Ferreira","year":"2002","journal-title":"J Dent Educ."},{"key":"2024020318011037500_bib47","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00006231-200403000-00015","article-title":"Dental diseases and radionuclide imaging of the jaws","volume":"25","author":"Arias","year":"2004","journal-title":"Nucl Med Commun."},{"key":"2024020318011037500_bib48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00003072-197912000-00005","article-title":"Dental lesions causing abnormalities on skeletal scintigraphy","volume":"4","author":"Lyons","year":"1979","journal-title":"Clin Nucl Med."},{"key":"2024020318011037500_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/0030-4220(89)90243-0","article-title":"The relationship between radionuclide bone scans and dental examinations","volume":"68","author":"Strittmatter","year":"1989","journal-title":"Oral Surg Oral Med Oral Pathol."},{"key":"2024020318011037500_bib50","first-page":"845","article-title":"Bone scan in dental diseases","volume":"19","author":"Tow","year":"1978","journal-title":"J Nucl Med."},{"key":"2024020318011037500_bib51","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1902\/jop.2007.060214","article-title":"Influence of photodynamic therapy on the development of ligature-induced periodontitis in rats","volume":"78","author":"de Almeida","year":"2007","journal-title":"J Periodontol."},{"key":"2024020318011037500_bib52","first-page":"3","article-title":"Bisphosphonates in periodontal treatment: a review","volume":"7","author":"Badran","year":"2009","journal-title":"Oral Health Prev Dent."},{"key":"2024020318011037500_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00223-006-0031-5","article-title":"Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib","volume":"79","author":"Allen","year":"2006","journal-title":"Calcif Tissue Int."},{"key":"2024020318011037500_bib54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bone.2009.10.023","article-title":"Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading","volume":"46","author":"Feher","journal-title":"Bone."},{"key":"2024020318011037500_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00774-007-0782-8","article-title":"Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats","volume":"26","author":"Kashii","year":"2008","journal-title":"J Bone Miner Metab."},{"key":"2024020318011037500_bib56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1034\/j.1600-0765.2003.00694.x","article-title":"Proteases augment the effects of lipopolysaccharide in rat gingiva","volume":"38","author":"Ekuni","year":"2003","journal-title":"J Periodontal Res."},{"key":"2024020318011037500_bib57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tripleo.2005.06.022","article-title":"Mandibular osteomyelitis and tooth exfoliation following zoster-CMV co-infection","volume":"101","author":"Meer","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"2024020318011037500_bib58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1834-7819.2003.tb00011.x","article-title":"Oral ulceration with bone sequestration","volume":"48","author":"Farah","year":"2003","journal-title":"Aust Dent J."},{"key":"2024020318011037500_bib59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hed.2890040313","article-title":"Osteonecrosis of the jaws: a complication of cancer chemotherapy","volume":"4","author":"Schwartz","year":"1982","journal-title":"Head Neck Surg."},{"key":"2024020318011037500_bib60","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joms.2008.02.012","article-title":"Nonexposed bisphosphonate-related osteonecrosis of the jaws: another clinical variant?","volume":"66","author":"Junquera","year":"2008","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib61","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joms.2009.10.010","article-title":"Osteonecrosis of the jaw in a patient on Denosumab","volume":"68","author":"Aghaloo","journal-title":"J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bjoms.2009.08.030","article-title":"Osteonecrosis of the jaws induced by anti-RANK ligand therapy","volume":"48","author":"Taylor","year":"2010","journal-title":"Br J Oral Maxillofac Surg."},{"key":"2024020318011037500_bib63","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00198-010-1177-6","article-title":"Denosumab-related osteonecrosis of the jaws","volume":"22","author":"Kyrgidis","year":"2011","journal-title":"Osteoporosis Int."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/8\/1871\/56557851\/379_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/8\/1871\/56557851\/379_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:04:15Z","timestamp":1710327855000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/26\/8\/1871-1882\/7597938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,23]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,2,23]]},"published-print":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.379","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,8,1]]},"published":{"date-parts":[[2011,2,23]]}}}