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Therefore, we examined risk of fracture at seven different sites associated with seven different types of physical activity in the population-based prospective UK Million Women Study. A total of 371,279 postmenopausal women (mean age 59.8\u2009years), rating their health as good or excellent and reporting participation in walking, cycling, gardening, doing housework, yoga, dance, and sports club activities, were followed for site-specific incident fracture through record linkage to national databases on day-case and overnight hospital admissions. Cox regression yielded adjusted relative risks (RRs) and, because of the large number of statistical tests done, 99% confidence intervals (CIs) for fracture at seven different sites in relation to seven different physical activities. During an average follow-up of 12\u2009years, numbers with a first site-specific fracture were as follows: humerus (2341), forearm (1238), wrist (7358), hip (4354), femur (not neck) (617), lower leg (1184), and ankle (3629). For upper limb fractures there was significant heterogeneity across the seven activity types (test for heterogeneity p = 0.004), with gardening more than 1 hour\/week associated with a lower risk (RR = 0.91; 99% CI, 0.86 to 0.96; p\u2009&amp;lt;\u20090.0001), whereas cycling more than 1 hour\/week was associated with an increased risk (RR = 1.11; 99% CI, 1.00 to 1.23; p = 0.008). For fractures of the lower limb (including hip) there was no significant heterogeneity by type of activity, with significant approximately 5% to 15% reductions in risk associated with most activities, except cycling. For hip fractures, there was no significant heterogeneity by type of activity, but with significant 15% to 20% reductions in risk associated with walking for 1\u2009hour\/day and participating in yoga and sporting activities. Physical activity is a modifiable risk factor for fracture, but the effects differ between different types of activities and different fracture sites. \u00a9 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3896","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:34:15Z","timestamp":1571265255000},"page":"277-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Associations Between Seven Different Types of Physical Activity and the Incidence of Fracture at Seven Sites in Healthy Postmenopausal UK Women"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-5776","authenticated-orcid":false,"given":"Miranda EG","family":"Armstrong","sequence":"first","affiliation":[{"name":"School for Policy Studies, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-907X","authenticated-orcid":false,"given":"Clare J","family":"Wotton","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Cairns","sequence":"additional","affiliation":[{"name":"MRC Population Health Research Unit, Nuffield Department of Population Health University of Oxford Oxford UK"},{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Green","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Floud","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Beral","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian K","family":"Reeves","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Million Women Study Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"issue":"1","key":"2024031418584942600_jbmr3896-bib-0001","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3111\/13696998.2010.547967","article-title":"Study of the incremental cost and clinical burden of hip fractures in postmenopausal women in the United Kingdom","volume":"14","author":"Guti\u00e9rrez","year":"2011","journal-title":"J Med Econ"},{"issue":"6","key":"2024031418584942600_jbmr3896-bib-0002","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.bone.2012.03.014","article-title":"Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women","volume":"50","author":"Armstrong","year":"2012","journal-title":"Bone"},{"issue":"6","key":"2024031418584942600_jbmr3896-bib-0003","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/jbmr.315","article-title":"Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women","volume":"26","author":"Armstrong","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024031418584942600_jbmr3896-bib-0004","first-page":"1802","article-title":"Risk factors for hip fracture in European women: the MEDOS Study. 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