{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:10:48Z","timestamp":1792987848859,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study was conducted to examine the association between renal function and hip fracture. We followed up 352,624 Korean adults, who participated in health examinations during 2009\u20132010 until 2013. Kidney function was assessed by creatinine-based estimated glomerular filtration rate (eGFR) and albuminuria using urine reagent strip results. The incidence of hip fracture was examined by hospital discharge records. Hazard ratios (HRs) for hip fracture were calculated using Cox proportional hazard models after adjusting for multiple confounders. During a mean follow-up of 4.0\u2009years, 1177 participants suffered a hip fracture. Lower eGFR and more severe albuminuria were associated with a higher risk of hip fracture. The HRs for hip fracture were 1.89 (95% confidence interval [CI] 1.47\u20132.43) and 3.75 (95% CI 2.30\u20136.11) among participants with eGFRs of 30 to 44 and 15 to 29\u2009mL\/min\/1.73m2 relative to those with an eGFR \u226560\u2009mL\/min\/1.73m2, respectively. The HRs were 1.30 (95% CI 1.02\u20131.65) for moderate albuminuria and 1.58 (95% CI 1.07\u20132.35) for severe albuminuria (p for trend = 0.002). Participants with albuminuria had a higher risk of hip fracture than those without albuminuria, even when they belonged to the same eGFR category (HR = 1.75 versus 3.30 for an eGFR of 30 to 44\u2009mL\/min\/1.73m2; HR = 2.72 versus 7.84 for an eGFR of 15 to 29\u2009mL\/min\/1.73m2). The effects of each 10\u2009mL\/min\/1.73m2 decrease in eGFR were stronger with advancing albuminuria severity (pinteraction = 0.016). In conclusion, both low eGFR and albuminuria were risk factors for incident hip fracture in Korean adults. Moreover, these factors exerted a synergistic effect on the risk of hip fracture. \u00a9 2020 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.3997","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T14:32:26Z","timestamp":1583159546000},"page":"1313-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chronic Kidney Disease Increases the Risk of Hip Fracture: A Prospective Cohort Study in Korean Adults"],"prefix":"10.1093","volume":"35","author":[{"given":"Se Hwa","family":"Kim","sequence":"first","affiliation":[{"name":"Institute for Clinical and Translational Research Catholic Kwandong University College of Medicine Gangneung Republic of Korea"},{"name":"Department of Internal Medicine International St. Mary's Hospital, Catholic Kwandong University College of Medicine Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-6205","authenticated-orcid":false,"given":"Sang-Wook","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Catholic Kwandong University College of Medicine Gangneung Republic of Korea"},{"name":"Institute for Clinical and Translational Research Catholic Kwandong University College of Medicine Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Jeon","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute for Occupational and Environmental Health Catholic Kwandong University Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research Catholic Kwandong University College of Medicine Gangneung Republic of Korea"},{"name":"Department of Internal Medicine International St. Mary's Hospital, Catholic Kwandong University College of Medicine Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jun","family":"Won","sequence":"additional","affiliation":[{"name":"Institute for Bio-Medical Convergence Catholic Kwandong University College of Medicine Gangneung Republic of Korea"},{"name":"Department of Internal Medicine International St. Mary's Hospital, Catholic Kwandong University College of Medicine Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"issue":"6","key":"2024031418594886100_jbmr3997-bib-0001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7326\/0003-4819-152-6-201003160-00008","article-title":"Meta-analysis: excess mortality after hip fracture among older women and 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