{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:43:10Z","timestamp":1791430990645,"version":"4.3.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JO & JR Wicking Trust"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multicomponent exercise programs are recommended to reduce fracture risk; however, their effectiveness in real-world community settings remain uncertain. This 18-month randomized controlled trial investigated the effects of a 12-month, community-based, supervised multicomponent exercise program followed by a 6-month \u201cresearch-to-practice\u201d transition on areal bone mineral density (BMD), trabecular bone microarchitecture, functional performance, and falls in older adults at increased fracture risk. One-hundred and sixty-two adults aged \u226560\u2009years with osteopenia or at increased falls risk were randomized to the Osteo-cise: Strong Bones for Life multicomponent exercise program (n = 81) or a control group (n = 81). Exercise consisted of progressive resistance, weight-bearing impact, and balance training (3-days\/week) performed at community leisure centers. Overall 148 (91%) participants completed the trial, and mean exercise adherence was 59% after 12 months and 45% during the final 6 months. After 12\u2009months, there were significant net beneficial effects of exercise on lumbar spine and femoral neck BMD (1.0% to 1.1%, p\u2009&amp;lt;\u20090.05), muscle strength (10% to 13%, p\u2009&amp;lt;\u20090.05), and physical function (timed stair climb 5%; four-square step test 6%; sit-to-stand 16%, p ranging &amp;lt;0.05 to &amp;lt;0.001), which persisted after the 6-month transition. There were no significant effects of the 18-month intervention on distal femur or proximal tibia trabecular bone microarchitecture or falls incidence, but per protocol analysis (\u226566% exercise adherence) revealed there was a significant net benefit of exercise (mean [95% confidence interval] 2.8% [0.2, 5,4]) on proximal tibia trabecular bone volume fraction (Osteo-cise 1.5% [\u22121.2, 4.2]; controls \u22121.3% [\u22122.6, 0.1]) after 18 months due to changes in trabecular number (Osteo-cise 1.7% [\u22120.9, 4.3]; controls \u22121.1% [\u22122.4, 0.2]) but not trabecular thickness (Osteo-cise\u2009\u2212\u20090.2% [\u22120.5, 0.2]; controls \u22120.2% [\u22120.4, 0.0]). In conclusion, this study supports the effectiveness of the Osteo-cise: Strong Bones for Life program as a real-world, pragmatic, evidence-based community exercise program to improve multiple musculoskeletal health outcomes in older adults at increased fracture risk. \u00a9 2019 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3865","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T12:28:04Z","timestamp":1568032084000},"page":"419-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Effects of a 12-Month Supervised, Community-Based, Multimodal Exercise Program Followed by a 6-Month Research-to-Practice Transition on Bone Mineral Density, Trabecular Microarchitecture, and Physical Function in Older Adults: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-1598","authenticated-orcid":false,"given":"Robin M","family":"Daly","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Gianoudis","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-3577","authenticated-orcid":false,"given":"Mariana E","family":"Kersh","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-3742","authenticated-orcid":false,"given":"Peter R","family":"Ebeling","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Sciences at Monash Health Monash University Melbourne Australia"},{"name":"Department of Medicine The University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Krug","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, School of Medicine University of California, San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryl A","family":"Nowson","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Hill","sequence":"additional","affiliation":[{"name":"School of Physiotherapy and Exercise Science Curtin University Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-6592","authenticated-orcid":false,"given":"Kerrie M","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"issue":"5","key":"2024031419003261300_jbmr3865-bib-0001","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1210\/jc.2019-00192","article-title":"Efficacy of pharmacological therapies for the prevention of fractures in postmenopausal women: a network meta-analysis","volume":"104","author":"Barrionuevo","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2024031419003261300_jbmr3865-bib-0002","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1210\/jc.2011-3060","article-title":"Clinical review. 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