{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:55:55Z","timestamp":1789642555215,"version":"4.0.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T00:00:00Z","timestamp":1302652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disuse osteoporosis in children is a progressive disease that can affect quality of life. High-frequency, low-magnitude vibration (HFLMV) acts as an anabolic signal for bone and muscle. We undertook a prospective, randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of regional HFLMV in disabled children. Sixty-five children 6 to 9 year of age were randomized into three groups: placebo, 60\u2009Hz, and 90\u2009Hz. In the two active groups, a 0.3-g mechanical vibration was delivered to the radii and femurs for 5\u2009minutes each day. After 6 months, the main endpoint was bone mineral density (BMD) at the ultradistal radius (UDR), 33% radii (33%R), and femoral necks (FN). Secondary endpoints were area and bone mineral content (BMC) at the UDR, 33%R, and FN; grip force of the upper and lower limbs; motor function; and PedsQL evaluation. An intention-to-treat analysis was used. Fifty-seven children (88%) completed the protocol. A significant increase was observed in the 60-Hz group relative to the other groups in BMD at the UDR (p\u2009=\u2009.011), in grip force of the upper limbs (p\u2009=\u2009.035), and in the \u201cdaily activities item\u201d (p\u2009=\u2009.035). A mixed model to evaluate the response to intervention showed a stronger effect of 60\u2009Hz on patients with cerebral palsy on the UDR and that between-subject variability significantly affected the response. There were no reported side effects of the intervention. This work provides evidence that regional HFLMV is an effective and safe strategy to improve bone mass, muscle strength, and possibly independence in children with motor disabilities. \u00a9 2011 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.402","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:20:41Z","timestamp":1302740441000},"page":"1759-1766","source":"Crossref","is-referenced-by-count":64,"title":["High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children"],"prefix":"10.1093","volume":"26","author":[{"given":"M Loreto","family":"Reyes","sequence":"first","affiliation":[{"name":"Endocrine Unit, Pediatrics Department, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Neurology Unit, Pediatrics Department, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz J","family":"Holmgren","sequence":"additional","affiliation":[{"name":"Teleton Institute of Rehabilitation, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Sanhueza","sequence":"additional","affiliation":[{"name":"Research and Projects Division, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal G","family":"Escobar","sequence":"additional","affiliation":[{"name":"Neurorehabilitation and Neuromuscular Diseases Unit, Pediatrics Department, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,13]]},"reference":[{"key":"2024020318015891100_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1359\/JBMR.0301245","article-title":"Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study","volume":"19","author":"Verschueren","year":"2004","journal-title":"J Bone Miner Res."},{"key":"2024020318015891100_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1359\/JBMR.0301251","article-title":"Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trail assessing compliance, efficacy, and safety","volume":"19","author":"Rubin","year":"2004","journal-title":"J Bone Miner 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