{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:27Z","timestamp":1786977987473,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although a relationship between vascular disease and osteoporosis has been recognized, its clinical importance for fracture risk evaluation remains uncertain. Abdominal aortic calcification (AAC), a recognized measure of vascular disease detected on single-energy images performed for vertebral fracture assessment, may also identify increased osteoporosis risk. In a prospective 10-year study of 1024 older predominantly white women (mean age 75.0 \u00b1 2.6 years) from the Perth Longitudinal Study of Aging cohort, we evaluated the association between AAC, skeletal structure, and fractures. AAC and spine fracture were assessed at the time of hip densitometry and heel quantitative ultrasound. AAC was scored 0 to 24 (AAC24) and categorized into low AAC (score 0 and 1, n = 459), moderate AAC (score 2 to 5, n = 373), and severe AAC (score text-decoration:underline6, n = 192). Prevalent vertebral fractures were calculated using the Genant semiquantitative method. AAC24 scores were inversely related to hip BMD ( rs = \u20130.077, p = 0.013), heel broadband ultrasound attenuation ( rs = \u20130.074, p = 0.020), and the Stiffness Index ( rs = \u20130.073, p = 0.022). In cross-sectional analyses, women with moderate to severe AAC were more likely to have prevalent fracture and lumbar spine imaging-detected lumbar spine fractures, but not thoracic spine fractures (Mantel-Haenszel test of trend p &amp;lt; 0.05). For 10-year incident clinical fractures and fracture-related hospitalizations, women with moderate to severe AAC (AAC24 score &amp;gt;1) had increased fracture risk (HR 1.48; 95% CI, 1.15 to 1.91; p = 0.002; HR 1.46; 95% CI, 1.07 to 1.99; p = 0.019, respectively) compared with women with low AAC. This relationship remained significant after adjusting for age and hip BMD for clinical fractures (HR 1.40; 95% CI, 1.08 to 1.81; p = 0.010), but was attenuated for fracture-related hospitalizations (HR 1.33; 95% CI, 0.98 to 1.83; p = 0.073). In conclusion, older women with more marked AAC are at higher risk of fracture, not completely captured by bone structural predictors. These findings further support the concept that vascular calcification and bone pathology may share similar mechanisms of causation that remain to be fully elucidated \u00a9 2019 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.3830","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T10:01:36Z","timestamp":1563271296000},"page":"2052-2060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Association Between Abdominal Aortic Calcification, Bone Mineral Density, and Fracture in Older Women"],"prefix":"10.1093","volume":"34","author":[{"given":"Joshua R","family":"Lewis","sequence":"first","affiliation":[{"name":"Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney NSW Australia"},{"name":"Medical School, The University of Western Australia Perth WA Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste J","family":"Eggermont","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Schousboe","sequence":"additional","affiliation":[{"name":"Park Nicollet Osteoporosis Center and HealthPartners Institute, Minneapolis, MN, USA, and Division of Health Policy and Management, University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai H","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital Perth WA Australia"},{"name":"Medical School, The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Khoo","sequence":"additional","affiliation":[{"name":"School of Physics, University of Western Australia, Nedlands WA Australia"},{"name":"Medical Technology and Physics, Sir Charles Gairdner Hospital, Nedlands WA Australia"},{"name":"Medical School, The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sim","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia Perth WA Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MingXiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Metabolism, Shanghai Zhongshan Hospital, Fudan University Shanghai China"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Oslo Oslo Norway"},{"name":"Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia Perth WA Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital Perth WA Australia"},{"name":"Medical School, The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E","family":"Wilson","sequence":"additional","affiliation":[{"name":"Skeletal Health, Hologic, Inc. 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