{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:46:08Z","timestamp":1787895968888,"version":"build-2784847793"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":1362,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"am","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["AR075013"],"award-info":[{"award-number":["AR075013"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["PR180268P1"],"award-info":[{"award-number":["PR180268P1"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"US Department of Energy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["AR075013"],"award-info":[{"award-number":["AR075013"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["PR180268P1"],"award-info":[{"award-number":["PR180268P1"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post-traumatic osteoarthritis (PTOA) is an injury-induced type of OA that persists in an asymptomatic phase for years before it becomes diagnosed in ~50% of injured individuals. Although PTOA is not classified as an inflammatory disease, it has been suggested that inflammation could be a major driver of PTOA development. Here we examined whether a state of systemic inflammation induced by lipopolysaccharide (LPS) administration 5-days before injury would modulate PTOA outcomes. RNA-seq analysis at 1-day post-injury followed by micro-computed tomography (\u03bcCT) and histology characterization at 6\u2009weeks post-injury revealed that LPS administration causes more severe PTOA phenotypes. These phenotypes included significantly higher loss of cartilage and subchondral bone volume. Gene expression analysis showed that LPS alone induced a large cohort of inflammatory genes previously shown to be elevated in synovial M1 macrophages of rheumatoid arthritis (RA) patients, suggesting that systemic LPS produces synovitis. This synovitis was sufficient to promote PTOA in MRL\/MpJ mice, a strain previously shown to be resistant to PTOA. The synovium of LPS-treated injured joints displayed an increase in cellularity, and immunohistological examination confirmed that this increase was in part attributable to an elevation in type 1 macrophages. LPS induced the expression of Tlr7 and Tlr8 in both injured and uninjured joints, genes known to be elevated in RA. We conclude that inflammation before injury is an important risk factor for the development of PTOA and that correlating patient serum endotoxin levels or their state of systemic inflammation with PTOA progression may help develop new, effective treatments to lower the rate of PTOA in injured individuals. \u00a9 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.4117","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T07:26:00Z","timestamp":1592724360000},"page":"2229-2241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["LPS-Induced Inflammation Prior to Injury Exacerbates the Development of Post-Traumatic Osteoarthritis in Mice"],"prefix":"10.1093","volume":"35","author":[{"given":"Melanie E","family":"Mendez","sequence":"first","affiliation":[{"name":"School of Natural Sciences University of California Merced Merced CA USA"},{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimy","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa K","family":"Murugesh","sequence":"additional","affiliation":[{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R","family":"Hum","sequence":"additional","affiliation":[{"name":"School of Natural Sciences University of California Merced Merced CA USA"},{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L","family":"McCool","sequence":"additional","affiliation":[{"name":"School of Natural Sciences University of California Merced Merced CA USA"},{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison W","family":"Hsia","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-6458","authenticated-orcid":false,"given":"Blaine A","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California Davis Health Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-5561","authenticated-orcid":false,"given":"Gabriela G","family":"Loots","sequence":"additional","affiliation":[{"name":"School of Natural Sciences University of California Merced Merced CA USA"},{"name":"Physical and Life Science Directorate Lawrence Livermore National Laboratory Livermore CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0001","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jor.23341","article-title":"Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries","volume":"35","author":"Carbone","year":"2017","journal-title":"J Orthop Res."},{"issue":"5","key":"2024031419002544500_jbmr4117-bib-0002","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/036354659402200511","article-title":"Fate of the ACL-injured patient. A prospective outcome study","volume":"22","author":"Daniel","year":"1994","journal-title":"Am J Sports Med."},{"issue":"5","key":"2024031419002544500_jbmr4117-bib-0003","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00167-008-0498-x","article-title":"Function, osteoarthritis and activity after ACL-rupture: 11\u2009years follow-up results of conservative versus reconstructive treatment","volume":"16","author":"Kessler","year":"2008","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0004","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/art.20795","article-title":"Cartilage glycosaminoglycan loss in the acute phase after an anterior cruciate ligament injury: delayed gadolinium-enhanced magnetic resonance imaging of cartilage and synovial fluid analysis","volume":"52","author":"Tiderius","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"9","key":"2024031419002544500_jbmr4117-bib-0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092657","article-title":"Comparative transcriptomics identifies novel genes and pathways involved in post-traumatic osteoarthritis development and progression","volume":"19","author":"Sebastian","year":"2018","journal-title":"Int J Mol Sci."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0006","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J Orthop Res."},{"issue":"2","key":"2024031419002544500_jbmr4117-bib-0007","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jor.22208","article-title":"Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury","volume":"31","author":"Bigoni","year":"2013","journal-title":"J Orthop Res."},{"issue":"7","key":"2024031419002544500_jbmr4117-bib-0008","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ni.2640","article-title":"Commensal bacteria at the interface of host metabolism and the immune system","volume":"14","author":"Brestoff","year":"2013","journal-title":"Nat Immunol."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0009","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbrc.2019.05.166","article-title":"Notch signaling inhibition protects against LPS mediated osteolysis","volume":"515","author":"Goel","year":"2019","journal-title":"Biochem Biophys Res Commun."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1677\/JOE-08-0568","article-title":"Bone loss in inflammatory disorders","volume":"201","author":"Hardy","year":"2009","journal-title":"J Endocrinol."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0011","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/er.2007-0038","article-title":"Osteoimmunology: interactions of the bone and immune system","volume":"29","author":"Lorenzo","year":"2008","journal-title":"Endocr Rev."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0012","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrd3669","article-title":"Inflammatory bone loss: pathogenesis and therapeutic intervention","volume":"11","author":"Redlich","year":"2012","journal-title":"Nat Rev Drug Discov."},{"issue":"7","key":"2024031419002544500_jbmr4117-bib-0013","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.2460\/ajvr.1996.57.07.1080","article-title":"Immunohistochemical analysis of an equine model of synovitis-induced arthritis","volume":"57","author":"Todhunter","year":"1996","journal-title":"Am J Vet Res."},{"issue":"2","key":"2024031419002544500_jbmr4117-bib-0014","first-page":"107","article-title":"An induced synovitis disease model in ponies","volume":"77","author":"Firth","year":"1987","journal-title":"Cornell Vet."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-3306.1994.tb04056.x","article-title":"Experimentally-induced synovitis as a model for acute synovitis in the horse","volume":"26","author":"Palmer","year":"1994","journal-title":"Equine Vet J."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0016","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2460\/ajvr.1993.54.03.379","article-title":"Effects of intra-articularly administered endotoxin on clinical signs of disease and synovial fluid tumor necrosis factor, interleukin 6, and prostaglandin E2 values in horses","volume":"54","author":"Hawkins","year":"1993","journal-title":"Am J Vet Res."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0017","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1467-2995.2009.00452.x","article-title":"Effects of intraarticular ropivacaine and morphine on lipopolysaccharide-induced synovitis in horses","volume":"36","author":"Santos","year":"2009","journal-title":"Vet Anaesth Analg."},{"issue":"8","key":"2024031419002544500_jbmr4117-bib-0018","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.joca.2018.05.016","article-title":"Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice","volume":"26","author":"Ulici","year":"2018","journal-title":"Osteoarthr Cartil."},{"key":"2024031419002544500_jbmr4117-bib-0019","first-page":"1120","volume-title":"MRL\/MpJ mouse shows reduced intra-articular and systemic inflammation following articular fracture","author":"Furman","year":"2009"},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/art.23288","article-title":"Absence of posttraumatic arthritis following intraarticular fracture in the MRL\/MpJ mouse","volume":"58","author":"Ward","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"8","key":"2024031419002544500_jbmr4117-bib-0021","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1096\/fj.201802132RR","article-title":"Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL\/MpJ mice","volume":"33","author":"Deng","year":"2019","journal-title":"FASEB J."},{"issue":"5","key":"2024031419002544500_jbmr4117-bib-0022","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1189\/jlb.3A1214-601RR","article-title":"Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model","volume":"98","author":"Kay","year":"2015","journal-title":"J Leukoc Biol."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0023","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jor.22480","article-title":"Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis","volume":"32","author":"Lockwood","year":"2014","journal-title":"J Orthop Res."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0024","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1038\/s41598-018-20643-3","article-title":"Brain region-dependent heterogeneity and dose-dependent difference in transient microglia population increase during lipopolysaccharide-induced inflammation","volume":"8","author":"Furube","year":"2018","journal-title":"Sci Rep."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0025","first-page":"R125","article-title":"Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice","volume":"266","author":"Kozak","year":"1994","journal-title":"Am J Physiol."},{"issue":"10","key":"2024031419002544500_jbmr4117-bib-0026","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.joca.2015.05.009","article-title":"Non-invasive mouse models of post-traumatic osteoarthritis","volume":"23","author":"Christiansen","year":"2015","journal-title":"Osteoarthr Cartil."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0027","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jor.23263","article-title":"Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis: global molecular changes after ACL injury","volume":"35","author":"Chang","year":"2017","journal-title":"J Orthop Res."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0028","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/jbmr.3397","article-title":"SOST\/Sclerostin improves posttraumatic osteoarthritis and inhibits MMP2\/3 expression after injury: SOST overexpression improves PTOA outcomes","volume":"33","author":"Chang","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024031419002544500_jbmr4117-bib-0029","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/bja\/53.12.1243","article-title":"Isoflurane","volume":"53","author":"Prys-Roberts","year":"1981","journal-title":"Br J Anaesth."},{"issue":"7","key":"2024031419002544500_jbmr4117-bib-0030","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"Suppl 3","key":"2024031419002544500_jbmr4117-bib-0031","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative\u2014recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr Cartil."},{"key":"2024031419002544500_jbmr4117-bib-0032","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bone.2015.04.048","article-title":"Sclerostin antibody treatment improves fracture outcomes in a type I diabetic mouse model","volume":"82","author":"Yee","year":"2016","journal-title":"Bone."},{"issue":"7","key":"2024031419002544500_jbmr4117-bib-0033","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2012.04.014","article-title":"Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis","volume":"20","author":"Christiansen","year":"2012","journal-title":"Osteoarthr Cartil."},{"issue":"2","key":"2024031419002544500_jbmr4117-bib-0034","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/odi.12592","article-title":"PKR regulates LPS-induced osteoclast formation and bone destruction in vitro and in vivo","volume":"23","author":"Teramachi","year":"2017","journal-title":"Oral Dis."},{"issue":"7","key":"2024031419002544500_jbmr4117-bib-0035","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/08820139.2013.822766","article-title":"The role of cytokines in inflammatory bone loss","volume":"42","author":"Souza","year":"2013","journal-title":"Immunol Invest."},{"issue":"13","key":"2024031419002544500_jbmr4117-bib-0036","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1084\/jem.20131044","article-title":"RNA recognition by human TLR8 can lead to autoimmune inflammation","volume":"210","author":"Guiducci","year":"2013","journal-title":"J Exp Med."},{"issue":"8","key":"2024031419002544500_jbmr4117-bib-0037","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.1302998","article-title":"Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis","volume":"193","author":"Kim","year":"2014","journal-title":"J Immunol."},{"issue":"8","key":"2024031419002544500_jbmr4117-bib-0038","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.4049\/jimmunol.179.8.5474","article-title":"The chemokine CCL6 promotes innate immunity via immune cell activation and recruitment","volume":"179","author":"Coelho","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0039","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00782-17","article-title":"CCR2+ inflammatory monocytes are recruited to Yersinia pseudotuberculosis pyogranulomas and dictate adaptive responses at the expense of innate immunity during oral infection","volume":"86","author":"Zhang","year":"2018","journal-title":"Infect Immun."},{"issue":"5\u20136","key":"2024031419002544500_jbmr4117-bib-0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/09629350400014172","article-title":"Role of CC chemokine CCL6\/C10 as a monocyte chemoattractant in a murine acute peritonitis","volume":"13","author":"LaFleur","year":"2004","journal-title":"Mediators Inflamm."},{"issue":"5","key":"2024031419002544500_jbmr4117-bib-0041","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.4049\/jimmunol.177.5.2948","article-title":"CD4+ T cell expressed CD80 regulates central nervous system effector function and survival during experimental autoimmune encephalomyelitis","volume":"177","author":"Podojil","year":"2006","journal-title":"J Immunol."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0042","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.matbio.2008.01.006","article-title":"Collagen IX-deficiency seriously compromises growth cartilage development in mice","volume":"27","author":"Dreier","year":"2008","journal-title":"Matrix Biol."},{"key":"2024031419002544500_jbmr4117-bib-0043","doi-asserted-by":"crossref","first-page":"e1469","DOI":"10.1038\/cddis.2014.444","article-title":"Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation","volume":"5","author":"Gu","year":"2014","journal-title":"Cell Death Dis."},{"key":"2024031419002544500_jbmr4117-bib-0044","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.matbio.2014.05.008","article-title":"Nanomechanical phenotype of chondroadherin-null murine articular cartilage","volume":"38","author":"Batista","year":"2014","journal-title":"Matrix Biol."},{"issue":"7542","key":"2024031419002544500_jbmr4117-bib-0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14259","article-title":"Notum deacylates Wnt proteins to suppress signalling activity","volume":"519","author":"Kakugawa","year":"2015","journal-title":"Nature."},{"issue":"5","key":"2024031419002544500_jbmr4117-bib-0046","doi-asserted-by":"crossref","first-page":"e0177829","DOI":"10.1371\/journal.pone.0177829","article-title":"Gla-rich protein function as an anti-inflammatory agent in monocytes\/macrophages: implications for calcification-related chronic inflammatory diseases","volume":"12","author":"Viegas","year":"2017","journal-title":"PloS One."},{"issue":"31","key":"2024031419002544500_jbmr4117-bib-0047","doi-asserted-by":"crossref","first-page":"27206","DOI":"10.1074\/jbc.M111.218065","article-title":"Cytokine-like 1 knock-out mice (Cytl1\u2212\/\u2212) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction","volume":"286","author":"Jeon","year":"2011","journal-title":"J Biol Chem."},{"key":"2024031419002544500_jbmr4117-bib-0048","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fcell.2019.00272","article-title":"Epigenetic programing of B-cell lymphoma by BCL6 and its genetic deregulation","volume":"7","author":"Yang","year":"2019","journal-title":"Front Cell Dev Biol."},{"key":"2024031419002544500_jbmr4117-bib-0049","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nbd.2017.06.001","article-title":"CXCL1\/CXCR2 signaling in pathological pain: role in peripheral and central sensitization","volume":"105","author":"Silva","year":"2017","journal-title":"Neurobiol Dis."},{"issue":"5161","key":"2024031419002544500_jbmr4117-bib-0050","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.8178155","article-title":"Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor","volume":"264","author":"Grabstein","year":"1994","journal-title":"Science."},{"issue":"8","key":"2024031419002544500_jbmr4117-bib-0051","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/brain\/awh193","article-title":"Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population","volume":"127","author":"Barton","year":"2004","journal-title":"Brain."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0052","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1158\/1078-0432.CCR-08-0716","article-title":"Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival","volume":"15","author":"Abraham","year":"2009","journal-title":"Clin Cancer Res."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0053","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0006-291X(03)00045-7","article-title":"Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide","volume":"301","author":"Larson","year":"2003","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0054","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.4110\/in.2018.18.e5","article-title":"Tissue-specific role of CX3CR1 expressing immune cells and their relationships with human disease","volume":"18","author":"Lee","year":"2018","journal-title":"Immune Netw."},{"issue":"2","key":"2024031419002544500_jbmr4117-bib-0055","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/cei.12880","article-title":"Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis","volume":"187","author":"Gaur","year":"2017","journal-title":"Clin Exp Immunol."},{"issue":"11","key":"2024031419002544500_jbmr4117-bib-0056","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","article-title":"Inflammation in joint injury and post-traumatic osteoarthritis","volume":"23","author":"Lieberthal","year":"2015","journal-title":"Osteoarthr Cartil."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0057","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/BOR.0000000000000449","article-title":"Inflammation in bone physiology and pathology","volume":"30","author":"Adamopoulos","year":"2018","journal-title":"Curr Opin Rheumatol."},{"issue":"7771","key":"2024031419002544500_jbmr4117-bib-0058","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally renewing resident synovial macrophages provide a protective barrier for the joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature."},{"issue":"3","key":"2024031419002544500_jbmr4117-bib-0059","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/annrheumdis-2011-201203","article-title":"Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNF\u03b1 in monocytes","volume":"72","author":"Chamberlain","year":"2013","journal-title":"Ann Rheum Dis."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0060","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4049\/jimmunol.1102977","article-title":"TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-\u03b1 levels","volume":"189","author":"Chamberlain","year":"2012","journal-title":"J Immunol."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0061","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.4049\/jimmunol.166.4.2801","article-title":"A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases","volume":"166","author":"Vallon","year":"2001","journal-title":"J Immunol."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0062","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1442-2042.1995.tb00464.x","article-title":"Plasma endotoxin concentrations in patients with urinary tract infections","volume":"2","author":"Goto","year":"1995","journal-title":"Int J Urol."},{"key":"2024031419002544500_jbmr4117-bib-0063","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13099-018-0230-4","article-title":"Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities","volume":"10","author":"Liang","year":"2018","journal-title":"Gut Pathog."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0064","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/MCB.20.4.1227-1233.2000","article-title":"The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation","volume":"20","author":"Texido","year":"2000","journal-title":"Mol Cell Biol."},{"issue":"1","key":"2024031419002544500_jbmr4117-bib-0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(00)80591-9","article-title":"BLNK: a central linker protein in B cell activation","volume":"9","author":"Fu","year":"1998","journal-title":"Immunity."},{"key":"2024031419002544500_jbmr4117-bib-0066","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.3389\/fimmu.2018.02235","article-title":"CD22: a regulator of innate and adaptive B cell responses and autoimmunity","volume":"9","author":"Clark","year":"2018","journal-title":"Front Immunol."},{"issue":"10","key":"2024031419002544500_jbmr4117-bib-0067","doi-asserted-by":"crossref","first-page":"e76115","DOI":"10.1371\/journal.pone.0076115","article-title":"Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects","volume":"8","author":"Luger","year":"2013","journal-title":"PloS One."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0068","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1309\/G689-2J36-KCTC-WD5N","article-title":"Usefulness of CD79b expression in the diagnosis of B-cell chronic lymphoproliferative disorders","volume":"113","author":"McCarron","year":"2000","journal-title":"Am J Clin Pathol."},{"issue":"6","key":"2024031419002544500_jbmr4117-bib-0069","doi-asserted-by":"crossref","first-page":"637","DOI":"10.33549\/physiolres.932307","article-title":"Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene","volume":"61","author":"Sengul","year":"2012","journal-title":"Physiol Res."},{"issue":"4","key":"2024031419002544500_jbmr4117-bib-0070","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00586-010-1598-0","article-title":"Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women","volume":"20","author":"Urano","year":"2011","journal-title":"Eur Spine J."},{"issue":"2","key":"2024031419002544500_jbmr4117-bib-0071","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1359\/jbmr.061104","article-title":"Pericellular matrilins regulate activation of chondrocytes by cyclic load-induced matrix deformation","volume":"22","author":"Kanbe","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024031419002544500_jbmr4117-bib-0072","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/jbmr.2582","article-title":"Conditional deletion of Indian hedgehog in limb mesenchyme results in complete loss of growth plate formation but allows mature osteoblast differentiation","volume":"30","author":"Amano","year":"2015","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.4117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/35\/11\/2229\/55460618\/jbmr4117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/35\/11\/2229\/55460618\/jbmr4117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T15:15:47Z","timestamp":1710429347000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/35\/11\/2229\/7516890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,21]]},"references-count":72,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6,21]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4117","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4117\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4117\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,6,21]]},"assertion":[{"value":"2019-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}