{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:23:24Z","timestamp":1791566604372,"version":"4.3.4"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":1435,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia\/osteoporosis in men has still to be confirmed. To evaluate the effect of low-volume\/high-intensity (HIT)-DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty-three sedentary community-dwelling older men (aged 73 to 91\u2009years) with osteopenia\/osteoporosis and SMI-based sarcopenia were randomly assigned to a HIT-RT exercise group (EG; n =\u200921) or a control group (CG; n =\u200922). HIT-RT provided a progressive, periodized single-set DRT on machines with high intensity, effort, and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, vitamin D, and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was SMI as determined by dual-energy X-ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip\u2212\/leg-extensor strength (leg press). After 12\u2009months of exercise, LS-BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between-group differences (p &amp;lt;\u20090.001; standardized mean difference [SMD] =\u20090.90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p &amp;lt;\u20090.001; SMD = 1.95). Total hip BMD changes did not differ significantly between the groups (p =\u20090.064; SMD = 0.65), whereas changes in maximum hip\u2212\/leg-extensor strength were much more prominent (p &amp;lt;\u20090.001; SMD = 1.92) in the EG. Considering dropout (n =\u20092), attendance rate (95%), and unintended side effects\/injuries (n =\u20090), we believe our HIT-RT protocol to be feasible, attractive, and safe. In summary, we conclude that our combined low-threshold HIT-RT\/protein\/vitamin D\/calcium intervention was feasible, safe, and effective for tackling sarcopenia and osteopenia\/osteoporosis in older men with osteosarcopenia. \u00a9 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.4027","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T08:26:28Z","timestamp":1586420788000},"page":"1634-1644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia\u2014One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-0669","authenticated-orcid":false,"given":"Wolfgang","family":"Kemmler","sequence":"first","affiliation":[{"name":"Institute of Medical Physics Friedrich-Alexander University of Erlangen-N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kohl","sequence":"additional","affiliation":[{"name":"Faculty Medical and Life Sciences University of Furtwangen Villingen-Schwenningen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Department of Sports Science University of Kaiserslautern Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-8437","authenticated-orcid":false,"given":"Franz","family":"Jakob","sequence":"additional","affiliation":[{"name":"Bernhard-Heine-Center for Locomotion Research W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-4123","authenticated-orcid":false,"given":"Klaus","family":"Engelke","sequence":"additional","affiliation":[{"name":"Department of Medicine III Friedrich-Alexander University of Erlangen-N\u00fcrnberg, University Hospital Erlangen Erlangen Germany"},{"name":"Institute of Medical Physics Friedrich-Alexander University of Erlangen-N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"von Stengel","sequence":"additional","affiliation":[{"name":"Institute of Medical Physics Friedrich-Alexander University of Erlangen-N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schoene","sequence":"additional","affiliation":[{"name":"Institute of Medical Physics Friedrich-Alexander University of Erlangen-N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"issue":"7","key":"2024031419593408800_jbmr4027-bib-0001","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jbmr.1969","article-title":"Bone and skeletal muscle: neighbors with close ties","volume":"28","author":"DiGirolamo","year":"2013","journal-title":"J Bone Miner Res."},{"key":"2024031419593408800_jbmr4027-bib-0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2015.10.017","article-title":"Muscle-bone interactions: from experimental models to the clinic? 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Effekte auf K\u00f6rperzusammensetzung und Muskelkraft","volume":"66","author":"Kemmler","year":"2015","journal-title":"Dtsch Z Sportmed."},{"issue":"1","key":"2024031419593408800_jbmr4027-bib-0023","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1519\/JSC.0000000000001049","article-title":"Novel resistance training-specific rating of perceived exertion scale measuring repetitions in reserve","volume":"30","author":"Zourdos","year":"2016","journal-title":"J Strength Cond Res."},{"issue":"4","key":"2024031419593408800_jbmr4027-bib-0024","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bone.2008.11.008","article-title":"Reanalysis precision of 3D quantitative computed tomography (QCT) of the spine","volume":"44","author":"Engelke","year":"2009","journal-title":"Bone."},{"issue":"2","key":"2024031419593408800_jbmr4027-bib-0025","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/s-2007-1024673","article-title":"Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females","volume":"12","author":"Kraemer","year":"1991","journal-title":"Int J Sports Med."},{"issue":"10","key":"2024031419593408800_jbmr4027-bib-0026","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1001\/archinte.164.10.1084","article-title":"Benefits of 2\u2009years of intense exercise on bone density, physical fitness, and blood lipids in early postmenopausal osteopenic women: results of the Erlangen fitness osteoporosis prevention study (EFOPS)","volume":"164","author":"Kemmler","year":"2004","journal-title":"Arch Intern Med."},{"issue":"3","key":"2024031419593408800_jbmr4027-bib-0027","first-page":"325","article-title":"The effect of habitual physical activity, non-athletic exercise, muscle strength, and VO2max on bone mineral density is rather low in early postmenopausal osteopenic women","volume":"4","author":"Kemmler","year":"2004","journal-title":"J Musculoskelet Neuronal Interact."},{"issue":"7","key":"2024031419593408800_jbmr4027-bib-0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v045.i07","article-title":"Amelia II: a program for missing data","volume":"45","author":"Honaker","year":"2011","journal-title":"J Stat Soft."},{"key":"2024031419593408800_jbmr4027-bib-0029","first-page":"8","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988","edition":"2nd ed"},{"issue":"12","key":"2024031419593408800_jbmr4027-bib-0030","doi-asserted-by":"crossref","first-page":"e15941","DOI":"10.1371\/journal.pone.0015941","article-title":"Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions","volume":"5","author":"Schafer","year":"2010","journal-title":"PLoS One."},{"issue":"7","key":"2024031419593408800_jbmr4027-bib-0031","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/gerona\/60.7.901","article-title":"Measuring disability and function in older women: psychometric properties of the late-life function and disability instrument","volume":"60","author":"McAuley","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"1","key":"2024031419593408800_jbmr4027-bib-0032","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jocd.2007.12.010","article-title":"Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions","volume":"11","author":"Engelke","year":"2008","journal-title":"J Clin Densitom."},{"issue":"4","key":"2024031419593408800_jbmr4027-bib-0033","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1210\/jc.2010-2284","article-title":"Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial","volume":"96","author":"Kukuljan","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2024031419593408800_jbmr4027-bib-0034","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1519\/00139143-200708000-00007","article-title":"Effect of weighted exercises on bone mineral density in post menopausal women. 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optimize resistance exercise training for older adults with age-related muscle atrophy","volume":"99","author":"Stec","year":"2017","journal-title":"Exp Gerontol."},{"issue":"8","key":"2024031419593408800_jbmr4027-bib-0045","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1249\/mss.0b013e318060111f","article-title":"The impact of resistance exercise on the cognitive function of the elderly","volume":"39","author":"Cassilhas","year":"2007","journal-title":"Med Sci Sports Exerc."},{"issue":"7","key":"2024031419593408800_jbmr4027-bib-0046","doi-asserted-by":"crossref","first-page":"e014619","DOI":"10.1136\/bmjopen-2016-014619","article-title":"The effect of combined resistance exercise training and vitamin D3 supplementation on musculoskeletal health and function in older adults: a systematic review and meta-analysis","volume":"7","author":"Antoniak","year":"2017","journal-title":"BMJ Open."},{"issue":"9","key":"2024031419593408800_jbmr4027-bib-0047","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/sms.12536","article-title":"Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: a meta-analysis","volume":"26","author":"Csapo","year":"2016","journal-title":"Scand J Med Sci Sports."},{"issue":"2","key":"2024031419593408800_jbmr4027-bib-0048","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s40279-014-0269-4","article-title":"Effects of protein supplementation in older adults undergoing resistance training: a systematic review and meta-analysis","volume":"45","author":"Finger","year":"2015","journal-title":"Sports Med."},{"issue":"4","key":"2024031419593408800_jbmr4027-bib-0049","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3945\/ajcn.116.143594","article-title":"Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis","volume":"106","author":"Liao","year":"2017","journal-title":"Am J Clin Nutr."},{"issue":"4","key":"2024031419593408800_jbmr4027-bib-0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev Endocr Metab Disord."},{"issue":"2","key":"2024031419593408800_jbmr4027-bib-0051","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1249\/MSS.0b013e3181eb6265","article-title":"Influence of resistance exercise on lean body mass in aging adults: a meta-analysis","volume":"43","author":"Peterson","year":"2011","journal-title":"Med Sci Sports Exerc."},{"issue":"4","key":"2024031419593408800_jbmr4027-bib-0052","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.amepre.2010.06.006","article-title":"Trend and prevalence estimates based on the 2008 physical activity guidelines 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