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Current research has been largely focused on the distribution and function of specific neuronal populations within bone, as well as their cellular and molecular relationships with target cells in the bone microenvironment. This review provides a historical perspective of the field of skeletal neurobiology that highlights the diverse yet interconnected nature of nerves and skeletal health, particularly in the context of bone anabolism and pain. We explore what is known regarding the neuronal subtypes found in the skeleton, their distribution within bone compartments, and their central projection pathways. This neuroskeletal map then serves as a foundation for a comprehensive discussion of the neural control of skeletal development, homeostasis, repair, and bone pain. Active synthesis of this research recently led to the first biotherapeutic success story in the field. Specifically, the ongoing clinical trials of anti\u2010nerve growth factor therapeutics have been optimized to titrated doses that effectively alleviate pain while maintaining bone and joint health. Continued collaborations between neuroscientists and bone biologists are needed to build on this progress, leading to a more complete understanding of neural regulation of the skeleton and development of novel therapeutics. \u00a9 2019 The Authors.\n                    <jats:italic>Journal of Bone and Mineral Research<\/jats:italic>\n                    published by Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jbmr.3822","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T13:19:36Z","timestamp":1561641576000},"page":"1393-1406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":210,"title":["Nerves in Bone: Evolving Concepts in Pain and Anabolism"],"prefix":"10.1093","volume":"34","author":[{"given":"Jennifer M","family":"Brazill","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Bone and Mineral Diseases Washington University  St. 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